Home LiteratureArticle Details
PMID: 3072553 Published · ppublish English Journal Article Review

The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response.

Pharmaceutical research ·Vol. 5 ·No. 3 ·1988-03-00 ·Pages 129-39

Larrick JW, Kunkel SL

Abstract

Monocytes and tissue macrophages produce at least two groups of protein mediators of inflammation, interleukin 1 (IL-1) and tumor necrosis factor (TNF). Recent studies have emphasized that TNF and IL-1 modulate the inflammatory function of endothelial cells, leukocytes, and fibroblasts. Although these cytokines share a number of biologic properties, they have quite distinct gene and protein structures. It is our purpose to focus on the role of these mediators in inflammation.

MeSH Terms
Amino Acid Sequence Animals Humans Inflammation/immunology,physiopathology Interleukin-1/physiology Molecular Sequence Data Tumor Necrosis Factor-alpha/physiology
Chemicals
Interleukin-1 Tumor Necrosis Factor-alpha
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Larrick J W
Department of Immunology, Cetus Corp, Palo Alto, California 94303.
Kunkel S L
References (142)
142 references, click to expand
  1. Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line.
    Proc Natl Acad Sci U S A. 1986 Feb;83(4):1060-4 PMID: 2937055
  2. Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.
    Proc Natl Acad Sci U S A. 1985 Nov;82(22):7626-30 PMID: 2999773
  3. A urine inhibitor of interleukin 1 activity that blocks ligand binding.
    J Immunol. 1987 Sep 1;139(5):1546-9 PMID: 2957429
  4. An improved assay for the detection of interleukin 1.
    J Immunol Methods. 1985 May 10;79(1):39-45 PMID: 3873500
  5. The human LT system. XII. Purification and functional studies of LT and "TNF-like" LT forms from a continuous human T cell line.
    J Immunol. 1986 Sep 15;137(6):1885-92 PMID: 2427583
  6. Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.
    J Exp Med. 1985 Dec 1;162(6):2163-8 PMID: 2999289
  7. Detection and characterization of high affinity plasma membrane receptors for human interleukin 1.
    J Exp Med. 1985 Aug 1;162(2):501-15 PMID: 3160805
  8. C3a(C3adesArg) induces production and release of interleukin 1 by cultured human monocytes.
    J Immunol. 1987 Aug 1;139(3):794-9 PMID: 3496391
  9. Modulation of endothelial cell hemostatic properties by tumor necrosis factor.
    J Exp Med. 1986 Mar 1;163(3):740-5 PMID: 3753996
  10. Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes.
    Science. 1972 Sep 1;177(4051):793-5 PMID: 5052733
  11. Effect of tumor necrosis factor alpha on mitogen-activated human B cells.
    J Exp Med. 1987 Sep 1;166(3):786-91 PMID: 3040886
  12. Antiviral effects of recombinant tumour necrosis factor in vitro.
    Nature. 1986 Oct 30-Nov 5;323(6091):816-9 PMID: 3022155
  13. Two distinct factors are required for induction of T-cell growth.
    Nature. 1980 Feb 14;283(5748):664-6 PMID: 6965520
  14. Purification and characterization of a unique human interleukin 1 from the tumor cell line U937.
    J Immunol. 1986 May 1;136(9):3311-6 PMID: 3485687
  15. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.
    J Clin Invest. 1987 Mar;79(3):918-25 PMID: 3102560
  16. An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.
    J Immunol. 1986 Jun 15;136(12):4548-53 PMID: 3486903
  17. Intracellular localization of human monocyte associated interleukin 1 (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin.
    J Immunol. 1986 Apr 15;136(8):2883-91 PMID: 2420874
  18. Regulation of macrophage tumor necrosis factor production by prostaglandin E2.
    Biochem Biophys Res Commun. 1986 May 29;137(1):404-10 PMID: 3459461
  19. Interleukin 1-mediated induction of kappa-light chain synthesis and surface immunoglobulin expression on pre-B cells.
    J Immunol. 1984 Jan;132(1):223-8 PMID: 6418798
  20. Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.
    Proc Natl Acad Sci U S A. 1986 Nov;83(22):8699-702 PMID: 3464978
  21. Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.
    J Exp Med. 1986 Nov 1;164(5):1791-6 PMID: 3095481
  22. Recombinant tumor necrosis factor and interleukin-1 both stimulate human synovial cell arachidonic acid release and phospholipid metabolism.
    Biochem Biophys Res Commun. 1987 Jan 15;142(1):235-41 PMID: 3028403
  23. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.
