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PMID: 8988243 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Actin-, myosin- and ubiquitin-dependent endocytosis.

Experientia ·Vol. 52 ·No. 12 ·1996-12-15 ·Pages 1033-41

Riezman H, Munn A, Geli MI, Hicke L

Abstract

Endocytosis is a general term that is used to describe the internalization of external and plasma membrane molecules into the cell interior. In fact, several different mechanisms exist for the internalization step of this process. In this review we emphasize the work on the actin-dependent pathways, in particular in the yeast Saccharomyces cerevisiae, because several components of the molecular machinery are identified. In this yeast, the analysis of endocytosis in various mutants reveals a requirement for actin, calmodulin, a type I myosin, as well as a number of other proteins that affect actin dynamics. Some of these proteins have homology to proteins in animal cells that are believed to be involved in endocytosis. In addition, the demonstration that ubiquitination of some cell surface molecules is required for their efficient internalization is described. We compare the actin, myosin and ubiquitin requirements for endocytosis with recent results found studying these processes using Dictyostelium discoideum and animal cells.

MeSH Terms
Actins/pharmacology Animals Cell Membrane/metabolism Dictyostelium/metabolism Endocytosis/physiology Membrane Proteins/metabolism Myosins/pharmacology Saccharomyces cerevisiae/metabolism Ubiquitins/pharmacology
Chemicals
Actins Membrane Proteins Ubiquitins Myosins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Riezman H
Biozentrum, University of Basel, Switzerland. [email protected]
Munn A
Geli M I
Hicke L
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01952099
Email
[email protected]
Published
1996-12-15
Pages
1033-41
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01952099
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