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PMID: 26648264 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

A-to-I editing of coding and non-coding RNAs by ADARs.

Nature reviews. Molecular cell biology ·Vol. 17 ·No. 2 ·2016-02-00 ·Pages 83-96

Nishikura K

Abstract

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but also frequently in non-coding regions that contain inverted Alu repeats. Editing of coding sequences can result in the expression of functionally altered proteins that are not encoded in the genome, whereas the significance of Alu editing remains largely unknown. Certain microRNA (miRNA) precursors are also edited, leading to reduced expression or altered function of mature miRNAs. Conversely, recent studies indicate that ADAR1 forms a complex with Dicer to promote miRNA processing, revealing a new function of ADAR1 in the regulation of RNA interference.

MeSH Terms
Adenosine/metabolism Adenosine Deaminase/genetics,metabolism Alu Elements Animals Caenorhabditis elegans/genetics,metabolism Drosophila melanogaster/genetics,metabolism Genome Humans Inosine/metabolism Isoenzymes/genetics,metabolism MicroRNAs/genetics,metabolism RNA Editing RNA, Messenger/genetics,metabolism Ribonuclease III/genetics,metabolism Signal Transduction
Chemicals
Isoenzymes MicroRNAs RNA, Messenger Inosine Ribonuclease III Adenosine Deaminase Adenosine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nishikura Kazuko
The Wistar Institute, Department of Gene Expression and Regulation, 3601 Spruce Street, Philadelphia, Pennsylvania 19104-4268, USA.
References (146)
146 references, click to expand
  1. Inosine-containing dsRNA binds a stress-granule-like complex and downregulates gene expression in trans.
    Mol Cell. 2007 Nov 9;28(3):491-500 PMID: 17996712
  2. Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
    Nat Cell Biol. 2015 Mar;17(3):311-21 PMID: 25686251
  3. Adenosine-to-inosine RNA editing affects trafficking of the gamma-aminobutyric acid type A (GABA(A)) receptor.
    J Biol Chem. 2011 Jan 21;286(3):2031-40 PMID: 21030585
  4. MicroRNAs in stress signaling and human disease.
    Cell. 2012 Mar 16;148(6):1172-87 PMID: 22424228
  5. Functions and regulation of RNA editing by ADAR deaminases.
    Annu Rev Biochem. 2010;79:321-49 PMID: 20192758
  6. Adenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs.
    Genome Res. 2012 Aug;22(8):1468-76 PMID: 22310477
  7. Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviors.
    Neuropharmacology. 2010 Nov;59(6):468-73 PMID: 20624407
  8. The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.
    Cell Rep. 2014 Nov 20;9(4):1482-94 PMID: 25456137
  9. On the mechanism of induction of heterochromatin by the RNA-binding protein vigilin.
    RNA. 2008 Sep;14(9):1773-81 PMID: 18648073
  10. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2.
    Nature. 2000 Jul 6;406(6791):78-81 PMID: 10894545
  11. RED2, a brain-specific member of the RNA-specific adenosine deaminase family.
    J Biol Chem. 1996 Dec 13;271(50):31795-8 PMID: 8943218
  12. Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants.
    Science. 2003 Dec 5;302(5651):1725 PMID: 14657490
  13. Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.
    J Neurosci. 2008 Nov 26;28(48):12834-44 PMID: 19036977
  14. An unwinding activity that covalently modifies its double-stranded RNA substrate.
    Cell. 1988 Dec 23;55(6):1089-98 PMID: 3203381
  15. Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities.
    Biochemistry. 2000 Oct 24;39(42):12875-84 PMID: 11041852
  16. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
    Nat Med. 2013 Feb;19(2):209-16 PMID: 23291631
  17. Altered RNA editing in mice lacking ADAR2 autoregulation.
    Mol Cell Biol. 2006 Jan;26(2):480-8 PMID: 16382140
  18. Competition between ADAR and RNAi pathways for an extensive class of RNA targets.
    Nat Struct Mol Biol. 2011 Oct;18(10):1094-101 PMID: 21909095
  19. Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.
