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PMID: 7534739 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Control of mRNA processing and decay in prokaryotes.

Genetica ·Vol. 94 ·No. 2-3 ·1994-00-00 ·Pages 157-72

Alifano P, Bruni CB, Carlomagno MS

Abstract

Post-transcriptional mechanisms operate in regulation of gene expression in bacteria, the amount of a given gene product being also dependent on the inactivation rate of its own message. Moreover, segmental differences in mRNA stability of polycistronic transcripts may be responsible for differential expression of genes clustered in operons. Given the absence of 5' to 3' exoribonucleolytic activities in prokaryotes, both endoribonucleases and 3' to 5' exoribonucleases are involved in chemical decay of mRNA. As the 3' to 5' exoribonucleolytic activities are readily blocked by stem-loop structures which are usual at the 3' ends of bacterial messages, the rate of decay is primarily determined by the rate of the first endonucleolytic cleavage within the transcripts, after which the resulting mRNA intermediates are degraded by the 3' to 5' exoribonucleases. Consequently, the stability of a given transcript is determined by the accessibility of suitable target sites to endonucleolytic activities. A considerable number of bacterial messages decay with a net 5' to 3' directionality. Two different alternative models have been proposed to explain such a finding, the first invoking the presence of functional coupling between degradation and the movement of the ribosomes along the transcripts, the second one implying the existence of a 5' to 3' processive '5' binding nuclease'. The different systems by which these two current models of mRNA decay have been tested will be presented with particular emphasis on polycistronic transcripts.

MeSH Terms
Bacteria/genetics Gene Expression Regulation, Bacterial/genetics Models, Genetic RNA Processing, Post-Transcriptional/physiology RNA, Bacterial/genetics,metabolism RNA, Messenger/genetics,metabolism
Chemicals
RNA, Bacterial RNA, Messenger
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Alifano P
Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università di Napoli Federico II, Italy.
Bruni C B
Carlomagno M S
References (154)
154 references, click to expand
  1. Identification of a positive retroregulator that stabilizes mRNAs in bacteria.
    Proc Natl Acad Sci U S A. 1986 May;83(10):3233-7 PMID: 3085085
  2. Post-transcriptional control in the polycistronic operon environment: studies of the atp operon of Escherichia coli.
    Mol Microbiol. 1990 Aug;4(8):1233-40 PMID: 2149159
  3. Measurement of the unstable RNA in exponentially growing cultures of Bacillus subtilis and Escherichia coli.
    J Mol Biol. 1968 Jan 28;31(2):237-66 PMID: 4965769
  4. Biosynthesis of transfer RNA in Escherichia coli.
    Cell. 1975 Jan;4(1):21-9 PMID: 1090377
  5. Processing of a polycistronic mRNA requires a 5' cis element and active translation.
    Mol Microbiol. 1992 Mar;6(6):787-98 PMID: 1374148
  6. Stabilization of discrete mRNA breakdown products in ams pnp rnb multiple mutants of Escherichia coli K-12.
    J Bacteriol. 1988 Oct;170(10):4625-33 PMID: 2459106
  7. Expression of gene 19 of the conjugative plasmid R1 is controlled by RNase III.
    Mol Microbiol. 1993 Aug;9(4):717-27 PMID: 7694035
  8. Posttranscriptional control of bacteriophage lambda gene expression from a site distal to the gene.
    Proc Natl Acad Sci U S A. 1982 Jan;79(2):238-42 PMID: 6281759
  9. Effects of translation on degradation of mRNA segments transcribed from the polycistronic puf operon of Rhodobacter capsulatus.
    J Bacteriol. 1991 Feb;173(4):1478-84 PMID: 1995592
  10. The Escherichia coli unc transcription terminator enhances expression of uncC, encoding the epsilon subunit of F1-ATPase, from plasmids by stabilizing the transcript.
    Mol Microbiol. 1990 Nov;4(11):1941-6 PMID: 2150540
  11. Cleavage by RNase III in the transcripts of the met Y-nus-A-infB operon of Escherichia coli releases the tRNA and initiates the decay of the downstream mRNA.
