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PMID: 8840782 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Virus-encoded superantigens.

Microbiological reviews ·Vol. 60 ·No. 3 ·1996-09-00 ·Pages 473-82

Huber BT, Hsu PN, Sutkowski N

Abstract

Superantigens are microbial agents that have a strong effect on the immune response of the host. Their initial target is the T lymphocyte, but a whole cascade of immunological reactions ensues. It is thought that the microbe engages the immune system of the host to its own advantage, to facilitate persistent infection and/or transmission. In this review, we discuss in detail the structure and function of the superantigen encoded by the murine mammary tumor virus, a B-type retrovirus which is the causative agent of mammary carcinoma. We will also outline what has more recently become known about superantigen activity associated with two human herpesviruses, cytomegalovirus and Epstein-Barr virus. It is likely that we have only uncovered the tip of the iceberg in our discovery of microbial superantigens, and we predict a flood of new information on this topic shortly.

MeSH Terms
Animals Antigens, Viral/genetics,immunology Cytomegalovirus/genetics,immunology Herpesvirus 4, Human/genetics,immunology Humans Mammary Tumor Virus, Mouse/genetics,immunology Mice Rabies virus/genetics,immunology Superantigens/genetics,immunology
Chemicals
Antigens, Viral Superantigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Huber B T
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA. [email protected]
Hsu P N
Sutkowski N
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Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.60.3.473-482.1996
Email
[email protected]
Published
1996-09-00
Pages
473-82
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC239452
Subset
IM
Grants
NIDDK NIH HHS · 1P30DK39428 · United States
NIAMS NIH HHS · 5T32 AR07570-04 · United States
NIAID NIH HHS · R37-AI14910 · United States
External Links
PubMed source DOI: 10.1128/mr.60.3.473-482.1996 PMC Full Text
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