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PMID: 23264495 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies.

Molecular human reproduction ·Vol. 19 ·No. 4 ·2013-04-00 ·Pages 189-204

Feuer SK, Camarano L, Rinaudo PF

Abstract

Since the birth of the first IVF-conceived child in 1978, the use of assisted reproductive technologies (ART) has grown dramatically, contributing to the successful birth of 5 million individuals worldwide. However, there are several reported associations of ART with pregnancy complications, such as low birthweight (LBW), preterm birth, birth defects, epigenetic disorders, cancer and poor metabolic health. Whether this is attributed to ART procedures or to the subset of the population seeking ART remains a controversy, but the most relevant question today concerns the potential long-term implications of assisted conception. Recent evidence has emerged suggesting that ART-conceived children have distinct metabolic profiles that may predispose to cardiovascular pathologies in adulthood. Because the eldest IVF individuals are still too young to exhibit components of chronic middle-aged syndromes, the use of animal models has become particularly useful in describing the effects of unusual or stressful preimplantation experiences on adult fitness. Elucidating the molecular mechanisms by which embryos integrate environmental signals into development and metabolic gene expression programs will be essential for optimizing ART procedures such as in vitro culture conditions, embryo selection and transfer. In the future, additional animal studies to identify mechanisms underlying unfavorable ART outcomes, as well as more epidemiological reviews to monitor the long-term health of ART children are required, given that ART procedures have become routine medical practice.

MeSH Terms
Animals Congenital Abnormalities/epidemiology Embryo Culture Techniques Embryonic Development Epigenesis, Genetic Female Follow-Up Studies Mice Models, Animal Pregnancy Pregnancy Complications/epidemiology Pregnancy Outcome/epidemiology Rats Reproductive Techniques, Assisted/adverse effects Risk Assessment
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Feuer S K
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94115, USA.
Camarano L
Rinaudo P F
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Article Info
Journal
Molecular human reproduction
Abbr.
Mol Hum Reprod
ISSN
1460-2407
DOI
10.1093/molehr/gas066
Published
2013-04-00
Epub
2012-00-20
Pages
189-204
Language
English
Region
England
NLM ID
9513710
PMCID
PMC3598410
Subset
IM
Grants
NICHD NIH HHS · R01 HD062803 · United States
NICHD NIH HHS · R01:HD 062803-01A1 · United States
NIDDK NIH HHS · 5T32DK007418-32 · United States
External Links
PubMed source DOI: 10.1093/molehr/gas066 PMC Full Text View journal details
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