Home LiteratureArticle Details
PMID: 1943999 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control.

Microbiological reviews ·Vol. 55 ·No. 3 ·1991-09-00 ·Pages 512-42

Villarreal LP

Abstract

The historic arguments for the participation of eukaryotic DNA replication in the control of gene expression are reconsidered along with more recent evidence. An earlier view in which gene commitment was achieved with stable chromatin structures which required DNA replication to reset expression potential (D. D. Brown, Cell 37:359-365, 1984) is further considered. The participation of nonspecific stable repressor of gene activity (histones and other chromatin proteins), as previously proposed, is reexamined. The possible function of positive trans-acting factors is now further developed by considering evidence from DNA virus models. It is proposed that these positive factors act to control the initiation of replicon-specific DNA synthesis in the S phase (early or late replication timing). Stable chromatin assembles during replication into potentially active (early S) or inactive (late S) states with prevailing trans-acting factors (early) or repressing factors (late) and may asymmetrically commit daughter templates. This suggests logical schemes for programming differentiation based on replicons and trans-acting initiators. This proposal requires that DNA replication precede major changes in gene commitment. Prior evidence against a role for DNA replication during terminal differentiation is reexamined along with other results from terminal differentiation of lower eukaryotes. This leads to a proposal that DNA replication may yet underlie terminal gene commitment, but that for it to do so there must exist two distinct modes of replication control. In one mode (mitotic replication) replicon initiation is tightly linked to the cell cycle, whereas the other mode (terminal replication) initiation is not cell cycle restricted, is replicon specific, and can lead to a terminally differentiated state. Aberrant control of mitotic and terminal modes of DNA replication may underlie the transformed state. Implications of a replicon basis for chromatin structure-function and the evolution of metazoan organisms are considered.

MeSH Terms
Animals Cell Differentiation/physiology Chromatin/physiology DNA Replication Gene Expression Regulation Mitosis Replicon
Chemicals
Chromatin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Villarreal L P
Department of Molecular Biology and Biochemistry, University of California, Irvine 92717.
References (385)
385 references, click to expand
  1. Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.
    EMBO J. 1990 Mar;9(3):821-31 PMID: 2311584
  2. On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3673-7 PMID: 6943571
  3. The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates.
    EMBO J. 1990 Sep;9(9):2835-42 PMID: 2167833
  4. Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice.
    EMBO J. 1990 Sep;9(9):2843-8 PMID: 2390972
  5. Nucleosome assembly in mammalian cell extracts before and after DNA replication.
    EMBO J. 1990 Sep;9(9):2911-22 PMID: 2167837
  6. Protamine-histone replacement and DNA replication in the male mouse pronucleus.
    Mol Reprod Dev. 1990 Jan;25(1):72-6 PMID: 2203386
  7. Identification of an origin of bidirectional DNA replication in mammalian chromosomes.
    Cell. 1990 Sep 7;62(5):955-65 PMID: 2393905
  8. Replicative senescence: the human fibroblast comes of age.
    Science. 1990 Sep 7;249(4973):1129-33 PMID: 2204114
  9. Studies of an 800-kilobase DNA stretch of the Drosophila X chromosome: comapping of a subclass of scaffold-attached regions with sequences able to replicate autonomously in Saccharomyces cerevisiae.
    Mol Cell Biol. 1990 Oct;10(10):5455-63 PMID: 2118999
  10. Reduced DNA polytenization of a minichromosome region undergoing position-effect variegation in Drosophila.
    Cell. 1990 Oct 5;63(1):97-107 PMID: 2208283
  11. Chromatin assembly on replicating DNA in vitro.
    Nucleic Acids Res. 1990 Oct 11;18(19):5767-74 PMID: 2216769
  12. Deregulation of DNA polymerase beta by sense and antisense RNA expression in mouse 3T3 cells alters cell growth.
    Somat Cell Mol Genet. 1990 Jul;16(4):311-20 PMID: 1699288
  13. Globin gene regulation and switching: circa 1990.
    Cell. 1990 Nov 16;63(4):665-72 PMID: 2225071
  14. Terminal differentiation of human erythroleukemia cell line K562 induced by aphidicolin.
    Exp Cell Res. 1990 Nov;191(1):45-50 PMID: 2121512
  15. Identification of the lytic origin of DNA replication in human cytomegalovirus by a novel approach utilizing ganciclovir-induced chain termination.
    J Virol. 1990 Dec;64(12):6184-95 PMID: 2173786
  16. Chromatin structure of transcriptionally competent and repressed genes.
    EMBO J. 1990 Dec;9(12):3997-4006 PMID: 2249661
  17. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.
    Genes Dev. 1990 Oct;4(10):1637-49 PMID: 2249769
  18. The role of differentiation in the suppression of malignancy.
    J Cell Sci. 1990 Sep;97 ( Pt 1):5-10 PMID: 2258391
  19. Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells.
    Cell. 1990 Dec 21;63(6):1219-27 PMID: 1979757
  20. Multicomponent origin of cytomegalovirus lytic-phase DNA replication.
    J Virol. 1991 Feb;65(2):931-7 PMID: 1846206
  21. Histone function in transcription.
    Annu Rev Cell Biol. 1990;6:643-78 PMID: 2275823
  22. Genetic analysis of mammalian cell differentiation.
    Annu Rev Cell Biol. 1990;6:69-94 PMID: 2275825
  23. New approaches to chromatin function.
    New Biol. 1990 Mar;2(3):211-8 PMID: 2279025
  24. Actively transcribed genes are associated with the nuclear matrix.
    Nature. 1983 Dec 8-14;306(5943):607-9 PMID: 6646237
  25. Control of differentiation in heterokaryons and hybrids involving differentiation-defective myoblast variants.
    J Cell Biol. 1984 Feb;98(2):436-43 PMID: 6693490
  26. Polyomavirus growth and persistence in Friend erythroleukemic cells.
    J Virol. 1984 Feb;49(2):566-71 PMID: 6319756
  27. Quantal and proliferative cell cycles: how lineages generate cell diversity and maintain fidelity.
    Prog Clin Biol Res. 1983;134:213-27 PMID: 6664999
  28. Changes in gene position are accompanied by a change in time of replication.
    Cell. 1984 Mar;36(3):689-96 PMID: 6421490
  29. T-antigen-independent replication of polyomavirus DNA in murine embryonal carcinoma cells.
    Mol Cell Biol. 1984 Feb;4(2):317-23 PMID: 6321958
  30. Growth regulation of a cellular tumour antigen, p53, in nontransformed cells.
    Nature. 1984 Mar 8-14;308(5955):199-201 PMID: 6366574
  31. Manipulation of medium conditions and differentiation in the rat myogenic cell line L6.
    Dev Biol. 1984 Apr;102(2):269-77 PMID: 6706000
  32. Differences in evolutionary stability among mammalian H1 subtypes. Implications for the roles of H1 subtypes in chromatin.
    J Biol Chem. 1984 Jan 10;259(1):669-72 PMID: 6706958
  33. Replication timing of genes and middle repetitive sequences.
    Science. 1984 May 18;224(4650):686-92 PMID: 6719109
  34. The role of stable complexes that repress and activate eucaryotic genes.
    Cell. 1984 Jun;37(2):359-65 PMID: 6722879
  35. Reprogramming cell differentiation in the absence of DNA synthesis.
    Cell. 1984 Jul;37(3):879-87 PMID: 6744415
  36. Down-regulation of histone H3 and H4 gene transcription in differentiated L6 myotubes.
    Biochim Biophys Acta. 1989 Nov 2;1009(2):177-83 PMID: 2553101
  37. Transcriptional activator nuclear factor I stimulates the replication of SV40 minichromosomes in vivo and in vitro.
    Cell. 1989 Nov 3;59(3):541-51 PMID: 2553273
  38. Epigenetic inheritance of transcriptional states in S. cerevisiae.
    Cell. 1989 Nov 17;59(4):637-47 PMID: 2684414
  39. Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.
