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PMID: 16190978 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Wrapping things up about virus RNA replication.

Traffic (Copenhagen, Denmark) ·Vol. 6 ·No. 11 ·2005-11-00 ·Pages 967-77

Mackenzie J

Abstract

All single-stranded 'positive-sense' RNA viruses that infect mammalian, insect or plant cells rearrange internal cellular membranes to provide an environment facilitating virus replication. A striking feature of these unique membrane structures is the induction of 70-100 nm vesicles (either free within the cytoplasm, associated with other induced vesicles or bound within a surrounding membrane) harbouring the viral replication complex (RC). Although similar in appearance, the cellular composition of these vesicles appears to vary for different viruses, implying different organelle origins for the intracellular sites of viral RNA replication. Genetic analysis has revealed that induction of these membrane structures can be attributed to a particular viral gene product, usually a non-structural protein. This review will highlight our current knowledge of the formation and composition of virus RCs and describe some of the similarities and differences in RNA-membrane interactions observed between the virus families Flaviviridae and Picornaviridae.

MeSH Terms
Animals Cell Membrane/genetics Genome, Viral Humans RNA Viruses/classification,genetics,physiology RNA, Viral/biosynthesis,metabolism Virus Replication
Chemicals
RNA, Viral
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mackenzie Jason
School of Molecular and Microbial Sciences, University of Queensland, St. Lucia, Queensland 4072, Australia. [email protected]
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Article Info
Journal
Traffic (Copenhagen, Denmark)
Abbr.
Traffic
ISSN
1398-9219
DOI
10.1111/j.1600-0854.2005.00339.x
Email
[email protected]
Published
2005-11-00
Pages
967-77
Language
English
Region
England
NLM ID
100939340
PMCID
PMC7169867
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1600-0854.2005.00339.x PMC Full Text View journal details
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