    Genome Biol. 2015;16:5 PMID: 25582055
  20. ADARs: viruses and innate immunity.
    Curr Top Microbiol Immunol. 2012;353:163-95 PMID: 21809195
  21. Glutamate receptors: RNA editing and death of motor neurons.
    Nature. 2004 Feb 26;427(6977):801 PMID: 14985749
  22. Systematic identification of edited microRNAs in the human brain.
    Genome Res. 2012 Aug;22(8):1533-40 PMID: 22499667
  23. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains.
    RNA. 2000 May;6(5):755-67 PMID: 10836796
  24. Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome.
    Nat Chem Biol. 2010 Oct;6(10):733-40 PMID: 20835228
  25. Control of kinetic properties of AMPA receptor channels by nuclear RNA editing.
    Science. 1994 Dec 9;266(5191):1709-13 PMID: 7992055
  26. A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.
    Gut. 2014 May;63(5):832-43 PMID: 23766440
  27. Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome.
    Neurobiol Dis. 2010 Aug;39(2):169-80 PMID: 20394819
  28. RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.
    Mol Cell Biol. 2009 Mar;29(6):1487-97 PMID: 19124606
  29. Nucleocytoplasmic distribution of human RNA-editing enzyme ADAR1 is modulated by double-stranded RNA-binding domains, a leucine-rich export signal, and a putative dimerization domain.
    Mol Biol Cell. 2002 Nov;13(11):3822-35 PMID: 12429827
  30. c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.
    PLoS One. 2012;7(11):e48611 PMID: 23139803
  31. The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
    Cancer Cell. 2015 Oct 12;28(4):515-28 PMID: 26439496
  32. Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin.
    Curr Biol. 2005 Feb 22;15(4):384-91 PMID: 15723802
  33. Human endonuclease V is a ribonuclease specific for inosine-containing RNA.
    Nat Commun. 2013;4:2273 PMID: 23912718
  34. A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes.
    Genome Res. 2014 Mar;24(3):365-76 PMID: 24347612
  35. Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6.
    Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):755-9 PMID: 7678465
  36. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.
    Genes Dev. 2010 May 15;24(10):992-1009 PMID: 20413612
  37. Double-stranded RNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis.
    Nat Struct Mol Biol. 2010 Sep;17(9):1043-50 PMID: 20694008
  38. Identification of microRNAs of the herpesvirus family.
    Nat Methods. 2005 Apr;2(4):269-76 PMID: 15782219
  39. RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1.
    Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20715-9 PMID: 21068368
  40. Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome.
    Nat Biotechnol. 2012 Mar;30(3):253-60 PMID: 22327324
  41. Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome.
    Cell Rep. 2015 Oct 13;13(2):277-89 PMID: 26440892
  42. A mammalian RNA editing enzyme.
    Nature. 1996 Feb 1;379(6564):460-4 PMID: 8559253
  43. Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.
    J Biol Chem. 2004 Feb 6;279(6):4952-61 PMID: 14613934
  44. Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules.
    Nucleic Acids Res. 2013 Nov;41(21):9786-99 PMID: 23982513
  45. Enrichment for histone H3 lysine 9 methylation at Alu repeats in human cells.
    J Biol Chem. 2003 Jul 25;278(30):27658-62 PMID: 12724318
  46. Functions and regulation of the APOBEC family of proteins.
    Semin Cell Dev Biol. 2012 May;23(3):258-68 PMID: 22001110
  47. A survey of RNA editing in human brain.
    Genome Res. 2004 Dec;14(12):2379-87 PMID: 15545495
  48. ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia.
    Neuron. 2006 Mar 2;49(5):719-33 PMID: 16504947
  49. Regulation of microRNA biogenesis.
    Nat Rev Mol Cell Biol. 2014 Aug;15(8):509-24 PMID: 25027649
  50. RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions.
    J Biol Chem. 2007 Jun 1;282(22):16054-61 PMID: 17428802
  51. Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects.
    EMBO J. 2011 Oct 19;30(20):4211-22 PMID: 21847096
  52. RNA-editing-mediated exon evolution.
    Genome Biol. 2007;8(2):R29 PMID: 17326827
  53. ADAR mediates differential expression of polycistronic microRNAs.
    Nucleic Acids Res. 2014 Apr;42(8):5245-55 PMID: 24561617
  54. Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.