    EMBO J. 1989 Dec 1;8(12):3617-25 PMID: 2583111
  40. Similarity between the transcriptional silencer binding proteins ABF1 and RAP1.
    Science. 1989 Nov 24;246(4933):1034-8 PMID: 2511628
  41. An antisense RNA involved in p53 mRNA maturation in murine erythroleukemia cells induced to differentiate.
    EMBO J. 1989 Dec 20;8(13):4107-14 PMID: 2480234
  42. The role of ACE3 in Drosophila chorion gene amplification.
    EMBO J. 1989 Dec 20;8(13):4153-62 PMID: 2556262
  43. Analysis of fidelity mechanisms with eukaryotic DNA replication and repair proteins.
    Genome. 1989;31(1):100-3 PMID: 2687085
  44. Mutations in the p53 gene occur in diverse human tumour types.
    Nature. 1989 Dec 7;342(6250):705-8 PMID: 2531845
  45. Eukaryotic DNA polymerases alpha and delta: conserved properties and interactions, from yeast to mammalian cells.
    Prog Nucleic Acid Res Mol Biol. 1989;37:235-80 PMID: 2505329
  46. Enhancement of bacteriophage T4 late transcription by components of the T4 DNA replication apparatus.
    Science. 1989 Sep 1;245(4921):952-8 PMID: 2672335
  47. Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.
    Differentiation. 1989 Jun;40(3):191-7 PMID: 2570724
  48. Origin auxiliary sequences can facilitate initiation of simian virus 40 DNA replication in vitro as they do in vivo.
    Mol Cell Biol. 1989 Sep;9(9):3593-602 PMID: 2550797
  49. Different 3'-end processing produces two independently regulated mRNAs from a single H1 histone gene.
    Proc Natl Acad Sci U S A. 1989 Sep;86(18):7002-6 PMID: 2780558
  50. Transcriptional activation of bacteriophage lambda DNA replication in vitro: regulatory role of histone-like protein HU of Escherichia coli.
    EMBO J. 1989 Aug;8(8):2393-402 PMID: 2529119
  51. Polyomavirus genome and polyomavirus enhancer-driven gene expression during myogenesis.
    J Virol. 1989 Nov;63(11):4890-7 PMID: 2552161
  52. Evolution: generating novelty by symbiosis.
    Nature. 1989 Sep 28;341(6240):284-5 PMID: 2797144
  53. A nuclear DNA attachment element mediates elevated and position-independent gene activity.
    Nature. 1989 Sep 28;341(6240):343-5 PMID: 2797152
  54. The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias.
    Science. 1989 Oct 20;246(4928):379-82 PMID: 2799390
  55. The molecular control of normal and leukemic hematopoiesis: myeloid cells as a model system.
    Ann N Y Acad Sci. 1989;567:141-53 PMID: 2679315
  56. The beta-globin dominant control region.
    Prog Clin Biol Res. 1989;316A:37-46 PMID: 2687892
  57. The human HOX gene family.
    Nucleic Acids Res. 1989 Dec 25;17(24):10385-402 PMID: 2574852
  58. Cell type-dependent difference in the distribution and frequency of aphidicolin-induced fragile sites: T and B lymphocytes and bone marrow cells.
    Hum Genet. 1989 Dec;84(1):71-4 PMID: 2514134
  59. Genetic analysis of the enhancer requirements for polyomavirus DNA replication in mice.
    J Virol. 1990 Feb;64(2):476-85 PMID: 2153218
  60. Competition between transcription complex assembly and chromatin assembly on replicating DNA.
    EMBO J. 1990 Feb;9(2):573-82 PMID: 2303043
  61. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.
    J Virol. 1990 Mar;64(3):1353-6 PMID: 2154613
  62. Replication-dependent transactivation of the polyomavirus late promoter.
    J Virol. 1990 Mar;64(3):992-1001 PMID: 2154625
  63. In vitro replication through nucleosomes without histone displacement.
    Nature. 1990 Feb 22;343(6260):719-26 PMID: 2304549
  64. DNA amplification is rare in normal human cells.
    Proc Natl Acad Sci U S A. 1990 Mar;87(5):1791-5 PMID: 2308938
  65. Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter.
    Cell. 1990 Mar 9;60(5):719-31 PMID: 2155706
  66. Possible molecular mechanism for cell differentiation in multicellular organisms.
    J Theor Biol. 1971 Feb;30(2):337-93 PMID: 5555592
  67. Gene expression. Chromatin contract to silence.
    Nature. 1990 Mar 15;344(6263):193-4 PMID: 2107401
  68. Alternative chromatin structure at CpG islands.
    Cell. 1990 Mar 23;60(6):909-20 PMID: 2317863
  69. Transcriptional regulation by dimerization: two sides to an incestuous relationship.
    Cell. 1990 Apr 6;61(1):9-11 PMID: 2180585
  70. Effect of cell history on response to helix-loop-helix family of myogenic regulators.
    Nature. 1990 Mar 29;344(6265):454-8 PMID: 2157160
  71. Autonomous replication of a DNA fragment containing the chromosomal replication origin of the human c-myc gene.
    Nucleic Acids Res. 1990 Mar 11;18(5):1233-42 PMID: 2157194
  72. Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.
    Proc Natl Acad Sci U S A. 1990 Apr;87(7):2770-4 PMID: 2320588
  73. DNA methylation and chromatin structure: a view from below.
    Trends Biochem Sci. 1990 Mar;15(3):103-7 PMID: 2139257
  74. The structure and assembly of active chromatin.
    Trends Genet. 1990 Feb;6(2):52-6 PMID: 2186529
  75. Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate.
    Proc Natl Acad Sci U S A. 1990 May;87(10):3977-81 PMID: 2160080
  76. The three most downstream genes of the Hox-3 cluster are expressed in human extraembryonic tissues including trophoblast of androgenetic origin.
    Development. 1990 Mar;108(3):471-7 PMID: 1971215
  77. Ectopic expression of c-jun leads to differentiation of P19 embryonal carcinoma cells.
    EMBO J. 1990 Jun;9(6):1831-7 PMID: 2161334
  78. Differential expression of jun and fos genes during differentiation of mouse P19 embryonal carcinoma cells.
    Nucleic Acids Res. 1990 Jun 11;18(11):3195-202 PMID: 2113273
  79. Cell proliferation inhibited by MyoD1 independently of myogenic differentiation.
    Nature. 1990 Jun 28;345(6278):813-5 PMID: 2359457
  80. Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation.
    Cell. 1990 Jul 13;62(1):175-85 PMID: 2163767
  81. A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation.
    EMBO J. 1990 Aug;9(8):2579-85 PMID: 1973385
  82. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts.
    Science. 1990 Aug 10;249(4969):666-9 PMID: 2166342
  83. Mapping an origin of DNA replication at a single-copy locus in exponentially proliferating mammalian cells.
    Mol Cell Biol. 1990 Sep;10(9):4685-9 PMID: 2388621
  84. An initiation zone of chromosomal DNA replication located upstream of the c-myc gene in proliferating HeLa cells.
    Mol Cell Biol. 1990 Sep;10(9):4899-904 PMID: 2201906
  85. Minimal subenhancer requirements for high-level polyomavirus DNA replication: a cell-specific synergy of PEA3 and PEA1 sites.
    Mol Cell Biol. 1990 Sep;10(9):4996-5001 PMID: 2167444
  86. Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells.
    Nature. 1990 Aug 23;346(6286):763-6 PMID: 1975088
  87. Human globin locus activation region (LAR): role in temporal control.
    Trends Genet. 1990 Jul;6(7):219-23 PMID: 2202110
  88. Regulation of the genes of the bithorax complex in Drosophila.
    Cold Spring Harb Symp Quant Biol. 1985;50:155-64 PMID: 3868476
  89. Domains of cis-interaction in the bithorax complex.
    Cold Spring Harb Symp Quant Biol. 1985;50:173-80 PMID: 3938360
  90. Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice.