    J Mol Biol. 1989 Nov 20;210(2):293-302 PMID: 2481042
  12. Differential inhibitory effects of antibiotics on the biosynthesis of envelope proteins of Escherichia coli.
    J Mol Biol. 1973 Sep 15;79(2):373-89 PMID: 4586413
  13. The rate of decay of Rhodobacter capsulatus-specific puf mRNA segments is differentially affected by RNase E activity in Escherichia coli.
    Gene. 1992 Nov 2;121(1):95-102 PMID: 1427102
  14. Control of gene expression in bacteriophage P22 by a small antisense RNA. I. Characterization in vitro of the Psar promoter and the sar RNA transcript.
    Genes Dev. 1987 Apr;1(2):197-203 PMID: 2445626
  15. Posttranscriptional control of Klebsiella pneumoniae nif mRNA stability by the nifL product.
    J Bacteriol. 1986 Oct;168(1):173-8 PMID: 2428807
  16. Translation and mRNA decay.
    Mol Gen Genet. 1978 Apr 6;160(2):121-9 PMID: 349350
  17. The role of mRNA degradation in the regulated expression of bacterial photosynthesis genes.
    Mol Microbiol. 1993 Jul;9(1):1-7 PMID: 7692215
  18. The ompA 5' untranslated RNA segment functions in Escherichia coli as a growth-rate-regulated mRNA stabilizer whose activity is unrelated to translational efficiency.
    J Bacteriol. 1990 Aug;172(8):4472-81 PMID: 1695894
  19. Growth-rate dependent regulation of mRNA stability in Escherichia coli.
    Nature. 1984 Nov 1-7;312(5989):75-7 PMID: 6387508
  20. Transcription and messenger RNA processing upstream of bacteriophage T4 gene 32.
    Mol Gen Genet. 1989 Oct;219(1-2):39-48 PMID: 2615764
  21. Translational control of prokaryotic gene expression.
    Trends Genet. 1990 Mar;6(3):78-85 PMID: 2183416
  22. Differential gene expression from the Escherichia coli atp operon mediated by segmental differences in mRNA stability.
    Mol Microbiol. 1991 Oct;5(10):2447-58 PMID: 1838784
  23. RNase E, an RNA processing enzyme from Escherichia coli.
    J Biol Chem. 1979 Nov 10;254(21):11154-9 PMID: 387765
  24. Multiple determinants of functional mRNA stability: sequence alterations at either end of the lacZ gene affect the rate of mRNA inactivation.
    J Bacteriol. 1991 Apr;173(7):2167-72 PMID: 1706700
  25. Identification of endonucleolytic cleavage sites involved in decay of Escherichia coli trxA mRNA.
    J Bacteriol. 1993 Feb;175(4):1043-52 PMID: 7679384
  26. Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.
    J Mol Biol. 1988 Oct 5;203(3):585-606 PMID: 3062174
  27. The Ams (altered mRNA stability) protein and ribonuclease E are encoded by the same structural gene of Escherichia coli.
    Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):1-5 PMID: 1846032
  28. Phage fl mRNA processing in Escherichia coli: search for the upstream products of endonuclease cleavage, requirement for the product of the altered mRNA stability (ams) locus.
    Biochimie. 1990 Nov;72(11):803-11 PMID: 2085543
  29. Control of functional mRNA stability in bacteria: multiple mechanisms of nucleolytic and non-nucleolytic inactivation.
    Mol Microbiol. 1992 Feb;6(3):277-82 PMID: 1372674
  30. Cloning and analysis of the entire Escherichia coli ams gene. ams is identical to hmp1 and encodes a 114 kDa protein that migrates as a 180 kDa protein.
