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PMID: 8531888 Published · ppublish English Journal Article Review

Nitrogen control in bacteria.

Microbiological reviews ·Vol. 59 ·No. 4 ·1995-12-00 ·Pages 604-22

Merrick MJ, Edwards RA

Abstract

Nitrogen metabolism in prokaryotes involves the coordinated expression of a large number of enzymes concerned with both utilization of extracellular nitrogen sources and intracellular biosynthesis of nitrogen-containing compounds. The control of this expression is determined by the availability of fixed nitrogen to the cell and is effected by complex regulatory networks involving regulation at both the transcriptional and posttranslational levels. While the most detailed studies to date have been carried out with enteric bacteria, there is a considerable body of evidence to show that the nitrogen regulation (ntr) systems described in the enterics extend to many other genera. Furthermore, as the range of bacteria in which the phenomenon of nitrogen control is examined is being extended, new regulatory mechanisms are also being discovered. In this review, we have attempted to summarize recent research in prokaryotic nitrogen control; to show the ubiquity of the ntr system, at least in gram-negative organisms; and to identify those areas and groups of organisms about which there is much still to learn.

MeSH Terms
Amino Acid Sequence Bacteria/genetics Bacterial Physiological Phenomena Enterobacteriaceae/genetics,physiology Gene Expression Regulation, Bacterial Genes, Bacterial Glutamate-Ammonia Ligase/metabolism Molecular Sequence Data Nitrogen/metabolism Nitrogen Fixation/genetics
Chemicals
Glutamate-Ammonia Ligase Nitrogen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Merrick M J
Nitrogen Fixation Laboratory, John Innes Centre, Norwich, United Kingdom.
Edwards R A
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Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.59.4.604-622.1995
Published
1995-12-00
Pages
604-22
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC239390
Subset
IM
External Links
PubMed source DOI: 10.1128/mr.59.4.604-622.1995 PMC Full Text
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