    Nat Genet. 2012 Nov;44(11):1243-8 PMID: 23001123
  55. Origins and evolution of ADAR-mediated RNA editing.
    IUBMB Life. 2009 Jun;61(6):572-8 PMID: 19472181
  56. ADARs and the Balance Game between Virus Infection and Innate Immune Cell Response.
    Curr Issues Mol Biol. 2015;17:37-51 PMID: 25502818
  57. Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways.
    Nat Commun. 2015;6:6355 PMID: 25751603
  58. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing.
    Cell. 2013 Apr 25;153(3):575-89 PMID: 23622242
  59. A-to-I editing of microRNAs in the mammalian brain increases during development.
    Genome Res. 2012 Aug;22(8):1477-87 PMID: 22645261
  60. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs.
    Science. 2007 Feb 23;315(5815):1137-40 PMID: 17322061
  61. Generation and analysis of GluR5(Q636R) kainate receptor mutant mice.
    J Neurosci. 1999 Oct 15;19(20):8757-64 PMID: 10516295
  62. Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation.
    J Neurosci. 2007 Jul 25;27(30):7987-8001 PMID: 17652589
  63. RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.
    Science. 2015 Sep 4;349(6252):1115-20 PMID: 26275108
  64. Control of human potassium channel inactivation by editing of a small mRNA hairpin.
    Nat Struct Mol Biol. 2004 Oct;11(10):950-6 PMID: 15361858
  65. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.
    Nat Immunol. 2009 Jan;10(1):109-15 PMID: 19060901
  66. Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome.
    PLoS Biol. 2004 Dec;2(12):e391 PMID: 15534692
  67. RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex.
    EMBO Rep. 2007 Aug;8(8):763-9 PMID: 17599088
  68. Autoinhibition of human dicer by its internal helicase domain.
    J Mol Biol. 2008 Jun 27;380(1):237-43 PMID: 18508075
  69. Modulation of RNA editing by functional nucleolar sequestration of ADAR2.
    Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14018-23 PMID: 14612560
  70. The importance of internal loops within RNA substrates of ADAR1.
    J Mol Biol. 1999 Aug 6;291(1):1-13 PMID: 10438602
  71. RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans.
    EMBO J. 2002 Nov 15;21(22):6025-35 PMID: 12426375
  72. Accurate identification of human Alu and non-Alu RNA editing sites.
    Nat Methods. 2012 Jun;9(6):579-81 PMID: 22484847
  73. A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase.
    Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8421-6 PMID: 9237992
  74. RNA editing in plants and its evolution.
    Annu Rev Genet. 2013;47:335-52 PMID: 24274753
  75. Editing independent effects of ADARs on the miRNA/siRNA pathways.
    EMBO J. 2009 Oct 21;28(20):3145-56 PMID: 19713932
  76. A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.
    Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1852-61 PMID: 24753571
  77. Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing.
    Science. 2009 May 29;324(5931):1210-3 PMID: 19478186
  78. Regulation of serotonin-2C receptor G-protein coupling by RNA editing.
    Nature. 1997 May 15;387(6630):303-8 PMID: 9153397
  79. Modulation of microRNA processing and expression through RNA editing by ADAR deaminases.
    Nat Struct Mol Biol. 2006 Jan;13(1):13-21 PMID: 16369484
  80. RNA editing of androgen receptor gene transcripts in prostate cancer cells.
    J Biol Chem. 2008 Oct 31;283(44):29938-49 PMID: 18708348
  81. A developmentally regulated activity that unwinds RNA duplexes.
    Cell. 1987 Feb 27;48(4):607-13 PMID: 2434241
  82. Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1.
    J Biol Chem. 2004 Feb 6;279(6):4894-902 PMID: 14615479
  83. Frequency and fate of microRNA editing in human brain.
    Nucleic Acids Res. 2008 Sep;36(16):5270-80 PMID: 18684997
  84. Editor meets silencer: crosstalk between RNA editing and RNA interference.
    Nat Rev Mol Cell Biol. 2006 Dec;7(12):919-31 PMID: 17139332
  85. RNA editing in RHOQ promotes invasion potential in colorectal cancer.
    J Exp Med. 2014 Apr 7;211(4):613-21 PMID: 24663214
  86. CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain.
    Mol Cell Biol. 2001 Nov;21(22):7862-71 PMID: 11604520
  87. Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.
