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PMID: 23212898 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Mitotic exit and separation of mother and daughter cells.

Genetics ·Vol. 192 ·No. 4 ·2012-12-00 ·Pages 1165-202

Weiss EL

Abstract

Productive cell proliferation involves efficient and accurate splitting of the dividing cell into two separate entities. This orderly process reflects coordination of diverse cytological events by regulatory systems that drive the cell from mitosis into G1. In the budding yeast Saccharomyces cerevisiae, separation of mother and daughter cells involves coordinated actomyosin ring contraction and septum synthesis, followed by septum destruction. These events occur in precise and rapid sequence once chromosomes are segregated and are linked with spindle organization and mitotic progress by intricate cell cycle control machinery. Additionally, critical paarts of the mother/daughter separation process are asymmetric, reflecting a form of fate specification that occurs in every cell division. This chapter describes central events of budding yeast cell separation, as well as the control pathways that integrate them and link them with the cell cycle.

MeSH Terms
Actomyosin/genetics,metabolism Cell Cycle Proteins/genetics,metabolism Chitinases/genetics,metabolism DNA-Binding Proteins/genetics,metabolism Glucan Endo-1,3-beta-D-Glucosidase/genetics,metabolism Membrane Glycoproteins/genetics,metabolism Mitosis Nuclear Proteins/genetics,metabolism Protein Tyrosine Phosphatases/genetics,metabolism Saccharomyces cerevisiae/cytology,genetics Saccharomyces cerevisiae Proteins/genetics,metabolism Spindle Apparatus/metabolism Transcription Factors/genetics,metabolism rho GTP-Binding Proteins/genetics,metabolism
Chemicals
ACE2 protein, S cerevisiae CDC14 protein, S cerevisiae Cell Cycle Proteins DNA-Binding Proteins GAS1 protein, S cerevisiae Membrane Glycoproteins Net1 protein, S cerevisiae Nuclear Proteins Saccharomyces cerevisiae Proteins Transcription Factors Actomyosin Protein Tyrosine Phosphatases CTS1 protein, S cerevisiae Chitinases DSE4 protein, S cerevisiae Glucan Endo-1,3-beta-D-Glucosidase RHO1 protein, S cerevisiae rho GTP-Binding Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Weiss Eric L
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60201, USA.
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
1943-2631
DOI
10.1534/genetics.112.145516
Published
2012-12-00
Pages
1165-202
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC3512134
Subset
IM
Grants
NIGMS NIH HHS · R01 GM084223 · United States
NIGMS NIH HHS · GM084223 · United States
External Links
PubMed source DOI: 10.1534/genetics.112.145516 PMC Full Text View journal details
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