    Science. 1985 Aug 30;229(4716):869-71 PMID: 3895437
  24. Purification to homogeneity and NH2-terminal amino acid sequence of a novel interleukin 1 species derived from a human B cell line.
    J Immunol. 1986 May 1;136(9):3304-10 PMID: 3485686
  25. Uromodulin, an immunosuppressive protein derived from pregnancy urine, is an inhibitor of interleukin 1.
    Proc Natl Acad Sci U S A. 1986 Dec;83(23):9119-23 PMID: 3538018
  26. The active form of tumor necrosis factor is a trimer.
    J Biol Chem. 1987 May 25;262(15):6951-4 PMID: 3034874
  27. Human monoclonal antibodies that recognize conserved epitopes in the core-lipid A region of lipopolysaccharides.
    J Clin Invest. 1987 May;79(5):1421-30 PMID: 2437155
  28. Interleukin 1 alpha and interleukin 1 beta bind to the same receptor on T cells.
    J Immunol. 1986 Jun 15;136(12):4509-14 PMID: 2940296
  29. Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat.
    Am J Physiol. 1983 Jun;244(6):R785-93 PMID: 6574712
  30. Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.
    J Clin Invest. 1978 May;61(5):1330-6 PMID: 659595
  31. Properties of a specific interleukin 1 (IL 1) receptor on human Epstein Barr virus-transformed B lymphocytes: identity of the receptor for IL 1-alpha and IL 1-beta.
    J Immunol. 1986 Jun 15;136(12):4496-502 PMID: 3011895
  32. Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.
    Proc Natl Acad Sci U S A. 1985 Dec;82(24):8667-71 PMID: 3866246
  33. Tumor necrosis factor increases the number of epidermal growth factor receptors on human fibroblasts.
    J Biol Chem. 1987 Feb 15;262(5):1950-4 PMID: 3546282
  34. Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.
    Biochem J. 1984 Dec 1;224(2):461-6 PMID: 6097218
  35. Recombinant tumor necrosis factor causes activation of human granulocytes.
    Blood. 1987 Feb;69(2):640-4 PMID: 3801673
  36. Lymphocyte in vitro cytotoxicity: lymphotoxins of several mammalian species.
    Nature. 1968 Sep 7;219(5158):1076-7 PMID: 5673378
  37. Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor.
    Eur J Biochem. 1985 Oct 15;152(2):253-7 PMID: 3876934
  38. Release of multiple hormones by a direct action of interleukin-1 on pituitary cells.
    Science. 1987 Oct 23;238(4826):519-21 PMID: 2821620
  39. Secretory products of macrophages.
    J Clin Invest. 1987 Feb;79(2):319-26 PMID: 3543052
  40. Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism.
    J Exp Med. 1968 Dec 1;128(6):1267-79 PMID: 5693925
  41. Potentiation of the T-lymphocyte response to mitogens. I. The responding cell.
    J Exp Med. 1972 Jul 1;136(1):128-42 PMID: 5033417
  42. Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.
    J Exp Med. 1986 Jun 1;163(6):1595-600 PMID: 3086483
  43. An update on human interleukin-1: from molecular biology to clinical relevance.
    J Clin Immunol. 1985 Sep;5(5):287-97 PMID: 3902871
  44. The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.
    Proc Natl Acad Sci U S A. 1987 Jun;84(12):4273-7 PMID: 3108890
  45. Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.
    Nature. 1985 Feb 28-Mar 6;313(6005):803-6 PMID: 3883195
  46. Interleukin 1 can act as a B-cell growth and differentiation factor.
    Proc Natl Acad Sci U S A. 1985 Dec;82(23):8153-7 PMID: 3877937
  47. Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice.
    Biochem Biophys Res Commun. 1986 Apr 14;136(1):316-21 PMID: 3486657
  48. Induction of human interleukin 1 mRNA measured by collagenase- and prostaglandin E2-stimulating activity in rheumatoid synovial cells.
    Eur J Immunol. 1984 Oct;14(10):898-901 PMID: 6092094
  49. Cachectin/TNF as well as interleukin-1 induces prostacyclin synthesis in cultured vascular endothelial cells.
    Biochem Biophys Res Commun. 1986 Dec 15;141(2):482-7 PMID: 3541932
  50. Biological effects of recombinant human tumor necrosis factor and its novel muteins on tumor and normal cell lines.
    Cancer Res. 1987 Jan 1;47(1):145-9 PMID: 3791201
  51. The role of macrophages in the acute-phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogen.
    Cell Immunol. 1981 Sep 1;63(1):164-76 PMID: 6791836
  52. The effect of temperature on the activation of thymocytes by interleukins I and II.
    J Immunol. 1983 Jan;130(1):216-21 PMID: 6600177
  53. Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).
