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PMID: 15220463 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen.

Journal of virology ·Vol. 78 ·No. 14 ·2004-07-00 ·Pages 7852-60

Sutkowski N, Chen G, Calderon G, Huber BT

Abstract

Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins. Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity.

MeSH Terms
Animals Cell Line Endogenous Retroviruses/genetics,metabolism Gene Expression Regulation, Viral Herpesvirus 4, Human/genetics,metabolism Humans Superantigens/genetics,metabolism Transcriptional Activation Viral Envelope Proteins/genetics,metabolism Viral Matrix Proteins/genetics,metabolism Virus Latency
Chemicals
EBV-associated membrane antigen, Epstein-Barr virus Superantigens Viral Envelope Proteins Viral Matrix Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sutkowski Natalie
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA.
Chen Gang
Calderon German
Huber Brigitte T
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.78.14.7852-7860.2004
Published
2004-07-00
Pages
7852-60
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC434102
Subset
IM
Grants
NCI NIH HHS · K01 CA095443 · United States
NIAID NIH HHS · R37 AI014910 · United States
NIAID NIH HHS · R37 AI14910 · United States
External Links
PubMed source DOI: 10.1128/JVI.78.14.7852-7860.2004 PMC Full Text View journal details
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