    Cold Spring Harb Symp Quant Biol. 1985;50:399-409 PMID: 3006998
  91. Coordinate expression of myogenic functions and polyoma virus replication.
    Cold Spring Harb Symp Quant Biol. 1985;50:753-7 PMID: 3007014
  92. Genetic, biochemical, and molecular approaches to Volvox development and evolution.
    Int Rev Cytol. 1986;99:217-93 PMID: 3514509
  93. Developmentally regulated expression of Drosophila chorion genes introduced at diverse chromosomal positions.
    J Mol Biol. 1986 Jan 5;187(1):33-45 PMID: 2420996
  94. Permanent attachment of replication origins to the nuclear matrix in BHK-cells.
    Nucleic Acids Res. 1986 Apr 25;14(8):3241-9 PMID: 3703674
  95. Role of DNA polymerase alpha and DNA primase in simian virus 40 DNA replication in vitro.
    Proc Natl Acad Sci U S A. 1986 May;83(9):2869-73 PMID: 3010320
  96. Temporal order of replication of Xenopus laevis 5S ribosomal RNA genes in somatic cells.
    Proc Natl Acad Sci U S A. 1986 May;83(9):2924-8 PMID: 3458252
  97. The relationship between chromosomal origins of replication and the nuclear matrix during the cell cycle.
    Exp Cell Res. 1986 Jun;164(2):426-36 PMID: 2940105
  98. CpG-rich islands and the function of DNA methylation.
    Nature. 1986 May 15-21;321(6067):209-13 PMID: 2423876
  99. The bovine papillomavirus replicon.
    Ciba Found Symp. 1986;120:53-67 PMID: 3013526
  100. Transcription-induced nucleosome 'splitting': an underlying structure for DNase I sensitive chromatin.
    EMBO J. 1991 Mar;10(3):607-15 PMID: 2001676
  101. Polyomavirus DNA replication in the pancreas and in a transformed pancreas cell line has distinct enhancer requirements.
    J Virol. 1991 Apr;65(4):2108-12 PMID: 1848321
  102. Imprinting a determined state into the chromatin of Drosophila.
    Trends Genet. 1990 Dec;6(12):416-21 PMID: 1982376
  103. Position-effect variegation after 60 years.
    Trends Genet. 1990 Dec;6(12):422-6 PMID: 2087785
  104. The initiation of chromosomal DNA replication in eukaryotes.
    Trends Genet. 1990 Dec;6(12):427-32 PMID: 2087786
  105. E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.
    J Virol. 1991 Jun;65(6):2921-8 PMID: 1851864
  106. Host range specificity of polyomavirus EC mutants in mouse embryonal carcinoma and embryonal stem cells and preimplantation embryos.
    J Virol. 1991 Jun;65(6):3029-43 PMID: 1851869
  107. Blocking cell division does not remove the requirement for Polycomb function in Drosophila embryogenesis.
    Development. 1990 Dec;110(4):1319-25 PMID: 1983118
  108. From gene to chromosome: organization levels defined by the interplay of transcription and replication in vertebrates.
    New Biol. 1990 Nov;2(11):937-45 PMID: 2101632
  109. Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells.
    Nature. 1991 Jan 31;349(6308):429-31 PMID: 1671528
  110. Multistep pathway for replication-dependent nucleosome assembly.
    Proc Natl Acad Sci U S A. 1989 Sep;86(17):6459-63 PMID: 2771936
  111. Influence of bromodeoxyuridine on the stability and function of polytene chromosomes.
    Chromosoma. 1977 Apr 27;61(1):75-94 PMID: 885028
  112. Cell polyploidy: its relation to tissue growth and function.
    Int Rev Cytol. 1977;50:275-332 PMID: 332657
  113. Virus infection of murine teratocarcinoma stem cell lines.
    Cell. 1977 Dec;12(4):973-82 PMID: 202395
  114. Infection of mouse preimplantation embryos with simian virus 40 and polyoma virus.
    Proc Natl Acad Sci U S A. 1978 Feb;75(2):999-1003 PMID: 204944
  115. Eucaryotic DNA: organization of the genome for replication.
    Cell. 1978 Oct;15(2):317-25 PMID: 719745
  116. A gene complex controlling segmentation in Drosophila.
    Nature. 1978 Dec 7;276(5688):565-70 PMID: 103000
  117. Assembly of newly replicated chromatin.
    Cell. 1978 Nov;15(3):969-77 PMID: 103629
  118. Differential replication of ribosomal gene repeats in polytene nuclei of Drosophila.
    Cell. 1979 Jul;17(3):597-605 PMID: 113105
  119. Involvement of eucaryotic deoxyribonucleic acid polymerases alpha and gamma in the replication of cellular and viral deoxyribonucleic acid.
    Biochemistry. 1979 Oct 2;18(20):4431-43 PMID: 226127
  120. The asymmetric segregation of parental nucleosomes during chrosome replication.
    Cell. 1979 Oct;18(2):439-49 PMID: 227608
  121. Assembly of an active chromatin structure during replication.
    Nucleic Acids Res. 1979 Oct 10;7(3):781-92 PMID: 503846
  122. A fixed site of DNA replication in eucaryotic cells.
    Cell. 1980 Feb;19(2):527-36 PMID: 7357619
  123. Implications of some genetic control mechanisms in Neurospora.
    Microbiol Rev. 1979 Sep;43(3):361-83 PMID: 232242
  124. Multienzyme complex for metabolic channeling in mammalian DNA replication.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3312-16 PMID: 6251456
  125. Supercoiled loops and eucaryotic DNA replicaton.
    Cell. 1980 Nov;22(1 Pt 1):79-85 PMID: 7428042
  126. Growth-regulatory control of human cell hybrids in nude mice.
    Cancer Res. 1981 Feb;41(2):573-80 PMID: 7448804
  127. Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells.
    Cell. 1981 Mar;23(3):809-14 PMID: 6261957
  128. DNA is replicated at the nuclear cage.
    J Cell Sci. 1980 Dec;46:365-86 PMID: 7228913
  129. Chromatin assembly. Relationship of chromatin structure to DNA sequence during simian virus 40 replication.
    J Biol Chem. 1981 Aug 25;256(16):8821-8 PMID: 6267052
  130. Replication of adeno-associated virus in synchronized cells without the addition of a helper virus.
    J Virol. 1987 Apr;61(4):972-81 PMID: 3029431
  131. lambda Repressor and cro--components of an efficient molecular switch.
    Nature. 1981 Nov 19;294(5838):217-23 PMID: 6457992
  132. DNA polymerase beta involvement in DNA endoreduplication in rat giant trophoblast cells.
    J Biol Chem. 1982 Feb 25;257(4):1785-90 PMID: 7056745
  133. Replication of viral DNA sequences integrated within the chromatin of SV40-transformed Chinese hamster lung cells.
    Cell. 1981 Oct;26(2 Pt 2):245-58 PMID: 6277496
  134. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
    Proc Natl Acad Sci U S A. 1981 Dec;78(12):7634-8 PMID: 6950406
  135. The H1 histones and their interphase phosphorylated states in differentiated and undifferentiated cell lines derived from murine teratocarcinomas.
    J Biol Chem. 1982 May 10;257(9):5183-9 PMID: 7068681
  136. The control of globin and other eukaryotic genes.
    J Cell Physiol Suppl. 1982;1:137-43 PMID: 6175650
  137. Tumor viruses and early mouse embryos.
    Biochim Biophys Acta. 1982 Apr 29;651(2-3):105-41 PMID: 6284213
  138. Assembly of transcriptionally active 5S RNA gene chromatin in vitro.
    Cell. 1982 Apr;28(4):781-91 PMID: 7201351
  139. The role of differentiation in the suppression of tumorigenicity in human cell hybrids.
    Int J Cancer. 1982 Jul 15;30(1):113-20 PMID: 7118295
  140. Gene amplification and drug resistance in mammalian cells.
    Natl Cancer Inst Monogr. 1982;60:79-86 PMID: 7121575
  141. Patterns of DNA replication of human chromosomes. II. Replication map and replication model.
    Am J Hum Genet. 1982 Sep;34(5):757-80 PMID: 7124731
  142. Studies on differentiation without cleavage in Chaetopterus. Requirement for a definite number of DNA replication cycles shown by aphidicolin pulses.