    Proc Natl Acad Sci U S A. 1981 Apr;78(4):2474-7 PMID: 6264478
  54. Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage.
    Nature. 1986 Aug 7-13;322(6079):547-9 PMID: 3736671
  55. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin.
    Nature. 1985 Aug 8-14;316(6028):552-4 PMID: 2993897
  56. Acute in vivo effects of human recombinant tumor necrosis factor.
    Lab Invest. 1987 Jun;56(6):583-90 PMID: 3599906
  57. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1.
    Science. 1987 Oct 23;238(4826):524-6 PMID: 2443979
  58. Characterization of murine monoclonal antibodies that recognize neutralizing epitopes on human C5a.
    Infect Immun. 1987 Aug;55(8):1867-72 PMID: 2440808
  59. Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.
    J Exp Med. 1986 Mar 1;163(3):632-43 PMID: 3512757
  60. Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon.
    Nature. 1985 Dec 19-1986 Jan 1;318(6047):665-7 PMID: 3001529
  61. Fever and immunoregulation: hyperthermia, interleukins 1 and 2, and T-cell proliferation.
    Yale J Biol Med. 1982 Sep-Dec;55(5-6):437-42 PMID: 6985107
  62. Tumor necrosis factor provokes superoxide anion generation from neutrophils.
    Biochem Biophys Res Commun. 1986 Jun 30;137(3):1094-100 PMID: 3015137
  63. Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity.
    J Immunol. 1986 Oct 1;137(7):2281-5 PMID: 2428865
  64. A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia.
    Science. 1985 Aug 30;229(4716):867-9 PMID: 3839597
  65. Stimulation of B cell growth and differentiation by murine recombinant interleukin 1.
    J Immunol. 1986 Dec 15;137(12 ):3748-52 PMID: 2431042
  66. Recombinant gamma interferon induces hypertriglyceridemia and inhibits post-heparin lipase activity in cancer patients.
    J Exp Med. 1986 Oct 1;164(4):1093-101 PMID: 3093625
  67. Tumor necrosis factor inhibits MYC expression in HL-60 cells at the level of mRNA transcription.
    Proc Natl Acad Sci U S A. 1987 Jan;84(2):469-73 PMID: 3099296
  68. Induction of interleukin 2 receptor (TAC) by tumor necrosis factor in YT cells.
    J Immunol. 1987 Sep 15;139(6):1935-8 PMID: 2442261
  69. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
    J Exp Med. 1986 Jun 1;163(6):1433-50 PMID: 3486936
  70. Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma.
    J Immunol. 1986 Apr 1;136(7):2445-50 PMID: 3005411
  71. Chemotactic cytokines: the role of leukocytic pyrogen and epidermal cell thymocyte-activating factor in neutrophil chemotaxis.
    J Immunol. 1984 Feb;132(2):828-32 PMID: 6361134
  72. Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells.
    J Immunol. 1985 Dec;135(6):3969-71 PMID: 2999235
  73. Further comparisons of endogenous pyrogens and leukocytic endogenous mediators.
    Infect Immun. 1983 Jul;41(1):6-10 PMID: 6862633
  74. Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock.
    Circ Res. 1980 Jun;46(6):854-9 PMID: 7189697
  75. Inhibition of interleukin 1 activity by a factor in submandibular glands of rats.
    J Immunol. 1986 Oct 1;137(7):2245-51 PMID: 3489762
  76. Accessory cell function of human B cells. I. Production of both interleukin 1-like activity and an interleukin 1 inhibitory factor by an EBV-transformed human B cell line.
    J Exp Med. 1984 Jun 1;159(6):1637-52 PMID: 6327874
  77. Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
    Lab Invest. 1987 Mar;56(3):234-48 PMID: 3029503
  78. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.
    Proc Natl Acad Sci U S A. 1986 Jun;83(12):4533-7 PMID: 3487091
  79. Murine monoclonal antibodies defining neutralizing epitopes on tumor necrosis factor.
    Hybridoma. 1987 Aug;6(4):359-70 PMID: 2442093
  80. Secretory products of macrophages and their physiological functions.
    Am J Physiol. 1984 Jan;246(1 Pt 1):C1-9 PMID: 6364825
  81. Substance P and immunoregulation.
    Fed Proc. 1987 Jan;46(1):196-9 PMID: 2433163
  82. Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1.