    J Mol Biol. 1992 Nov 5;228(1):30-40 PMID: 1447789
  31. Decay of messenger ribonucleic acid from the lactose operon of Escherichia coli as a function of growth temperature.
    J Mol Biol. 1973 Feb 15;74(1):21-31 PMID: 4581286
  32. A consensus motif common to all Rho-dependent prokaryotic transcription terminators.
    Cell. 1991 Feb 8;64(3):553-63 PMID: 1703923
  33. Different half-lives of messenger RNA corresponding to different segments of the tryptophan operon of Escherichia coli.
    J Mol Biol. 1972 Nov 28;71(3):687-99 PMID: 4567470
  34. Decay of individual Escherichia coli trp messenger RNA molecules is sequentially ordered.
    J Mol Biol. 1977 Mar 5;110(3):421-39 PMID: 321792
  35. Functional mRNA half lives in E. coli.
    Mol Gen Genet. 1978 Nov 9;166(3):329-36 PMID: 368581
  36. An intercistronic stem-loop structure functions as an mRNA decay terminator necessary but insufficient for puf mRNA stability.
    Cell. 1988 Feb 26;52(4):609-19 PMID: 2449287
  37. Control of RNase E-mediated RNA degradation by 5'-terminal base pairing in E. coli.
    Nature. 1992 Dec 3;360(6403):488-91 PMID: 1280335
  38. Processing of procaryotic ribonucleic acid.
    Microbiol Rev. 1981 Dec;45(4):502-41 PMID: 6173734
  39. Integration host factor binds to a unique class of complex repetitive extragenic DNA sequences in Escherichia coli.
    Mol Microbiol. 1993 Oct;10(1):113-22 PMID: 7968507
  40. Degradation of tryptophan messenger. On the degradation of messenger RNA for the tryptophan operon in Escherichia coli.
    Nature. 1969 Jul 5;223(5201):37-40 PMID: 4893260
  41. Cleavages in the 5' region of the ompA and bla mRNA control stability: studies with an E. coli mutant altering mRNA stability and a novel endoribonuclease.
    EMBO J. 1990 Sep;9(9):2731-41 PMID: 2202593
  42. Differential expression of photosynthesis genes in R. capsulata results from segmental differences in stability within the polycistronic rxcA transcript.
    Cell. 1985 Jan;40(1):171-81 PMID: 2981627
  43. Peptide accumulation during growth of peptidase deficient mutants.
    J Mol Biol. 1980 Oct 15;143(1):35-48 PMID: 7003163
  44. Synthesis and degradation of lac mRNA in E. coli depleted of 30S ribosomal subunits.
    Mol Gen Genet. 1979 Jun 7;173(2):135-44 PMID: 386032
  45. In vivo and in vitro identity of site specific cleavages in the 5' non-coding region of ompA and bla mRNA in Escherichia coli.
    EMBO J. 1988 Jul;7(7):2269-75 PMID: 3046939
  46. Polynucleotide phosphorylase can participate in decay of mRNA in Escherichia coli in the absence of ribonuclease II.
    Mol Gen Genet. 1975 Sep 8;139(4):357-62 PMID: 1102947
  47. Erythromycin-induced ribosome stall in the ermA leader: a barricade to 5'-to-3' nucleolytic cleavage of the ermA transcript.
    J Bacteriol. 1989 Dec;171(12):6680-8 PMID: 2592348
  48. Mechanism of erythromycin-induced ermC mRNA stability in Bacillus subtilis.
    J Bacteriol. 1989 Nov;171(11):5803-11 PMID: 2478520
  49. Structure and function of the intercistronic regulatory deoC-deoA element of Escherichia coli K-12.
    EMBO J. 1984 Jan;3(1):179-83 PMID: 6323164
  50. mRNA degradation by processive 3'-5' exoribonucleases in vitro and the implications for prokaryotic mRNA decay in vivo.
    J Mol Biol. 1991 Sep 5;221(1):81-95 PMID: 1920421
  51. A novel intercistronic regulatory element of prokaryotic operons.
    Nature. 1982 Aug 19;298(5876):760-2 PMID: 7110312
  52. Translation is a non-uniform process. Effect of tRNA availability on the rate of elongation of nascent polypeptide chains.