    Cell Rep. 2015 Oct 13;13(2):267-76 PMID: 26440895
  88. Transcript diversification in the nervous system: a to I RNA editing in CNS function and disease development.
    Front Neurosci. 2012 Jul 09;6:99 PMID: 22787438
  89. Substrate specificity of the dsRNA unwinding/modifying activity.
    EMBO J. 1991 Nov;10(11):3523-32 PMID: 1915306
  90. Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.
    J Immunol. 2014 Oct 1;193(7):3436-45 PMID: 25172485
  91. ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers.
    PLoS One. 2013;8(12):e81922 PMID: 24386085
  92. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
    Cell. 1991 Oct 4;67(1):11-9 PMID: 1717158
  93. RNA editing by mammalian ADARs.
    Adv Genet. 2011;73:87-120 PMID: 21310295
  94. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
    Science. 2005 Sep 2;309(5740):1534-9 PMID: 16141067
  95. Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency.
    J Biol Chem. 2010 Oct 22;285(43):33358-70 PMID: 20716523
  96. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
    BMC Dev Biol. 2005;5:14 PMID: 16033648
  97. Functions and mechanisms of RNA editing.
    Annu Rev Genet. 2000;34:499-531 PMID: 11092837
  98. The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.
    Cell. 2001 Aug 24;106(4):465-75 PMID: 11525732
  99. Widespread RNA editing of embedded alu elements in the human transcriptome.
    Genome Res. 2004 Sep;14(9):1719-25 PMID: 15342557
  100. ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner.
    Cell Res. 2015 Apr;25(4):459-76 PMID: 25708366
  101. Systematic identification of abundant A-to-I editing sites in the human transcriptome.
    Nat Biotechnol. 2004 Aug;22(8):1001-5 PMID: 15258596
  102. RNA editing in regulating gene expression in the brain.
    Biochim Biophys Acta. 2008 Aug;1779(8):459-70 PMID: 18086576
  103. Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.
    Mol Cell Biol. 1995 Oct;15(10):5376-88 PMID: 7565688
  104. Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA.
    Mol Cell. 2009 Aug 28;35(4):467-78 PMID: 19716791
  105. Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain.
    RNA. 2006 Jul;12(7):1350-60 PMID: 16682559
  106. The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage.
    Nat Struct Mol Biol. 2005 Jun;12(6):489-96 PMID: 15895094
  107. A-to-I RNA editing: the "ADAR" side of human cancer.
    Semin Cell Dev Biol. 2012 May;23(3):244-50 PMID: 21930228
  108. Adenosine-to-inosine RNA editing and human disease.
    Genome Med. 2013 Nov 29;5(11):105 PMID: 24289319
  109. Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA.
    J Biol Chem. 2003 May 9;278(19):17093-102 PMID: 12618436
  110. The emerging role of RNA editing in plasticity.
    J Exp Biol. 2015 Jun;218(Pt 12):1812-21 PMID: 26085659
  111. RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling.
    RNA Biol. 2013 Feb;10(2):321-33 PMID: 23324600
  112. RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency.
    Cell. 1993 Dec 31;75(7):1361-70 PMID: 8269514
  113. A genome-wide map of hyper-edited RNA reveals numerous new sites.
    Nat Commun. 2014;5:4726 PMID: 25158696
  114. Structure and specific RNA binding of ADAR2 double-stranded RNA binding motifs.
    Structure. 2006 Feb;14(2):345-55 PMID: 16472753
  115. Evolutionarily conserved human targets of adenosine to inosine RNA editing.
    Nucleic Acids Res. 2005;33(4):1162-8 PMID: 15731336
  116. A-to-I RNA editing: effects on proteins key to neural excitability.
    Neuron. 2012 May 10;74(3):432-9 PMID: 22578495
  117. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.
    Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17763-8 PMID: 19805087
  118. Double-stranded RNA as a template for gene silencing.
    Cell. 2000 Apr 28;101(3):235-8 PMID: 10847677
  119. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.