    J Exp Med. 1986 Jul 1;164(1):237-50 PMID: 3487613
  83. Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies.
    Proc Natl Acad Sci U S A. 1980 Dec;77(12):7152-6 PMID: 6164058
  84. Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.
    J Immunol. 1987 Jan 15;138(2):635-40 PMID: 3098851
  85. Binding of human tumor necrosis factor to high affinity receptors on HeLa and lymphoblastoid cells sensitive to growth inhibition.
    J Biol Chem. 1985 Nov 5;260(25):13395-7 PMID: 2997166
  86. Membrane-associated IL 1-like activity on rat dendritic cells.
    J Immunol. 1986 Mar 15;136(6):2164-70 PMID: 2936823
  87. A high molecular weight component of the human tumor necrosis factor receptor is associated with cytotoxicity.
    Proc Natl Acad Sci U S A. 1987 May;84(10):3293-7 PMID: 3033642
  88. T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation.
    Proc Natl Acad Sci U S A. 1981 Feb;78(2):1133-7 PMID: 6785748
  89. Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.
    J Immunol. 1987 Mar 1;138(5):1469-74 PMID: 3805724
  90. Cloning and expression of murine interleukin-1 cDNA in Escherichia coli.
    Nature. 1984 Nov 29-Dec 5;312(5993):458-62 PMID: 6209582
  91. Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase.
    Cell. 1986 Jul 18;46(2):191-9 PMID: 3013422
  92. Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.
    J Immunol. 1986 Apr 1;136(7):2441-4 PMID: 3005410
  93. Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein.
    Science. 1987 Apr 3;236(4797):83-8 PMID: 3453112
  94. An endotoxin-induced serum factor that causes necrosis of tumors.
    Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70 PMID: 1103152
  95. The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.
    Annu Rev Immunol. 1987;5:223-52 PMID: 3109455
  96. Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.
    Proc Natl Acad Sci U S A. 1986 Oct;83(19):7467-71 PMID: 3489939
  97. Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.
    J Immunol. 1986 Mar 1;136(5):1680-7 PMID: 3485132
  98. Cachectin and tumour necrosis factor as two sides of the same biological coin.
    Nature. 1986 Apr 17-23;320(6063):584-8 PMID: 3010124
  99. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.
    J Immunol. 1985 Sep;135(3):2069-73 PMID: 3926894
  100. The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities.
    J Immunol. 1985 Feb;134(2):895-903 PMID: 3871220
  101. Regulation of lipoprotein lipase synthesis and 3T3-L1 adipocyte metabolism by recombinant interleukin 1.
    Biochim Biophys Acta. 1986 Dec 19;889(3):374-81 PMID: 3491626
  102. Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.
    J Clin Invest. 1986 Jun;77(6):1857-63 PMID: 3486886
  103. In vivo immunostimulating activity of the 163-171 peptide of human IL-1 beta.
    J Immunol. 1987 Aug 1;139(3):800-4 PMID: 2955051
  104. Receptor binding and activation of polymorphonuclear neutrophils by tumor necrosis factor-alpha.
    J Leukoc Biol. 1987 Mar;41(3):196-204 PMID: 3031189
  105. Studies of an interleukin 1 inhibitor: characterization and clinical significance.
    Clin Exp Immunol. 1986 Apr;64(1):136-45 PMID: 3488147
  106. Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae.
    Proc Natl Acad Sci U S A. 1986 Feb;83(4):1055-9 PMID: 3456562
  107. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.
    Proc Natl Acad Sci U S A. 1986 Jan;83(2):446-50 PMID: 3455781
  108. Neutrophil release after injections of endotoxin or leukocytic endogenous mediator into rats.
    J Reticuloendothel Soc. 1980 Aug;28(2):191-201 PMID: 7411537
  109. Disparate effects of tumor necrosis factor-alpha/cachectin and tumor necrosis factor-beta/lymphotoxin on hematopoietic growth factor production and neutrophil adhesion molecule expression by cultured human endothelial cells.
    J Immunol. 1987 Jun 15;138(12):4298-302 PMID: 3495589
  110. Stimulatory effect of hr tumor necrosis factor on TxB2 release by polymorphonuclears and macrophages.
    Agents Actions. 1986 Dec;19(5-6):349-50 PMID: 3825754
  111. Tumor necrosis factors: gene structure and biological activities.
    Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:597-609 PMID: 3472740
  112. Interleukin 1 regulates human metallothionein gene expression.
    Mol Cell Biol. 1985 Oct;5(10):2866-9 PMID: 3879767
  113. Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta.