    J Mol Biol. 1984 Dec 15;180(3):549-76 PMID: 6084718
  53. A nuclease that cuts specifically in the ribosome binding site of some T4 mRNAs.
    Proc Natl Acad Sci U S A. 1988 Dec;85(23):8895-9 PMID: 3057495
  54. A conditional lethal mutation in an Escherichia coli strain with a longer chemical lifetime of messenger RNA.
    J Mol Biol. 1979 Apr 15;129(3):343-57 PMID: 110942
  55. The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.
    Proc Natl Acad Sci U S A. 1974 Apr;71(4):1342-6 PMID: 4598299
  56. Differential stability of trp messenger RNA synthesized originating at the trp promoter and pL promoter of lambda trp phage.
    J Mol Biol. 1975 Feb 25;92(2):289-304 PMID: 1142425
  57. The stability of bacteriophage T4 gene 32 mRNA: a 5' leader sequence that can stabilize mRNA transcripts.
    Cell. 1985 Dec;43(2 Pt 1):461-9 PMID: 3000608
  58. Decay rates of different mRNA in E. coli and models of decay.
    Nat New Biol. 1972 Jul 12;238(80):46-9 PMID: 18663852
  59. Nucleotide sequence from the genetic left end of bacteriophage T7 DNA to the beginning of gene 4.
    J Mol Biol. 1981 Jun 5;148(4):303-30 PMID: 7310871
  60. A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA).
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):1966-70 PMID: 6201848
  61. Structural requirements for the processing of Escherichia coli 5 S ribosomal RNA by RNase E in vitro.
    J Mol Biol. 1992 Dec 20;228(4):1078-90 PMID: 1474579
  62. Processing enzyme ribonuclease E specifically cleaves RNA I. An inhibitor of primer formation in plasmid DNA synthesis.
    J Mol Biol. 1985 Oct 20;185(4):713-20 PMID: 2414455
  63. Differential mRNA stability controls relative gene expression within the plasmid-encoded arsenical resistance operon.
    J Bacteriol. 1990 May;172(5):2367-71 PMID: 2185215
  64. OOP RNA, produced from multicopy plasmids, inhibits lambda cII gene expression through an RNase III-dependent mechanism.
    Genes Dev. 1987 Nov;1(9):1005-13 PMID: 2962901
  65. RNaselll activation of bacteriophage lambda N synthesis.
    Mol Microbiol. 1991 Dec;5(12):2953-63 PMID: 1839745
  66. The IS10 transposase mRNA is destabilized during antisense RNA control.
    EMBO J. 1990 Apr;9(4):1259-66 PMID: 1691096
  67. Initiation of mRNA decay in Bacillus subtilis.
    Mol Microbiol. 1993 Mar;7(5):705-17 PMID: 7682278
  68. The process of infection with coliphage T7. IV. Stability of RNA in bacteriophage-infected cells.
    J Mol Biol. 1970 Aug;51(3):671-8 PMID: 4099510
  69. Differential decay of a polycistronic Escherichia coli transcript is initiated by RNaseE-dependent endonucleolytic processing.
    Mol Microbiol. 1991 Jul;5(7):1791-9 PMID: 1943710
  70. Specificity of Escherichia coli endoribonuclease RNase E: in vivo and in vitro analysis of mutants in a bacteriophage T4 mRNA processing site.
    Genes Dev. 1992 Jan;6(1):149-59 PMID: 1730408
  71. A possible complex containing RNA processing enzymes.
    Biochem Biophys Res Commun. 1982 Jun 15;106(3):768-78 PMID: 6180743
  72. Stability of ribosomal protein mRNA and translational feedback regulation in Escherichia coli.
    Mol Gen Genet. 1985;199(3):543-6 PMID: 3897787
  73. Characterization of a cis-acting regulatory mutation that maps at the distal end of the Escherichia coli glyA gene.
    J Bacteriol. 1985 Feb;161(2):650-4 PMID: 3881406
  74. Gene 32 transcription and mRNA processing in T4-related bacteriophages.
    Mol Microbiol. 1991 Mar;5(3):715-25 PMID: 2046553
  75. RNase E activity is conferred by a single polypeptide: overexpression, purification, and properties of the ams/rne/hmp1 gene product.
    Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9006-10 PMID: 8415644
  76. Differential mRNA stability controls relative gene expression within a polycistronic operon.
    Cell. 1987 Dec 24;51(6):1131-43 PMID: 2446776
  77. Interference of bacteriophage T4 in the reproduction of RNA-phage M12.
    J Mol Biol. 1967 Oct 14;29(1):173-90 PMID: 4861612
  78. The functional stability of the lacZ transcript is sensitive towards sequence alterations immediately downstream of the ribosome binding site.
    Mol Gen Genet. 1987 Aug;209(1):179-87 PMID: 3312955
  79. Functional inactivation of lac alpha-peptide mRNA by a factor that purifies that Escherichia coli RNase III.
    J Biol Chem. 1981 Feb 25;256(4):1896-902 PMID: 6257691
  80. Induced mRNA stability in Bacillus subtilis.
    Proc Natl Acad Sci U S A. 1987 Jan;84(2):498-502 PMID: 3099297
  81. lac Transcription in Escherichia coli cells treated with chloramphenicol.
    J Bacteriol. 1982 Jul;151(1):251-61 PMID: 7045075
  82. An essential yeast gene with homology to the exonuclease-encoding XRN1/KEM1 gene also encodes a protein with exoribonuclease activity.
    Mol Cell Biol. 1993 Jan;13(1):341-50 PMID: 8417335
  83. Analysis of mRNA decay and rRNA processing in Escherichia coli multiple mutants carrying a deletion in RNase III.
    J Bacteriol. 1993 Jan;175(1):229-39 PMID: 8416898
  84. The rate of processing and degradation of antisense RNAI regulates the replication of ColE1-type plasmids in vivo.
    Cell. 1991 Jun 28;65(7):1233-42 PMID: 1712252
  85. Cloned DNA sequences that determine mRNA stability of bacteriophage phi X174 in vivo are functional.
    Nucleic Acids Res. 1985 Aug 26;13(16):5937-48 PMID: 2994019
  86. RNA processing by RNase III is involved in the synthesis of Escherichia coli polynucleotide phosphorylase.
    Mol Gen Genet. 1987 Aug;209(1):28-32 PMID: 2823071
  87. Repetitive extragenic palindromic sequences, mRNA stability and gene expression: evolution by gene conversion? A review.
    Gene. 1988 Dec 10;72(1-2):3-14 PMID: 3072249
  88. Regulatory regions of two transport operons under nitrogen control: nucleotide sequences.
    Proc Natl Acad Sci U S A. 1982 Feb;79(4):1083-7 PMID: 7041112
  89. Evidence that the 5' end of lac mRNA starts to decay as soon as it is synthesized.
    J Bacteriol. 1985 Feb;161(2):820-2 PMID: 3918023
  90. RNase E, an endoribonuclease, has a general role in the chemical decay of Escherichia coli mRNA: evidence that rne and ams are the same genetic locus.
    Mol Microbiol. 1990 Dec;4(12):2127-35 PMID: 1708438
  91. Incorporation of water oxygens into intracellular nucleotides and RNA. I. Predominantly non-hydrolytic RNA turnover in Bacillus subtilis.
    J Mol Biol. 1972 Mar 14;64(3):565-79 PMID: 4336697
  92. Chromosomal location of a gene for chemical longevity of messenger ribonculeic acid in a temperature-sensitive mutant of Escherichia coli.
    J Bacteriol. 1980 Apr;142(1):325-6 PMID: 6154687
  93. Inactivation of the ribonucleic acid-processing enzyme ribonuclease E blocks cell division.
    J Bacteriol. 1981 Apr;146(1):128-32 PMID: 6163761
  94. Functional interaction of heat shock protein GroEL with an RNase E-like activity in Escherichia coli.
    Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):277-81 PMID: 8093559
  95. The operon that encodes the sigma subunit of RNA polymerase also encodes ribosomal protein S21 and DNA primase in E. coli K12.