    Differentiation. 1982;22(2):132-5 PMID: 6813172
  143. Hormonal stimulation of myoblast differentiation in the absence of DNA synthesis.
    Am J Physiol. 1982 Nov;243(5):C278-84 PMID: 6753603
  144. Evidence for the direct involvement of DNA replication origin in synthesis of late SV40 RNA.
    Nature. 1982 Dec 9;300(5892):500-5 PMID: 6292733
  145. Induction of differentiation of human myeloid leukemia cells by inhibitors of DNA synthesis.
    Exp Hematol. 1982 Oct;10(9):774-81 PMID: 6816625
  146. The histone H1 complements of dividing and nondividing cells of the mouse.
    J Biol Chem. 1983 Jan 10;258(1):262-8 PMID: 6848501
  147. Effects of DNA polymerase inhibitors on replicative and repair DNA synthesis in ultraviolet-irradiated HeLa cells.
    Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Nov;42(5):471-80 PMID: 6818174
  148. Characterization of Giemsa dark- and light-band DNA.
    Cell. 1982 Nov;31(1):121-9 PMID: 7159923
  149. Stability of the conservative mode of nucleosome assembly.
    Nucleic Acids Res. 1983 May 11;11(9):2717-32 PMID: 6856473
  150. Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis.
    J Cell Sci. 1983 May;61:31-70 PMID: 6411748
  151. Chromatin assembled in the presence of cytosine arabinoside has a short nucleosome repeat.
    Nucleic Acids Res. 1983 Aug 25;11(16):5451-66 PMID: 6889133
  152. Repair of benzo[a]pyrene-initiated DNA damage in human cells requires activation of DNA polymerase alpha.
    Mutat Res. 1987 Sep;184(2):129-37 PMID: 3041206
  153. Developmental and hormonal regulation of neuroendocrine gene transcription.
    Recent Prog Horm Res. 1987;43:499-534 PMID: 3306840
  154. The origin of bidirectional DNA replication in polyoma virus.
    EMBO J. 1987 Jul;6(7):2011-8 PMID: 2820716
  155. The effect of retinoic acid pretreatment on the ability of murine embryonal carcinoma and inner cell mass cells to participate in chimaera development.
    J Embryol Exp Morphol. 1986 Nov;98:99-110 PMID: 3655654
  156. p53 and DNA polymerase alpha compete for binding to SV40 T antigen.
    Nature. 1987 Oct 1-7;329(6138):456-8 PMID: 3309672
  157. Mouse p53 inhibits SV40 origin-dependent DNA replication.
    Nature. 1987 Oct 1-7;329(6138):458-60 PMID: 2821401
  158. The inheritance of epigenetic defects.
    Science. 1987 Oct 9;238(4824):163-70 PMID: 3310230
  159. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice.
    Science. 1987 Oct 9;238(4824):188-93 PMID: 2821617
  160. Absence of DNA overreplication in Chinese hamster cells incubated with inhibitors of DNA synthesis.
    Cancer Res. 1987 Nov 1;47(21):5595-9 PMID: 3664465
  161. Inhibition of mammalian DNA polymerases by recombinant alpha-interferon and gamma-interferon.
    Cancer Res. 1987 Nov 15;47(22):5971-4 PMID: 3117359
  162. Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter.
    EMBO J. 1987 Aug;6(8):2321-8 PMID: 2822386
  163. The distribution of a 'mitosis-specific' antigen during Drosophila development.
    J Cell Sci. 1987 Feb;87 ( Pt 1):95-104 PMID: 3312250
  164. The transcriptional regulation of Xenopus 5s RNA genes in chromatin: the roles of active stable transcription complexes and histone H1.
    Cell. 1984 Jul;37(3):903-13 PMID: 6540147
  165. A DNA polymerase alpha partially resistant to aphidicolin in cells and embryos of Med-fly (Ceratitis capitata Wied.).
    Biochem Int. 1983 Oct;7(4):481-91 PMID: 6435630
  166. Spatial distribution of DNA loop attachment and replicational sites in the nuclear matrix.
    J Cell Biol. 1984 Nov;99(5):1794-802 PMID: 6490720
  167. Polyoma virus DNA replication requires an enhancer.
    Nature. 1984 Nov 15-21;312(5991):242-6 PMID: 6095089
  168. Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53.
    Nature. 1984 Dec 13-19;312(5995):651-4 PMID: 6095117
  169. Increased DNA polymerase beta-activity in different regions of aging rat brain.
    Biochem Int. 1984 Sep;9(3):391-7 PMID: 6439206
  170. Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma.
    Cell. 1984 Dec;39(3 Pt 2):653-62 PMID: 6096017
  171. Feline panleukopenia virus replicates in cells in which cellular DNA synthesis is blocked.
    J Virol. 1985 Feb;53(2):345-9 PMID: 2982022
  172. The OR control system of bacteriophage lambda. A physical-chemical model for gene regulation.
    J Mol Biol. 1985 Jan 20;181(2):211-30 PMID: 3157005
  173. Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9441-5 PMID: 2687881
  174. Reversible chromosome condensation induced in Drosophila embryos by anoxia: visualization of interphase nuclear organization.
    J Cell Biol. 1985 May;100(5):1623-36 PMID: 3921555
  175. Polyomavirus enhancer contains multiple redundant sequence elements that activate both DNA replication and gene expression.
    Mol Cell Biol. 1985 Apr;5(4):649-58 PMID: 2985964
  176. Transcription control by oncogenes.
    Cell. 1985 May;41(1):3-5 PMID: 2986847
  177. c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts.
    J Biol Chem. 1985 May 25;260(10):6404-9 PMID: 3997829
  178. Muscle gene expression in heterokaryons.
    Adv Exp Med Biol. 1985;182:231-47 PMID: 4003160
  179. Segments of chromosomal DNA from Rhynchosciara americana that undergo additional rounds of DNA replication in the salivary gland DNA puffs have only weak ARS activity in yeast.
    Gene. 1985;34(1):81-6 PMID: 3891517
  180. Common features of polyomavirus mutants selected on PCC4 embryonal carcinoma cells.
    EMBO J. 1985 Jul;4(7):1799-803 PMID: 2992943
  181. Purification and characterization of a DNA polymerase beta from Drosophila*.
    J Biol Chem. 1985 Sep 5;260(19):10406-11 PMID: 3928621
  182. Host species specificity of polyomavirus DNA replication is not altered by simian virus 40 72-base-pair repeats.
    Mol Cell Biol. 1985 Jun;5(6):1534-7 PMID: 2993870
  183. Simian virus 40 replication in adenovirus-transformed human cells antagonizes gene expression.
    Nature. 1985 Sep 12-18;317(6033):169-71 PMID: 2993921
  184. Repression of simian virus 40 early transcription by viral DNA replication in human 293 cells.
    Nature. 1985 Sep 12-18;317(6033):172-5 PMID: 2993922
  185. Involvement of DNA-polymerase activities in mouse-blastocyst differentiation in vitro.
    Differentiation. 1985;29(2):152-9 PMID: 3930334
  186. Mapping of the pattern of DNA replication in polytene chromosome from Chironomus thummi using monoclonal anti-bromodeoxyuridine antibodies.