    J Immunol. 1985 Oct;135(4):2562-8 PMID: 3875658
  114. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):721-4 PMID: 6334807
  115. Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons.
    Nature. 1986 Oct 30-Nov 5;323(6091):819-22 PMID: 2430188
  116. Molecular cloning of the complementary DNA for human tumor necrosis factor.
    Science. 1985 Apr 12;228(4696):149-54 PMID: 3856324
  117. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors.
    Nature. 1986 Feb 6-12;319(6053):516-8 PMID: 3511389
  118. Normal human neutrophils are a source of a specific interleukin 1 inhibitor.
    J Immunol. 1986 May 15;136(10):3686-92 PMID: 3486218
  119. Induction of membrane-associated interleukin 1 by tumor necrosis factor in human fibroblasts.
    J Immunol. 1987 Apr 1;138(7):2137-42 PMID: 3494060
  120. Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor.
    J Immunol. 1987 Jul 15;139(2):464-8 PMID: 3298430
  121. Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.
    Proc Natl Acad Sci U S A. 1986 Dec;83(23):8957-61 PMID: 3538015
  122. Prostaglandins as endogenous mediators of interleukin 1 production.
    J Immunol. 1986 Jan;136(1):186-92 PMID: 3079606
  123. Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro.
    Science. 1985 Nov 22;230(4728):943-5 PMID: 3933111
  124. Interleukin 1 inhibitory activity secreted by a human myelomonocytic cell line (M20).
    Eur J Immunol. 1986 Nov;16(11):1449-52 PMID: 3490987
  125. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
    Proc Natl Acad Sci U S A. 1984 Dec;81(24):7907-11 PMID: 6083565
  126. Interleukin 1: a common endogenous mediator of inflammation and the local Shwartzman reaction.
    J Immunol. 1986 Apr 15;136(8):3025-31 PMID: 3485678
  127. Activation of human monocyte cytotoxicity by natural and recombinant immune interferon.
    J Immunol. 1983 Dec;131(6):2821-6 PMID: 6417232
  128. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein.
    Adv Immunol. 1983;34:141-212 PMID: 6356809
  129. C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma.
    J Immunol. 1987 Oct 15;139(8):2635-40 PMID: 3116090
  130. Requirements for T cell activation by OKT3 monoclonal antibody: role of modulation of T3 molecules and interleukin 1.
    J Immunol. 1985 Sep;135(3):1714-8 PMID: 3926880
  131. The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma.
    J Immunol. 1986 Jun 15;136(12):4487-95 PMID: 3086433
  132. Recombinant human interleukin 1 alpha: purification and biological characterization.
    J Immunol. 1986 Apr 1;136(7):2492-7 PMID: 3485152
  133. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor.
    Science. 1987 Oct 23;238(4826):522-4 PMID: 2821621
  134. Interleukin 2.
    Annu Rev Immunol. 1984;2:319-33 PMID: 6443342
  135. Effects of human interleukin 1 and human tumor necrosis factor on human T lymphocyte colony formation.
    J Clin Invest. 1987 Sep;80(3):772-7 PMID: 3497951
  136. Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.
    J Exp Med. 1987 Aug 1;166(2):571-6 PMID: 3110354
  137. Chemotactic properties of partially purified human epidermal cell-derived thymocyte-activating factor (ETAF) for polymorphonuclear and mononuclear cells.
    J Immunol. 1983 Aug;131(2):816-20 PMID: 6602848
  138. Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity.
    Proc Natl Acad Sci U S A. 1985 Sep;82(17):5756-60 PMID: 2994048
  139. Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin, and tumor-promoting phorbol diesters.
    J Immunol. 1986 Jan;136(2):649-54 PMID: 2416819
  140. Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1.
    J Exp Med. 1986 Jun 1;163(6):1363-75 PMID: 3011946
  141. Spontaneous production of fibroblast-activating factor(s) by synovial inflammatory cells. A potential mechanism for enhanced tissue destruction.
    J Exp Med. 1985 Jan 1;161(1):210-22 PMID: 3968518
  142. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
    J Immunol. 1986 Sep 15;137(6):1893-6 PMID: 3091693
Article Info
Journal
Pharmaceutical research
Abbr.
Pharm Res
ISSN
0724-8741
DOI
10.1023/a:1015904721223
Published
1988-03-00
Pages
129-39
Language
English
Region
United States
NLM ID
8406521
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1015904721223 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2