    Cell. 1983 Feb;32(2):335-49 PMID: 6186393
  96. Alternative patterns of his operon transcription and mRNA processing generated by metabolic perturbation.
    Gene. 1994 Aug 19;146(1):15-21 PMID: 8063100
  97. 5'-Terminal structure and mRNA stability.
    Nature. 1977 Mar 17;266(5599):235-9 PMID: 557727
  98. Effect of premature termination of translation on mRNA stability depends on the site of ribosome release.
    Proc Natl Acad Sci U S A. 1987 Jul;84(14):4890-4 PMID: 2440033
  99. Repetitive extragenic palindromic sequences: a major component of the bacterial genome.
    Cell. 1984 Jul;37(3):1015-26 PMID: 6378385
  100. Maturation of Escherichia coli tryptophan operon mRNA: evidence for 3' exonucleolytic processing after rho-dependent termination.
    EMBO J. 1985 Jul;4(7):1887-91 PMID: 2992951
  101. Autoregulation of RNase III operon by mRNA processing.
    EMBO J. 1989 Nov;8(11):3401-7 PMID: 2583104
  102. Transcription of single-copy hybrid lacZ genes by T7 RNA polymerase in Escherichia coli: mRNA synthesis and degradation can be uncoupled from translation.
    Nucleic Acids Res. 1990 Oct 11;18(19):5787-92 PMID: 2216770
  103. IS10 mRNA stability and steady state levels in Escherichia coli: indirect effects of translation and role of rne function.
    Mol Microbiol. 1993 Jul;9(2):233-47 PMID: 7692216
  104. Escherichia coli cell division inhibitor DicF-RNA of the dicB operon. Evidence for its generation in vivo by transcription termination and by RNase III and RNase E-dependent processing.
    J Mol Biol. 1990 Apr 5;212(3):461-71 PMID: 1691299
  105. T7 early RNAs and Escherichia coli ribosomal RNAs are cut from large precursor RNAs in vivo by ribonuclease 3.
    Proc Natl Acad Sci U S A. 1973 Dec;70(12):3296-3300 PMID: 4587248
  106. Nucleotide sequence of the rpsU-dnaG-rpoD operon from Salmonella typhimurium and a comparison of this sequence with the homologous operon of Escherichia coli.
    Gene. 1985;40(1):67-78 PMID: 3005129
  107. RNase III cleavages in non-coding leaders of Escherichia coli transcripts control mRNA stability and genetic expression.
    Biochimie. 1990 Nov;72(11):825-34 PMID: 2085545
  108. Processed mRNA with differential stability in the regulation of E. coli pilin gene expression.
    Cell. 1988 Jan 29;52(2):197-206 PMID: 2449283
  109. Genetic studies of cleavage-initiated mRNA decay and processing of ribosomal 9S RNA show that the Escherichia coli ams and rne loci are the same.
    Mol Microbiol. 1991 Apr;5(4):857-64 PMID: 1713283
  110. Stabilization of translationally active mRNA by prokaryotic REP sequences.
    Cell. 1987 Jan 30;48(2):297-310 PMID: 2433046
  111. Copurification of E. coli RNAase E and PNPase: evidence for a specific association between two enzymes important in RNA processing and degradation.
    Cell. 1994 Mar 11;76(5):889-900 PMID: 7510217
  112. Isolation and properties of a single-strand 5'----3' exoribonuclease from Ehrlich ascites tumor cell nucleoli.
    Biochemistry. 1984 Sep 11;23(19):4367-73 PMID: 6207856
  113. The stability of E. coli gene transcripts is dependent on determinants localized to specific mRNA segments.
    Cell. 1986 Jul 18;46(2):245-51 PMID: 3521892
  114. A family of dispersed repetitive extragenic palindromic DNA sequences in E. coli.
    EMBO J. 1984 Jun;3(6):1417-21 PMID: 6378622
  115. Metabolism of messenger RNA from the gal operon of Escherichia coli.
    J Mol Biol. 1974 Dec 15;90(3):581-99 PMID: 4615171
  116. Attenuation and processing of RNA from the rplJL--rpoBC transcription unit of Escherichia coli.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3331-5 PMID: 6158044
  117. The nucleotide sequence of the nitrogen regulation gene ntrB and the glnA-ntrBC intergenic region of Klebsiella pneumoniae.