    Cytometry. 1985 Nov;6(6):584-90 PMID: 3905301
  187. Cellular targets for SV40 large T-antigen.
    Proc R Soc Lond B Biol Sci. 1985 Oct 22;226(1242):25-42 PMID: 2415984
  188. The abdominal region of the bithorax complex.
    Cell. 1985 Nov;43(1):81-96 PMID: 3935319
  189. Tumor induction in transplanted tooth buds infected with polyoma virus.
    J Natl Cancer Inst. 1966 Jun;36(6):1121-36 PMID: 4287623
  190. Influence of epithelio-mesenchymal interactions on tumor induction by polyoma virus.
    Int J Cancer. 1966 Sep 15;1(5):419-50 PMID: 4287947
  191. Effect of ultraviolet irradiation on bacteriophage lambda immunity.
    J Mol Biol. 1967 Jan 28;23(2):247-63 PMID: 5340187
  192. Gene regulation for higher cells: a theory.
    Science. 1969 Jul 25;165(3891):349-57 PMID: 5789433
  193. Changes i chromosomal DNA replication tterns in developing frog embryos.
    J Exp Zool. 1970 May;174(1):101-13 PMID: 5444565
  194. When polymerases collide: replication and the transcriptional organization of the E. coli chromosome.
    Cell. 1988 Jun 3;53(5):679-86 PMID: 3286014
  195. General model for the chromosomes of higher organisms.
    Nature. 1971 Nov 5;234(5323):25-7 PMID: 4942881
  196. The biochemistry of differentiation of mouse trophoblast: studies on polyploidy.
    J Embryol Exp Morphol. 1972 Apr;27(2):447-65 PMID: 5061668
  197. Mechanism of accumulation of DNA in giant cells of mouse trophoblast.
    Nat New Biol. 1972 Aug 9;238(84):175-6 PMID: 4505986
  198. The cell cycle, cell lineages, and cell differentiation.
    Curr Top Dev Biol. 1972;7:229-56 PMID: 4264706
  199. Independent control of ribosomal gene replication in polytene chromosomes of Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1973 May;70(5):1359-63 PMID: 4197090
  200. Replication in polytene chromosomes.
    Results Probl Cell Differ. 1972;4:59-85 PMID: 4198832
  201. DNA replication in the chromosomes of eukaryotes.
    Cold Spring Harb Symp Quant Biol. 1974;38:195-203 PMID: 4598637
  202. The genes for ribosomal RNA in diploid and polytene chromosomes of Drosophila melanogaster.
    Chromosoma. 1974;48(2):159-79 PMID: 4218160
  203. The general affinity of lac repressor for E. coli DNA: implications for gene regulation in procaryotes and eucaryotes.
    Cell. 1975 Feb;4(2):107-11 PMID: 1092468
  204. Polytene chromosomes of Oxytricha: biochemical and morphological changes during macronuclear development in a ciliated protozoan.
    Chromosoma. 1976 JAN 27;54(1):1-13 PMID: 813980
  205. Lineages, quantal cell cycles, and the generation of cell diversity.
    Q Rev Biophys. 1975 Nov;8(4):523-57 PMID: 769044
  206. Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogaster.
    Cell. 1976 Nov;9(3):393-407 PMID: 825231
  207. Conformational constraints in nuclear DNA.
    J Cell Sci. 1976 Nov;22(2):287-302 PMID: 1033937
  208. Effect of cytosine arabinoside on replicon initiation in human lymphoblasts.
    Biochem Biophys Res Commun. 1977 Jan 10;74(1):72-8 PMID: 836288
  209. Polyoma regulatory region: a potential probe for mouse cell differentiation.
    Cell. 1985 Dec;43(3 Pt 2):561-2 PMID: 3000610
  210. Induction of myogenic differentiation in serum-free medium does not require DNA synthesis.
    Dev Biol. 1985 Apr;108(2):284-9 PMID: 3908188
  211. Gene gating: a hypothesis.
    Proc Natl Acad Sci U S A. 1985 Dec;82(24):8527-9 PMID: 3866238
  212. Structure of the 30 nm chromatin fiber.
    Cell. 1986 Feb 14;44(3):375-7 PMID: 3510744
  213. Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter.
    Nature. 1986 Jan 16-22;319(6050):246-8 PMID: 3945313
  214. Selection of mouse neuroblastoma cell-specific polyoma virus mutants with stage differentiative advantages of replication.
    EMBO J. 1985 Dec 1;4(12):3215-21 PMID: 3004942
  215. Replication intermediates formed during initiation of DNA synthesis in methotrexate-resistant CHOC 400 cells are enriched for sequences derived from a specific, amplified restriction fragment.
    Biochemistry. 1986 Jan 28;25(2):441-9 PMID: 3006761
  216. The production of tissue-specific histone complements during development.
    Biochem Cell Biol. 1988 Jun;66(6):636-49 PMID: 3048335
  217. Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast.
    Cell. 1988 Oct 7;55(1):27-39 PMID: 3048701
  218. Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly.
    Cell. 1988 Oct 21;55(2):211-9 PMID: 2844412
  219. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.
    Science. 1988 Oct 21;242(4877):405-11 PMID: 3175662
  220. Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus.
    Cell. 1988 Nov 4;55(3):427-33 PMID: 2846181
  221. Highly efficient beta globin transcription in the absence of both a viral enhancer and erythroid factors.
    Development. 1987 Dec;101(4):815-27 PMID: 2460304
  222. Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome.
    EMBO J. 1988 Oct;7(10):3073-9 PMID: 2846275
  223. An initiation site of DNA replication with transcriptional enhancer activity present upstream of the c-myc gene.
    EMBO J. 1988 Oct;7(10):3135-42 PMID: 3053161
  224. DNA polymerase beta in human thyroid of Graves' disease and thyroid tumors.
    Metabolism. 1988 Nov;37(11):1051-4 PMID: 3185287
  225. Characterization of the repressed 5S DNA minichromosomes assembled in vitro with a high-speed supernatant of Xenopus laevis oocytes.
    Mol Cell Biol. 1988 Oct;8(10):4257-69 PMID: 3185548
  226. On the displacement of histones from DNA by transcription.
    Cell. 1988 Dec 2;55(5):743-4 PMID: 3191529
  227. The need for enhancers is acquired upon formation of a diploid nucleus during early mouse development.
    Genes Dev. 1988 Sep;2(9):1115-26 PMID: 2847960
  228. Early replication and expression of oocyte-type 5S RNA genes in a Xenopus somatic cell line carrying a translocation.
    Proc Natl Acad Sci U S A. 1986 Jul;83(14):5150-4 PMID: 3460086
  229. Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: implications for gene amplification.
    Cancer Res. 1986 Sep;46(9):4607-12 PMID: 3731112
  230. Rapid reprogramming of globin gene expression in transient heterokaryons.
    Cell. 1986 Aug 15;46(4):591-602 PMID: 3731277
  231. Multiple DNA-protein interactions governing high-precision DNA transactions.
    Science. 1986 Sep 5;233(4768):1050-6 PMID: 2943018
  232. Negative control of DNA replication in composite SV40-bovine papilloma virus plasmids.
    Cell. 1986 Aug 29;46(5):741-52 PMID: 3017566
  233. Differentiation of lens and neural cells in chicken embryos is accompanied by simultaneous decay of DNA replication machinery.
    Dev Biol. 1986 Sep;117(1):226-32 PMID: 3527815
  234. The genetic analysis of malignancy.
    J Cell Sci Suppl. 1986;4:431-44 PMID: 3528200
  235. Analysis of an activatable promoter: sequences in the simian virus 40 late promoter required for T-antigen-mediated trans activation.
    Mol Cell Biol. 1985 Aug;5(8):1859-69 PMID: 3018532
  236. Polyomavirus mutation that confers a cell-specific cis advantage for viral DNA replication.
    Mol Cell Biol. 1985 Aug;5(8):2142-6 PMID: 3018552
  237. Asynchronous duplication of chromosomes in cultured cells of Chinese hamster.
    J Biophys Biochem Cytol. 1960 Jun;7:455-64 PMID: 13837165
  238. Transcriptional selectivity of viral genes in mammalian cells.
    Cell. 1986 Sep 12;46(6):795-805 PMID: 3530495
  239. Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain.
    Proc Natl Acad Sci U S A. 1986 Oct;83(20):7790-4 PMID: 3094015
  240. DNA replication in vitro erases a Xenopus 5S RNA gene transcription complex.
    Cell. 1986 Oct 24;47(2):217-27 PMID: 3021334
  241. Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element.
    Cell. 1986 Oct 24;47(2):229-40 PMID: 3768955
  242. Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells.
