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PMID: 2463478 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The carboxy-terminal sequence of p56lck can regulate p60c-src.

Molecular and cellular biology ·Vol. 8 ·No. 8 ·1988-08-00 ·Pages 3560-4

MacAuley A, Cooper JA

Abstract

A chimera containing the coding region for residues 1 to 516 of p60c-src and residues 495 to 509 (the carboxy terminus) of p56lck was constructed and expressed in mouse fibroblasts. The chimeric protein appeared to be phosphorylated and regulated in the same fashion as p60c-src.

MeSH Terms
Amino Acid Sequence Base Sequence Genes Genes, Viral Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Molecular Sequence Data Peptide Mapping Phosphopeptides/analysis Phosphorylation Protein-Tyrosine Kinases/genetics,metabolism Proto-Oncogene Proteins/genetics,metabolism Proto-Oncogene Proteins pp60(c-src) Regulatory Sequences, Nucleic Acid
Chemicals
Phosphopeptides Proto-Oncogene Proteins Protein-Tyrosine Kinases Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Proto-Oncogene Proteins pp60(c-src)
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
MacAuley A
Department of Cell Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Cooper J A
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43 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.8.8.3560-3564.1988
Published
1988-08-00
Pages
3560-4
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC363597
Subset
IM
Grants
NCI NIH HHS · CA-41072 · United States
External Links
PubMed source DOI: 10.1128/mcb.8.8.3560-3564.1988 PMC Full Text View journal details
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