    Nucleic Acids Res. 1985 Nov 11;13(21):7591-606 PMID: 2999699
  118. Escherichia coli ribosomes translate in vivo with variable rate.
    EMBO J. 1984 Dec 1;3(12):2895-8 PMID: 6396082
  119. Escherichia coli endoribonuclease RNase E: autoregulation of expression and site-specific cleavage of mRNA.
    Mol Microbiol. 1993 Aug;9(3):557-68 PMID: 8412702
  120. Processing of unstable bacteriophage T4 gene 32 mRNAs into a stable species requires Escherichia coli ribonuclease E.
    EMBO J. 1988 Nov;7(11):3601-7 PMID: 3061803
  121. Specific endonucleolytic cleavage of the mRNA for ribosomal protein S20 of Escherichia coli requires the product of the ams gene in vivo and in vitro.
    J Bacteriol. 1991 Apr;173(8):2488-97 PMID: 2013571
  122. Nucleotide sequence and biochemical characterization of the metJ gene from Salmonella typhimurium LT2.
    Nucleic Acids Res. 1985 Feb 11;13(3):673-85 PMID: 2987805
  123. Location of the RNA-processing enzymes RNase III, RNase E and RNase P in the Escherichia coli cell.
    Mol Microbiol. 1991 Jul;5(7):1801-10 PMID: 1943711
  124. Changes in the half-life of ribosomal protein messenger RNA caused by translational repression.
    J Mol Biol. 1986 Apr 5;188(3):383-92 PMID: 2426454
  125. Polarity and the degradation of mRNA.
    Nature. 1969 Oct 25;224(5217):329-31 PMID: 4898925
  126. A 5'----3' exoribonuclease of Saccharomyces cerevisiae: size and novel substrate specificity.
    Arch Biochem Biophys. 1987 Feb 1;252(2):339-47 PMID: 3545079
  127. E. coli RNases: making sense of alphabet soup.
    Cell. 1985 Apr;40(4):731-2 PMID: 2580634
  128. Removal of a terminator structure by RNA processing regulates int gene expression.
    J Mol Biol. 1984 Jun 15;176(1):39-53 PMID: 6234400
  129. Coupling of rates of transcription, translation, and messenger ribonucleic acid degradation in streptomycin-dependent mutants of Escherichia coli.
    J Bacteriol. 1976 Jan;125(1):84-93 PMID: 1107319
  130. Processing of mRNA by ribonuclease III regulates expression of gene 1.2 of bacteriophage T7.
    Cell. 1981 Dec;27(3 Pt 2):533-42 PMID: 6101205
  131. Mechanisms of mRNA decay in bacteria: a perspective.
    Gene. 1988 Dec 10;72(1-2):15-23 PMID: 3072246
  132. Site-specific endonucleolytic cleavages and the regulation of stability of E. coli ompA mRNA.
    Cell. 1988 Mar 25;52(6):893-901 PMID: 3280138
  133. The gene specifying RNase E (rne) and a gene affecting mRNA stability (ams) are the same gene.
    Mol Microbiol. 1991 Apr;5(4):851-5 PMID: 1713282
  134. Secondary structure of the mRNA for ribosomal protein S20. Implications for cleavage by ribonuclease E.
    J Biol Chem. 1992 Jan 15;267(2):1054-61 PMID: 1370457
  135. Specific endonucleolytic cleavage sites for decay of Escherichia coli mRNA.
    J Mol Biol. 1986 Nov 20;192(2):257-74 PMID: 2435917
  136. Replication of the small coliphage M13: evidence for long-living M13 specific messenger RNA.
    Nature. 1970 Jul 4;227(5253):59-60 PMID: 5422625
  137. Biological consequences of segmental alterations in mRNA stability: effects of deletion of the intercistronic hairpin loop region of the Rhodobacter capsulatus puf operon.
