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PMID: 7565409 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Protein trafficking in kinetoplastid protozoa.

Microbiological reviews ·Vol. 59 ·No. 3 ·1995-09-00 ·Pages 325-44

Clayton C, Häusler T, Blattner J

Abstract

The kinetoplastid protozoa infect hosts ranging from invertebrates to plants and mammals, causing diseases of medical and economic importance. They are the earliest-branching organisms in eucaryotic evolution to have either mitochondria or peroxisome-like microbodies. Investigation of their protein trafficking enables us to identify characteristics that have been conserved throughout eucaryotic evolution and also reveals how far variations, or alternative mechanisms, are possible. Protein trafficking in kinetoplastids is in many respects similar to that in higher eucaryotes, including mammals and yeasts. Differences in signal sequence specificities exist, however, for all subcellular locations so far examined in detail--microbodies, mitochondria, and endoplasmic reticulum--with signals being more degenerate, or shorter, than those of their higher eucaryotic counterparts. Some components of the normal array of trafficking mechanisms may be missing in most (if not all) kinetoplastids: examples are clathrin-coated vesicles, recycling receptors, and mannose 6-phosphate-mediated lysosomal targeting. Other aspects and structures are unique to the kinetoplastids or are as yet unexplained. Some of these peculiarities may eventually prove to be weak points that can be used as targets for chemotherapy; others may turn out to be much more widespread than currently suspected.

MeSH Terms
Animals Biological Transport Endocytosis Kinetoplastida/growth & development,physiology,ultrastructure Leishmania/growth & development,ultrastructure Membrane Proteins/biosynthesis Microbodies/physiology,ultrastructure Mitochondria/chemistry,physiology,ultrastructure Monosaccharide Transport Proteins/physiology Protozoan Proteins/metabolism Trypanosoma/growth & development,ultrastructure
Chemicals
Membrane Proteins Monosaccharide Transport Proteins Protozoan Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Clayton C
Zentrum für Molekulare Biologie, Heidelberg, Germany.
Häusler T
Blattner J
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Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.59.3.325-344.1995
Published
1995-09-00
Pages
325-44
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC239364
Subset
IM
External Links
PubMed source DOI: 10.1128/mr.59.3.325-344.1995 PMC Full Text
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