    Cell. 1986 Nov 7;47(3):391-9 PMID: 3768959
  243. Murine erythroblasts do not contain histone H10.
    Dev Biol. 1986 Nov;118(1):319-23 PMID: 3770306
  244. Replication origins are attached to the nuclear skeleton.
    Nucleic Acids Res. 1986 Oct 24;14(20):8189-207 PMID: 3774556
  245. An intervening sequence in an unusual histone H1 gene of Tetrahymena thermophila.
    Proc Natl Acad Sci U S A. 1986 Nov;83(22):8674-8 PMID: 3464976
  246. Transcription activation by viral and cellular oncogenes.
    Adv Cancer Res. 1986;47:283-96 PMID: 3022565
  247. The anterobithorax and bithorax mutations of the bithorax complex.
    EMBO J. 1986 Sep;5(9):2293-303 PMID: 3023068
  248. Lymphoid and other tissue-specific phenotypes of polyomavirus enhancer recombinants: positive and negative combinational effects on enhancer specificity and activity.
    Mol Cell Biol. 1986 Jun;6(6):2068-79 PMID: 3023917
  249. Control of HL-60 cell differentiation lineage specificity, a late event occurring after precommitment.
    Cancer Res. 1987 Jan 1;47(1):129-34 PMID: 3466687
  250. Distribution of S-phase cells during the regeneration of Drosophila imaginal wing discs.
    Dev Biol. 1987 Jan;119(1):137-42 PMID: 3098601
  251. New class of polyomavirus mutant that can persist as free copies in F9 embryonal carcinoma cells.
    Mol Cell Biol. 1986 Nov;6(11):3920-7 PMID: 3025619
  252. Drosophila chorion gene amplification requires an upstream region regulating s18 transcription.
    Mol Cell Biol. 1986 Dec;6(12):4624-33 PMID: 3099171
  253. A pancreas specificity results from the combination of polyomavirus and Moloney murine leukemia virus enhancer.
    Proc Natl Acad Sci U S A. 1987 Jan;84(2):449-53 PMID: 3025873
  254. Induction of transformed cells to terminal differentiation and the modulation of gene expression.
    Cancer Res. 1987 Feb 1;47(3):659-66 PMID: 3542191
  255. Hydroxyurea indices precommitment during retinoic induced HL-60 terminal myeloid differentiation: possible involvement of gene amplification.
    Leuk Res. 1987;11(1):63-71 PMID: 3468316
  256. Genomic reorganization in ciliated protozoans.
    Annu Rev Genet. 1986;20:501-21 PMID: 3101582
  257. DNA methylation and the regulation of aldolase B gene expression.
    J Biochem. 1986 Nov;100(5):1279-86 PMID: 3029054
  258. Genetic control of cell division patterns in the Drosophila embryo.
    Cell. 1989 Apr 7;57(1):177-87 PMID: 2702688
  259. Replication of proto-oncogenes early during the S phase in mammalian cell lines.
    Nucleic Acids Res. 1987 Jan 12;15(1):87-103 PMID: 3469620
  260. Competition for formation of nucleosomes on fragmented SV40 DNA: a hyperstable nucleosome forms on the termination region.
    Biochemistry. 1987 Jan 13;26(1):295-303 PMID: 3030401
  261. Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.
    Mol Cell Biol. 1987 Jan;7(1):450-7 PMID: 3031474
  262. Extended culture of mouse embryo cells without senescence: inhibition by serum.
    Science. 1987 Apr 10;236(4798):200-2 PMID: 3494308
  263. Role of replication time in the control of tissue-specific gene expression.
    Am J Hum Genet. 1987 Feb;40(2):151-73 PMID: 3551593
  264. Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones.
    Cell. 1987 Apr 24;49(2):203-10 PMID: 3568125
  265. Replicative cis-advantage of polyomavirus regulatory region mutants in different murine cell lines.
    J Virol. 1987 May;61(5):1615-20 PMID: 3033287
  266. Genetic engineering of mouse and human stem cells.
    Cold Spring Harb Symp Quant Biol. 1986;51 Pt 2:1083-91 PMID: 3472753
  267. Regulation of inducible and tissue-specific gene expression.
    Science. 1987 Jun 5;236(4806):1237-45 PMID: 3296191
  268. Amplification of the X-linked Drosophila chorion gene cluster requires a region upstream from the s38 chorion gene.
    EMBO J. 1987 Apr;6(4):1045-53 PMID: 3036489
  269. Transcription of adenovirus 2 major late and peptide IX genes under conditions of in vitro nucleosome assembly.
    Mol Cell Biol. 1987 Apr;7(4):1401-8 PMID: 3600631
  270. DNA sequence-directed nucleosome reconstitution on 5S RNA genes of Xenopus laevis.
    Mol Cell Biol. 1987 May;7(5):1612-22 PMID: 3600640
  271. Induction of a factor that binds to the polyoma virus A enhancer on differentiation of embryonal carcinoma cells.
    Nature. 1987 Jul 16-22;328(6127):254-6 PMID: 3037385
  272. c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
    Nucleic Acids Res. 1987 Jun 25;15(12):4889-99 PMID: 3037484
  273. 2',3'-Dideoxythymidine 5'-triphosphate inhibition of DNA replication and ultraviolet-induced DNA repair synthesis in human cells: evidence for involvement of DNA polymerase delta.
    Biochemistry. 1987 May 19;26(10):2664-8 PMID: 3606985
  274. Further characterization of the interaction of polyoma virus and simian virus 40 with embryonal carcinoma cells.
    Exp Mol Pathol. 1987 Aug;47(1):48-58 PMID: 3038593
  275. Characterization of a mutant polyoma that expresses in F9 embryonal carcinoma cells: morphology, tumorigenicity, and restriction enzyme analysis.
    Exp Mol Pathol. 1987 Aug;47(1):59-68 PMID: 3038594
  276. In vitro initiation of DNA replication in simian virus 40 chromosomes.
    J Biol Chem. 1987 Aug 5;262(22):10863-72 PMID: 3038899
  277. A bacteriophage RNA polymerase transcribes in vitro through a nucleosome core without displacing it.
    Cell. 1987 Aug 28;50(5):801-8 PMID: 3621345
  278. Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen.
    Cell. 1987 Sep 11;50(6):847-61 PMID: 3040262
  279. Over-replication of DNA in S phase Chinese hamster ovary cells after DNA synthesis inhibition.
    J Biol Chem. 1987 Sep 5;262(25):11927-34 PMID: 3114256
  280. Histone H5 in the control of DNA synthesis and cell proliferation.
    Science. 1989 Jul 7;245(4913):68-71 PMID: 2740916
  281. Rodent common fragile sites: are they conserved? Evidence from mouse and rat.
    Chromosoma. 1989 May;97(6):459-64 PMID: 2501072
  282. Cell differentiation and tumour suppression.
    Ciba Found Symp. 1989;142:217-31; discussion 231-3 PMID: 2787231
  283. The development potential of parthenogenetically derived cells in chimeric mouse embryos: implications for action of imprinted genes.
    Development. 1988 Sep;104(1):175-82 PMID: 3253058
  284. A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.
    Genes Dev. 1989 May;3(5):628-40 PMID: 2473006
  285. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.
    Proc Natl Acad Sci U S A. 1989 Jul;86(14):5434-8 PMID: 2748593
  286. Expression of muscle-specific proteins is necessary to regulate translation of the mRNA for a 40-kDa housekeeping polypeptide in rat L6 cells.
    Eur J Biochem. 1989 Jul 1;182(3):687-98 PMID: 2473901
  287. Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes.
    Nature. 1989 Aug 3;340(6232):393-7 PMID: 2547164
  288. Rapid induction of polyadenylated H1 histone mRNAs in mouse erythroleukemia cells is regulated by c-myc.
    Mol Cell Biol. 1989 Jun;9(6):2332-40 PMID: 2668731
  289. Evolution and stability of chromosomal DNA coamplified with the CAD gene.
    Mol Cell Biol. 1989 Jun;9(6):2445-52 PMID: 2569669
  290. Transcription factor IIIB generates extended DNA interactions in RNA polymerase III transcription complexes on tRNA genes.
