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PMID: 20465793 Published · epublish English Journal Article

An overview of Cdk1-controlled targets and processes.

Cell division ·Vol. 5 ·2010-05-13 ·Pages 11

Enserink JM, Kolodner RD

Abstract

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the model organism S. cerevisiae. Research performed during the past decade has significantly improved our understanding of the molecular machinery of the cell cycle. Approximately 75 targets of Cdk1 have been identified that control critical cell cycle events, such as DNA replication and segregation, transcriptional programs and cell morphogenesis. In this review we discuss currently known targets of Cdk1 in the budding yeast S. cerevisiae and highlight the role of Cdk1 in several crucial processes including maintenance of genome stability.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Enserink Jorrit M
Department of Molecular Biology, Institute of Medical Microbiology and Centre of Molecular Biology and Neuroscience, Oslo University Hospital, Sognsvannsveien 20, N-0027 Oslo, Norway. [email protected].
Kolodner Richard D
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Article Info
Journal
Cell division
Abbr.
Cell Div
ISSN
1747-1028
DOI
10.1186/1747-1028-5-11
Email
[email protected]
Published
2010-05-13
Epub
2010-00-13
Pages
11
Language
English
Region
England
NLM ID
101251560
PMCID
PMC2876151
Grants
NIGMS NIH HHS · R01 GM026017 · United States
External Links
PubMed source DOI: 10.1186/1747-1028-5-11 PMC Full Text View journal details
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