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PMID: 9529893 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Vacuole biogenesis in Saccharomyces cerevisiae: protein transport pathways to the yeast vacuole.

Microbiology and molecular biology reviews : MMBR ·Vol. 62 ·No. 1 ·1998-03-00 ·Pages 230-47

Bryant NJ, Stevens TH

Abstract

Delivery of proteins to the vacuole of the yeast Saccharomyces cerevisiae provides an excellent model system in which to study vacuole and lysosome biogenesis and membrane traffic. This organelle receives proteins from a number of different routes, including proteins sorted away from the secretory pathway at the Golgi apparatus and endocytic traffic arising from the plasma membrane. Genetic analysis has revealed at least 60 genes involved in vacuolar protein sorting, numerous components of a novel cytoplasm-to-vacuole transport pathway, and a large number of proteins required for autophagy. Cell biological and biochemical studies have provided important molecular insights into the various protein delivery pathways to the yeast vacuole. This review describes the various pathways to the vacuole and illustrates how they are related to one another in the vacuolar network of S. cerevisiae.

MeSH Terms
Biological Transport Endocytosis Saccharomyces cerevisiae/metabolism Vacuoles/metabolism
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bryant N J
Institute of Molecular Biology, University of Oregon, Eugene 97403-1229, USA.
Stevens T H
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.62.1.230-247.1998
Published
1998-03-00
Pages
230-47
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC98912
Subset
IM
Grants
NIGMS NIH HHS · R01 GM032448 · United States
NIGMS NIH HHS · R01 GM038006 · United States
NIGMS NIH HHS · R37 GM032448 · United States
PHS HHS · M38006 · United States
NIGMS NIH HHS · GM32448 · United States
External Links
PubMed source DOI: 10.1128/MMBR.62.1.230-247.1998 PMC Full Text View journal details
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