    Mol Cell Biol. 1989 Jun;9(6):2551-66 PMID: 2668737
  291. Fibroblast-specific common fragile sites induced by aphidicolin.
    Hum Genet. 1989 Aug;83(1):45-8 PMID: 2504659
  292. Specific interaction of simian virus 40 large T antigen with cellular chromatin and nuclear matrix during the course of infection.
    J Virol. 1987 Nov;61(11):3561-9 PMID: 2822963
  293. Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II.
    Cell. 1987 Nov 20;51(4):613-22 PMID: 3677170
  294. A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation.
    Cell. 1987 Dec 4;51(5):709-19 PMID: 3315230
  295. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements.
    Cell. 1987 Dec 4;51(5):721-32 PMID: 3315231
  296. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene.
    Cell. 1987 Dec 4;51(5):773-81 PMID: 3677172
  297. Specific factors binding to the late E2A promoter region of adenovirus type 2 DNA: no apparent effects of 5'-CCGG-3' methylation.
    DNA. 1987 Oct;6(5):449-60 PMID: 2960507
  298. Precommitment states induced during HL-60 myeloid differentiation: possible similarities of retinoic acid- and DMSO-induced early events.
    Exp Cell Res. 1987 Nov;173(1):80-4 PMID: 3678385
  299. Amplification of a chorion gene cluster in Drosophila is subject to multiple cis-regulatory elements and to long-range position effects.
    J Mol Biol. 1987 Sep 5;197(1):11-26 PMID: 2824792
  300. Induction of lymphomas by the hamster papovavirus correlates with massive replication of nonrandomly deleted extrachromosomal viral genomes.
    J Virol. 1987 Dec;61(12):3992-8 PMID: 2824828
  301. Transgenic mice.
    Cell. 1985 Jun;41(2):343-5 PMID: 2985274
  302. The molecular control of blood cell development.
    Science. 1987 Dec 4;238(4832):1374-9 PMID: 3317831
  303. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.
    Science. 1987 Dec 4;238(4832):1386-92 PMID: 2825349
  304. Replication of plasmids derived from bovine papilloma virus type 1 and Epstein-Barr virus in cells in culture.
    Annu Rev Cell Biol. 1987;3:87-108 PMID: 2825737
  305. Position-independent, high-level expression of the human beta-globin gene in transgenic mice.
    Cell. 1987 Dec 24;51(6):975-85 PMID: 3690667
  306. Induction of HL-60 monocytic cell differentiation promoted by a perturbation of DNA synthesis: hydroxyurea promotes action of TPA.
    Exp Cell Res. 1988 Jan;174(1):98-106 PMID: 2826198
  307. Necrotizing arterial lesions in mice-bearing tumors induced by polyoma virus.
    J Exp Pathol. 1987 Spring;3(2):177-201 PMID: 2826731
  308. Significance of polyploidy in megakaryocytes and other cells in health and tumor disease.
    Klin Wochenschr. 1987 Dec 1;65(23):1115-31 PMID: 3323647
  309. Oligonucleotide that binds nuclear factor NF-kappa B acts as a lymphoid-specific and inducible enhancer element.
    Proc Natl Acad Sci U S A. 1988 Mar;85(5):1482-6 PMID: 3125549
  310. Human polyoma virus type BK infection and T antibody response in renal transplant recipients.
    Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Oct;266(3-4):567-74 PMID: 2830740
  311. Induction of transformed cells to terminal differentiation.
    Ann N Y Acad Sci. 1987;511:246-55 PMID: 3326466
  312. Transcriptional elements as components of eukaryotic origins of DNA replication.
    Cell. 1988 Mar 11;52(5):635-8 PMID: 3278812
  313. Regulation of DNA replication during Drosophila development.
    Annu Rev Genet. 1987;21:373-403 PMID: 3327470
  314. Nonrandom assembly of chromatin during hydroxyurea inhibition of DNA synthesis.
    Biochemistry. 1988 Jan 26;27(2):686-91 PMID: 3349057
  315. Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer.
    Proc Natl Acad Sci U S A. 1988 Apr;85(7):2120-4 PMID: 3281162
  316. Cell-cycle regulation as a mechanism for targeting proteins to specific DNA sequences in Tetrahymena thermophila.
    Proc Natl Acad Sci U S A. 1988 Apr;85(7):2205-9 PMID: 3353376
  317. Wound healing, cell communication, and DNA synthesis during imaginal disc regeneration in Drosophila.
    Dev Biol. 1988 May;127(1):197-208 PMID: 2452103
  318. Regulation of mouse satellite DNA replication time.
    EMBO J. 1988 Feb;7(2):419-26 PMID: 3366119
  319. Role for DNA replication in beta-globin gene activation.
    Mol Cell Biol. 1988 Mar;8(3):1301-8 PMID: 2835669
  320. A trans-acting factor represses the activity of the polyoma virus enhancer in undifferentiated embryonal carcinoma cells.
    Oncogene Res. 1987 Jul;1(2):113-9 PMID: 2835729
  321. DNA synthesis and the control of embryonic gene expression in C. elegans.
    Cell. 1988 May 20;53(4):589-99 PMID: 3131016
  322. Loss of bovine papillomavirus DNA replication control in growth-arrested transformed cells.
    J Virol. 1989 May;63(5):2215-25 PMID: 2539513
  323. [DNA replication and RNA transcription regulated by c-myc protein].
    Tanpakushitsu Kakusan Koso. 1988 Sep;33(11):1758-65 PMID: 2468174
  324. Promoter occlusion prevents transcription of adenovirus polypeptide IX mRNA until after DNA replication.
    Genes Dev. 1989 Jan;3(1):49-59 PMID: 2523329
  325. Opposite replication polarity of the germ line c-myc gene in HeLa cells compared with that of two Burkitt lymphoma cell lines.
    Mol Cell Biol. 1989 Feb;9(2):586-93 PMID: 2710118
  326. Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.
    Mol Cell Biol. 1989 Feb;9(2):851-3 PMID: 2710127
  327. Induction of macrophage-like differentiation of HL-60 leukemia cells by tumor necrosis factor-alpha: potential role of fos expression.
    Mol Endocrinol. 1989 Feb;3(2):409-19 PMID: 2496305
  328. Tissue specific phenotypes of polyomavirus A and B enhancer transpositions and duplications: positional and nonpositional effects on replication in lymphoid cells.
    Virus Genes. 1987 Nov;1(1):23-34 PMID: 2854320
  329. Comparative studies on repair inhibition by araA, araC and aphidicolin of radiation induced DNA and chromosome damage in rodent cells: comparison with fixation of PLD.
    Int J Radiat Oncol Biol Phys. 1989 May;16(5):1261-5 PMID: 2497095
  330. Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition.
    Nucleic Acids Res. 1989 Apr 11;17(7):2449-61 PMID: 2470025
  331. Hox and HOM: homologous gene clusters in insects and vertebrates.
    Cell. 1989 May 5;57(3):347-9 PMID: 2566382
  332. The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen.
    Cell. 1989 May 5;57(3):379-92 PMID: 2541911
  333. Two different chromatin structures coexist in ribosomal RNA genes throughout the cell cycle.
    Cell. 1989 Jun 2;57(5):753-61 PMID: 2720786
  334. Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases.
    Mol Pharmacol. 1989 May;35(5):578-83 PMID: 2471054
  335. Sea urchin early and late H4 histone genes bind a specific transcription factor in a stable preinitiation complex.
    Mol Cell Biol. 1989 Apr;9(4):1476-87 PMID: 2725512
  336. Localization of Epstein-Barr virus DNA in the epithelial cells of oral hairy leukoplakia by in situ hybridization of tissue sections.
