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PMID: 19887069 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Role of vesicle tethering factors in the ER-Golgi membrane traffic.

FEBS letters ·Vol. 583 ·No. 23 ·2009-12-03 ·Pages 3770-83

Sztul E, Lupashin V

Abstract

Tethers are a diverse group of loosely related proteins and protein complexes grouped into three families based on structural and functional similarities. A well-accepted role for tethering factors is the initial attachment of transport carriers to acceptor membranes prior to fusion. However, accumulating evidence indicates that tethers are more than static bridges. Tethers have been shown to interact with components of the fusion machinery and with components involved in vesicle formation. Tethers belonging to the three families act at the same stage of traffic, suggesting that they mediate distinct events during vesicle tethering. Thus, multiple tether-facilitated events are required to provide selectivity to vesicle fusion. In this review, we highlight findings that support this model.

MeSH Terms
Animals Biological Transport Cytoplasmic Vesicles/metabolism Endoplasmic Reticulum/metabolism Golgi Apparatus/metabolism Humans Intracellular Membranes/metabolism
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sztul Elizabeth
Department of Cell Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA.
Lupashin Vladimir
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Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
1873-3468
DOI
10.1016/j.febslet.2009.10.083
Published
2009-12-03
Epub
2009-00-01
Pages
3770-83
Language
English
Region
England
NLM ID
0155157
PMCID
PMC2788073
Subset
IM
Grants
NIGMS NIH HHS · R01 GM062696-09 · United States
NIGMS NIH HHS · R01 GM083144 · United States
FIC NIH HHS · R03 TW005916 · United States
FIC NIH HHS · R03 TW005916-01A1 · United States
External Links
PubMed source DOI: 10.1016/j.febslet.2009.10.083 PMC Full Text View journal details
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