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PMID: 9880479 Published · ppublish English Journal Article Review

Antiseptics and disinfectants: activity, action, and resistance.

Clinical microbiology reviews ·Vol. 12 ·No. 1 ·1999-01-00 ·Pages 147-79

McDonnell G, Russell AD

Abstract

Antiseptics and disinfectants are extensively used in hospitals and other health care settings for a variety of topical and hard-surface applications. A wide variety of active chemical agents (biocides) are found in these products, many of which have been used for hundreds of years, including alcohols, phenols, iodine, and chlorine. Most of these active agents demonstrate broad-spectrum antimicrobial activity; however, little is known about the mode of action of these agents in comparison to antibiotics. This review considers what is known about the mode of action and spectrum of activity of antiseptics and disinfectants. The widespread use of these products has prompted some speculation on the development of microbial resistance, in particular whether antibiotic resistance is induced by antiseptics or disinfectants. Known mechanisms of microbial resistance (both intrinsic and acquired) to biocides are reviewed, with emphasis on the clinical implications of these reports.

MeSH Terms
Anti-Infective Agents, Local/chemistry,pharmacology Disinfectants/chemistry,pharmacology Drug Resistance, Microbial Structure-Activity Relationship
Chemicals
Anti-Infective Agents, Local Disinfectants
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McDonnell G
STERIS Corporation, St. Louis Operations, St. Louis, Missouri 63166, USA. [email protected]
Russell A D
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.12.1.147
Email
[email protected]
Published
1999-01-00
Pages
147-79
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC88911
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/CMR.12.1.147 PMC Full Text View journal details
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