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PMID: 27151975 Published · ppublish English Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.

Genes & development ·Vol. 30 ·No. 9 ·2016-00-01 ·Pages 1002-19

Gascard P, Tlsty TD

Abstract

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but as an important modulator and even a driver of tumorigenicity. Within the tumor stromal milieu, heterogeneous populations of fibroblast-like cells, collectively termed carcinoma-associated fibroblasts (CAFs), are key players in the multicellular, stromal-dependent alterations that contribute to malignant initiation and progression. This review focuses on novel insights into the contributions of CAFs to disease progression, emergent events leading to the generation of CAFs, identification of CAF-specific biomarkers predictive of disease outcome, and recent therapeutic approaches aimed at blunting or reverting detrimental protumorigenic phenotypes associated with CAFs.

Keywords
CAF CAF targeted therapies carcinoma-associated fibroblasts field cancerization microenvironment stromal–epithelial interactions
MeSH Terms
Animals Carcinoma/pathology,physiopathology,therapy Disease Progression Fibroblasts/pathology Humans
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gascard Philippe
Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA;
Tlsty Thea D
Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
1549-5477
DOI
10.1101/gad.279737.116
Published
2016-00-01
Pages
1002-19
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC4863733
Subset
IM
Grants
NCI NIH HHS · R01 CA187800 · United States
NCI NIH HHS · U54 CA143803 · United States
NCI NIH HHS · P01 CA107584 · United States
NCI NIH HHS · R01 CA197977 · United States
NCI NIH HHS · R01 CA097214 · United States
NCI NIH HHS · R35 CA197694 · United States
External Links
PubMed source DOI: 10.1101/gad.279737.116 PMC Full Text View journal details
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