    Nat Rev Genet. 2013 Feb;14(2):100-12 PMID: 23329111
  120. Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.
    Curr Top Microbiol Immunol. 2012;353:61-90 PMID: 21796513
  121. Regulating gene expression through RNA nuclear retention.
    Cell. 2005 Oct 21;123(2):249-63 PMID: 16239143
  122. Regulation of alternative splicing by RNA editing.
    Nature. 1999 May 6;399(6731):75-80 PMID: 10331393
  123. Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells.
    J Clin Invest. 2012 Nov;122(11):4059-76 PMID: 23093778
  124. Identification of a selective nuclear import signal in adenosine deaminases acting on RNA.
    Nucleic Acids Res. 2009 Sep;37(17):5822-9 PMID: 19617375
  125. Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2.
    J Neurosci. 2010 Sep 8;30(36):11917-25 PMID: 20826656
  126. Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse.
    Biol Reprod. 1995 Jun;52(6):1274-83 PMID: 7543294
  127. Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.
    Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11457-61 PMID: 7972084
  128. A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme.
    Oncotarget. 2015 Oct 6;6(30):28999-9015 PMID: 26338962
  129. Comparative RNA editing in autistic and neurotypical cerebella.
    Mol Psychiatry. 2013 Sep;18(9):1041-8 PMID: 22869036
  130. miRNAs, cancer, and stem cell division.
    Cell. 2005 Jul 15;122(1):6-7 PMID: 16009126
  131. Ten novel mutations of the ADAR1 gene in Japanese patients with dyschromatosis symmetrica hereditaria.
    J Invest Dermatol. 2007 Feb;127(2):309-11 PMID: 16917490
  132. RNA editing regulates transposon-mediated heterochromatic gene silencing.
    Nat Commun. 2013;4:2745 PMID: 24201902
  133. Human BLCAP transcript: new editing events in normal and cancerous tissues.
    Int J Cancer. 2010 Jul 1;127(1):127-37 PMID: 19908260
  134. Alu element-mediated gene silencing.
    EMBO J. 2008 Jun 18;27(12):1694-705 PMID: 18497743
  135. Identifying RNA editing sites using RNA sequencing data alone.
    Nat Methods. 2013 Feb;10(2):128-32 PMID: 23291724
  136. Tudor-SN and ADAR1 are components of cytoplasmic stress granules.
    RNA. 2012 Mar;18(3):462-71 PMID: 22240577
  137. Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible.
    Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4621-6 PMID: 10200312
  138. Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing.
    J Gen Virol. 2013 Dec;94(Pt 12):2739-44 PMID: 24045110
  139. Effects of ADARs on small RNA processing pathways in C. elegans.
    Genome Res. 2012 Aug;22(8):1488-98 PMID: 22673872
  140. Dynamic association of RNA-editing enzymes with the nucleolus.
    J Cell Sci. 2003 May 1;116(Pt 9):1805-18 PMID: 12665561
  141. Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans.
    Nucleic Acids Res. 2014 Jun;42(10):e87 PMID: 24744243
  142. Specific cleavage of hyper-edited dsRNAs.
    EMBO J. 2001 Aug 1;20(15):4243-52 PMID: 11483527
  143. Mitochondrial RNA processing in trypanosomes.
    Res Microbiol. 2011 Sep;162(7):655-63 PMID: 21596134
  144. A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs.
    Proc Natl Acad Sci U S A. 1989 Apr;86(8):2647-51 PMID: 2704740
  145. Antagonistic and stimulative roles of ADAR1 in RNA silencing.
    RNA Biol. 2013 Aug;10(8):1240-7 PMID: 23949595
  146. Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing.
    Neuron. 1993 Mar;10(3):491-500 PMID: 7681676
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm.2015.4
Published
2016-02-00
Epub
2015-00-09
Pages
83-96
Language
English
Region
England
NLM ID
100962782
PMCID
PMC4824625
Subset
IM
Grants
NCI NIH HHS · P30 CA010815 · United States
NCI NIH HHS · R01 CA175058 · United States
NIGMS NIH HHS · R01 GM040536 · United States
External Links
PubMed source DOI: 10.1038/nrm.2015.4 PMC Full Text View journal details
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