    EMBO J. 1987 Nov;6(11):3515-20 PMID: 3428264
  138. Decay of mRNA encoding ribosomal protein S15 of Escherichia coli is initiated by an RNase E-dependent endonucleolytic cleavage that removes the 3' stabilizing stem and loop structure.
    J Mol Biol. 1991 Jan 20;217(2):283-92 PMID: 1704067
  139. The first step in the functional inactivation of the Escherichia coli polynucleotide phosphorylase messenger is a ribonuclease III processing at the 5' end.
    EMBO J. 1987 Jul;6(7):2165-70 PMID: 3308454
  140. Unaltered stability of newly synthesized RNA in strains of Escherichia coli missing a ribonuclease specific for double-stranded RNA.
    Mol Gen Genet. 1975;136(4):317-26 PMID: 16094999
  141. Promiscuous exoribonucleases of Escherichia coli.
    J Bacteriol. 1993 Aug;175(15):4577-83 PMID: 8335617
  142. Polynucleotide phosphorylase and ribonuclease II are required for cell viability and mRNA turnover in Escherichia coli K-12.
    Proc Natl Acad Sci U S A. 1986 Jan;83(1):120-4 PMID: 2417233
  143. A 5'-terminal stem-loop structure can stabilize mRNA in Escherichia coli.
    Genes Dev. 1992 Jan;6(1):135-48 PMID: 1370426
  144. Initiation, attenuation and RNase III processing of transcripts from the Escherichia coli operon encoding ribosomal protein S15 and polynucleotide phosphorylase.
    J Mol Biol. 1986 Jan 5;187(1):23-32 PMID: 3007765
  145. Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.
    J Mol Biol. 1988 Sep 5;203(1):119-29 PMID: 2460630
  146. Structure and autoregulation of the metJ regulatory gene in Escherichia coli.
    J Biol Chem. 1984 Nov 25;259(22):14282-5 PMID: 6094549
  147. Very stable prokaryotic messenger RNA in chromosomeless Escherichia coli minicells.
    Proc Natl Acad Sci U S A. 1975 Aug;72(8):2900-4 PMID: 1103125
  148. Identification and regulation of the glnL operator-promoter of the complex glnALG operon of Escherichia coli.
    J Bacteriol. 1984 Oct;160(1):379-84 PMID: 6148334
  149. Repetitive extragenic palindromic (REP) sequences in the Escherichia coli gdhA gene.
    Gene. 1985;37(1-3):53-62 PMID: 3902576
  150. Evidence for endonucleolytic attack in decay of lac messenger RNA in Escherichia coli.
    J Mol Biol. 1974 Feb 25;83(2):143-61 PMID: 4595422
  151. Escherichia coli ribonuclease III cleavage sites.
    Cell. 1982 Oct;30(3):669-72 PMID: 6754088
  152. Metabolism of T4 messenger RNA, host messenger RNA and ribosomal RNA in T4-infected Escherichia coli B.
    J Mol Biol. 1972 Nov 28;71(3):701-15 PMID: 4567471
  153. Characterization of cat messenger RNA decay suggests that turnover occurs by endonucleolytic cleavage in a 3' to 5' direction.
    Mol Microbiol. 1992 May;6(9):1095-104 PMID: 1316985
  154. Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis.
    Proc Natl Acad Sci U S A. 1977 Jul;74(7):2734-8 PMID: 197518
Article Info
Journal
Genetica
Abbr.
Genetica
ISSN
0016-6707
DOI
10.1007/BF01443430
Published
1994-00-00
Pages
157-72
Language
English
Region
Netherlands
NLM ID
0370740
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01443430 View journal details
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