    N Engl J Med. 1989 Jun 8;320(23):1559-60 PMID: 2542792
  337. Construction of large DNA segments in Escherichia coli.
    Science. 1989 Jun 16;244(4910):1307-12 PMID: 2660262
  338. Levels and size complexity of DNA polymerase beta mRNA in rat regenerating liver and other organs.
    Biochim Biophys Acta. 1989 Jul 7;1008(2):203-7 PMID: 2736248
  339. Recent progress in understanding mechanisms of mammalian DNA amplification.
    Cell. 1989 Jun 16;57(6):901-8 PMID: 2661014
  340. Mapping replication units in animal cells.
    Cell. 1989 Jun 16;57(6):909-20 PMID: 2544294
  341. The p53 proto-oncogene can act as a suppressor of transformation.
    Cell. 1989 Jun 30;57(7):1083-93 PMID: 2525423
  342. Pathways of nucleoprotein assembly on 5S RNA genes in a Xenopus oocyte S-150 extract.
    Nucleic Acids Res. 1989 Jun 12;17(11):4117-30 PMID: 2544856
  343. Is c-myc protein directly involved in DNA replication?
    Science. 1988 May 27;240(4856):1202-3 PMID: 3287614
  344. Cell lineage analysis in mammalian embryogenesis.
    Curr Top Dev Biol. 1987;23:115-46 PMID: 3330501
  345. Immunocytochemical localization of transient DNA strand breaks in differentiating myotubes using in situ nick-translation.
    Dev Biol. 1988 Jun;127(2):362-7 PMID: 3378668
  346. Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.
    Genes Dev. 1988 Mar;2(3):267-81 PMID: 3288540
  347. Simian virus 40 T antigen alters the binding characteristics of specific simian DNA-binding factors.
    Mol Cell Biol. 1988 Apr;8(4):1648-56 PMID: 2837651
  348. Opposite replication polarities of transcribed and nontranscribed histone H5 genes.
    Mol Cell Biol. 1988 Apr;8(4):1657-63 PMID: 3380091
  349. Functional analysis of the individual enhancer core sequences of polyomavirus: cell-specific uncoupling of DNA replication from transcription.
    Mol Cell Biol. 1988 May;8(5):1993-2004 PMID: 2838739
  350. Replication program of active and inactive multigene families in mammalian cells.
    Mol Cell Biol. 1988 May;8(5):2149-58 PMID: 3386634
  351. Inhibition of transcription in eukaryotic cells by X-irradiation: relation to the loss of topological constraint in closed DNA loops.
    Nucleic Acids Res. 1988 Jun 10;16(11):5175-90 PMID: 3387223
  352. Plasmid origin of replication of Epstein-Barr virus, oriP, does not limit replication in cis.
    Mol Biol Med. 1988 Apr;5(2):85-94 PMID: 2840551
  353. Transcription complexes that program Xenopus 5S RNA genes are stable in vivo.
    Proc Natl Acad Sci U S A. 1988 Aug;85(15):5516-20 PMID: 3399503
  354. Analysis of hamster lymphomas for the presence of hamster papovavirus DNA.
    Acta Virol. 1988 Mar;32(2):97-103 PMID: 2899969
  355. Visualization of Drosophila melanogaster chorion genes undergoing amplification.
    Mol Cell Biol. 1988 Jul;8(7):2811-21 PMID: 3136323
  356. Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis.
    Mol Cell Biol. 1988 Jul;8(7):2822-7 PMID: 3405220
  357. Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins.
    Proc Natl Acad Sci U S A. 1988 Aug;85(16):5839-43 PMID: 2842750
  358. Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III.
    Science. 1988 Sep 2;241(4870):1210-3 PMID: 3413485
  359. Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex.
    Cell. 1988 Sep 23;54(7):1033-42 PMID: 3416354
  360. Analysis of the role of the transcription factor ATF in the assembly of a functional preinitiation complex.
    Cell. 1988 Sep 23;54(7):1043-51 PMID: 3416355
  361. The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence.
    Cell. 1988 Sep 23;54(7):931-42 PMID: 2843293
  362. Polytene chromosomes in mouse trophoblast giant cells.
    Development. 1988 Jan;102(1):127-34 PMID: 3166422
  363. Developmental regulation of two 5S ribosomal RNA genes.
    Science. 1988 Sep 23;241(4873):1626-32 PMID: 3420414
  364. DNA sequence requirements for replication of polyomavirus DNA in vivo and in vitro.
    Mol Cell Biol. 1987 Oct;7(10):3694-704 PMID: 2824994
  365. Transfection of mouse erythroleukemia cells with myc sequences changes the rate of induced commitment to differentiate.
    Proc Natl Acad Sci U S A. 1986 Sep;83(17):6480-4 PMID: 3529085
  366. Tumor necrosis factor inhibits the terminal event in mesenchymal stem cell differentiation.
    J Cell Physiol. 1988 Nov;137(2):367-73 PMID: 3192620
  367. Hormonal regulation of DNA polymerase-beta activity in the rat thyroid gland.
    J Endocrinol. 1988 Nov;119(2):303-8 PMID: 3199062
  368. Comeasurement of simian virus 40 early and late promoter activity in HeLa and 293 cells in the presence of T antigen.
    J Virol. 1989 Jan;63(1):383-91 PMID: 2535739
  369. Common fragile sites induced by folate deprivation, BrdU and aphidicolin: their frequency and distribution in Japanese individuals.
    Jinrui Idengaku Zasshi. 1988 Sep;33(3):355-64 PMID: 3144619
  370. Xenopus transcription factor IIIA forms a complex of covalent character with 5S DNA.
    Nucleic Acids Res. 1988 Dec 9;16(23):11267-84 PMID: 3205743
  371. Presence of transcription signals in two putative DNA replication origins of human cells.
    Biochim Biophys Acta. 1988 Dec 20;951(2-3):430-42 PMID: 3145020
  372. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.
    J Virol. 1989 Feb;63(2):739-46 PMID: 2642977
  373. The coordinate replication of the human beta-globin gene domain reflects its transcriptional activity and nuclease hypersensitivity.
    Mol Cell Biol. 1988 Nov;8(11):4958-65 PMID: 2850471
  374. Multiple subelements within the polyomavirus enhancer function synergistically to activate DNA replication.
    Mol Cell Biol. 1988 Nov;8(11):5000-15 PMID: 2850472
  375. Ordering promoter binding of class III transcription factors TFIIIC1 and TFIIIC2.
    Mol Cell Biol. 1988 Aug;8(8):3017-25 PMID: 3145406
  376. Control elements of the P2 promoter of the Antennapedia gene.
    Genes Dev. 1988 Dec;2(12A):1600-14 PMID: 2905685
  377. A reduced rate of bulky DNA adduct removal is coincident with differentiation of human neuroblastoma cells induced by nerve growth factor.
    Mol Cell Biol. 1988 Sep;8(9):3964-8 PMID: 3146694
  378. Replication timing of 10 developmentally regulated genes in Physarum polycephalum.
    Nucleic Acids Res. 1989 Jan 25;17(2):553-66 PMID: 2915922
  379. A domain model for eukaryotic DNA organization: a molecular basis for cell differentiation and chromosome evolution.
    J Theor Biol. 1988 Jun 22;132(4):479-507 PMID: 3226138
  380. Differences in inhibition by beta-arabinofuranosyladenine (araA) of radiation induced DNA damage repair in exponentially growing and plateau-phase CHO-cells.
    Radiat Environ Biophys. 1988;27(4):295-305 PMID: 3227108
  381. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.
    Cell. 1989 Mar 10;56(5):777-83 PMID: 2493990
  382. Integrated control of proliferation and differentiation of mesenchymal stem cells.
    Environ Health Perspect. 1989 Mar;80:117-25 PMID: 2647473
  383. Stability of transcription complexes on class II genes.
    Mol Cell Biol. 1989 Jan;9(1):342-4 PMID: 2494433
  384. Modulation of the c-myb, c-myc and p53 mRNA and protein levels during induced murine erythroleukemia cell differentiation.
    Oncogene. 1989 Feb;4(2):165-73 PMID: 2648254
  385. Anti-OTF-1 antibodies inhibit NFIII stimulation of in vitro adenovirus DNA replication.
    Nucleic Acids Res. 1989 Mar 11;17(5):1845-63 PMID: 2928110
Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.55.3.512-542.1991
Published
1991-09-00
Pages
512-42
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC372832
Subset
IM
Grants
NIGMS NIH HHS · GM 36605 · United States
External Links
PubMed source DOI: 10.1128/mr.55.3.512-542.1991 PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2