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PMID: 28034796 Published · ppublish English Journal Article Review

Mechanics and regulation of cytokinesis in budding yeast.

Seminars in cell & developmental biology ·Vol. 66 ·2017-00-00 ·Pages 107-118

Bhavsar-Jog YP, Bi E

Abstract

Cytokinesis is essential for the survival of all organisms. It requires concerted functions of cell signaling, force production, exocytosis, and extracellular matrix remodeling. Due to the conservation in core components and mechanisms between fungal and animal cells, the budding yeast Saccharomyces cerevisiae has served as an attractive model for studying this fundamental process. In this review, we discuss the mechanics and regulation of distinct events of cytokinesis in budding yeast, including the assembly, constriction, and disassembly of the actomyosin ring, septum formation, abscission, and their spatiotemporal coordination. We also highlight the key concepts and questions that are common to animal and fungal cytokinesis.

Keywords
Actin Actomyosin ring Cell separation Chitin ELC Exocytosis Formin IQGAP Mitotic exit Myosin RLC Saccharomyces cerevisiae Septin Septum formation
MeSH Terms
Animals Cytokinesis/genetics Saccharomyces cerevisiae/growth & development Saccharomycetales/growth & development
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bhavsar-Jog Yogini P
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bi Erfei
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: [email protected].
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Article Info
Journal
Seminars in cell & developmental biology
Abbr.
Semin Cell Dev Biol
ISSN
1096-3634
DOI
10.1016/j.semcdb.2016.12.010
Email
[email protected]
Published
2017-00-00
Epub
2016-00-27
Pages
107-118
Language
English
Region
England
NLM ID
9607332
PMCID
PMC5474357
Subset
IM
Grants
NIGMS NIH HHS · R01 GM115420 · United States
External Links
PubMed source DOI: 10.1016/j.semcdb.2016.12.010 PMC Full Text View journal details
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