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PMID: 8388099 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Identification of a new, abundant superfamily of mammalian LTR-transposons.

Nucleic acids research ·Vol. 21 ·No. 8 ·1993-04-25 ·Pages 1863-72

Smit AF

Abstract

A new superfamily of mammalian transposable genetic elements is described with an estimated 40,000 to 100,000 members in both primate and rodent genomes. Sequences known before as MT, ORR-1, MstII, MER15 and MER18 are shown to represent (part of) the long terminal repeats of retrotransposon-like elements related to THE1 in humans. These transposons have structural similarities to retroviruses. However, the putative product of a 1350 base pair open reading frame detected in the consensus internal sequence of THE1 does not resemble retroviral proteins. The elements are named 'Mammalian apparent LTR-retrotransposons' (MaLRs). The internal sequence is usually found to be excised. Their presence in rodents, artiodactyls, lagomorphs, and primates, the divergence of the individual elements from their consensus, and the existence of a probably orthologous element in mouse and man suggest that the first MaLRs were distributed before the radiation of eutherian mammals 80-100 million years ago. MaLRs may prove to be very helpful in determining the evolutionary branching pattern of mammalian orders and suborders.

MeSH Terms
Animals Base Sequence Biological Evolution Cricetinae DNA DNA Transposable Elements Humans Mammals/genetics Molecular Sequence Data Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid
Chemicals
DNA Transposable Elements DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Smit A F
Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010-0269.
References (55)
55 references, click to expand
  1. Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing.
    Nature. 1982 Mar 25;296(5855):321-5 PMID: 6801526
  2. Cloning and characterization of the rat NADPH-cytochrome P-450 oxidoreductase gene.
    J Biol Chem. 1983 Jan 25;258(2):1363-8 PMID: 6296077
  3. Rapid similarity searches of nucleic acid and protein data banks.
    Proc Natl Acad Sci U S A. 1983 Feb;80(3):726-30 PMID: 6572363
  4. Unusual sequences in the murine immunoglobulin mu-delta heavy-chain region.
    Nature. 1983 Dec 1-7;306(5942):483-7 PMID: 6417547
  5. Non-Alu family interspersed repeats in human DNA and their transcriptional activity.
    Nucleic Acids Res. 1984 Mar 26;12(6):2669-90 PMID: 6546796
  6. The sequence of the human immunoglobulin mu-delta intron reveals possible vestigial switch segments.
    Nucleic Acids Res. 1984 Aug 24;12(16):6523-35 PMID: 6089118
  7. Transcription termination and 3' processing: the end is in site!
    Cell. 1985 Jun;41(2):349-59 PMID: 2580642
  8. Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
    Nucleic Acids Res. 1985 Jun 25;13(12):4503-20 PMID: 2989797
  9. A transposon-like element in human DNA.
    Nature. 1985 Jul 25-31;316(6026):359-61 PMID: 2862587
  10. The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene.
    Nucleic Acids Res. 1985 Oct 25;13(20):7515-28 PMID: 2997750
  11. A multiple sequence alignment program.
    Nucleic Acids Res. 1986 Jan 10;14(1):363-74 PMID: 3753772
  12. Insertion and/or deletion of many repeated DNA sequences in human and higher ape evolution.
    Proc Natl Acad Sci U S A. 1986 Jun;83(11):3875-9 PMID: 3012536
  13. Molecular characterization of the MT-family of dispersed middle-repetitive DNA in rodent genomes.
    Nucleic Acids Res. 1986 Aug 26;14(16):6403-16 PMID: 3755820
  14. A family of short, interspersed repeats is associated with tandemly repetitive DNA in the human genome.
    Proc Natl Acad Sci U S A. 1987 May;84(10):3320-4 PMID: 3554237
  15. Transcription of a human transposon-like sequence is usually directed by other promoters.
    Nucleic Acids Res. 1987 Jul 10;15(13):5199-215 PMID: 3037490
  16. Molecular analysis of a constitutional X-autosome translocation in a female with muscular dystrophy.
    Science. 1987 Sep 25;237(4822):1620-4 PMID: 3629260
  17. An evaluation of the molecular clock hypothesis using mammalian DNA sequences.
    J Mol Evol. 1987;25(4):330-42 PMID: 3118047
  18. The MT family of mouse DNA is made of short interspersed repeated elements.
    Gene. 1987;57(1):81-8 PMID: 3428613
  19. Human transposon-like elements insert at a preferred target site: evidence for a retrovirally mediated process.
    Nucleic Acids Res. 1988 Feb 11;16(3):1143-51 PMID: 2830591
  20. Phylogenetic screening of the human genome: identification of differentially hybridizing repetitive sequence families.
    Mol Biol Evol. 1987 Mar;4(2):85-98 PMID: 2833668
  21. Molecular analysis of human repetitive sequence family and its use as genetic marker.
    Somat Cell Mol Genet. 1987 Jul;13(4):381-9 PMID: 2842877
  22. Sigma region located between C mu and C delta genes of human immunoglobulin heavy chain: possible involvement of tRNA-like structure in RNA splicing.
    Nucleic Acids Res. 1988 Oct 25;16(20):9497-511 PMID: 3141902
  23. Origins and evolutionary relationships of retroviruses.
    Q Rev Biol. 1989 Mar;64(1):1-30 PMID: 2469098
  24. Reverse transcriptases. Retrons in bacteria.
    Nature. 1989 May 25;339(6222):254-5 PMID: 2471077
  25. The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
    DNA. 1989 Sep;8(7):503-16 PMID: 2766932
  26. A nuclear protein associated with human cancer cells binds preferentially to a human repetitive DNA sequence.
    Proc Natl Acad Sci U S A. 1989 Nov;86(21):8472-6 PMID: 2813405
  27. Newly arisen DNA repeats in primate phylogeny.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9360-4 PMID: 2480599
  28. Intramolecular DNA triplexes, bent DNA and DNA unwinding elements in the initiation region of an amplified dihydrofolate reductase replicon.
    J Mol Biol. 1990 Jan 5;211(1):19-33 PMID: 2299670
  29. Novel families of interspersed repetitive elements from the human genome.
    Nucleic Acids Res. 1990 Jan 11;18(1):137-41 PMID: 2106661
  30. Endogenous retroviral elements in human DNA.
    Cancer Res. 1990 Sep 1;50(17 Suppl):5636S-5642S PMID: 2167160
  31. Human sex-chromosome-specific repeats within a region of pseudoautosomal/Yq homology.
    Genomics. 1990 Aug;7(4):625-8 PMID: 2387589
  32. Integration of retroviral DNA.
    Curr Top Microbiol Immunol. 1990;157:19-48 PMID: 2203610
  33. Molecular phylogeny of Rodentia, Lagomorpha, Primates, Artiodactyla, and Carnivora and molecular clocks.
    Proc Natl Acad Sci U S A. 1990 Sep;87(17):6703-7 PMID: 2395871
  34. Origin and evolution of retroelements based upon their reverse transcriptase sequences.
    EMBO J. 1990 Oct;9(10):3353-62 PMID: 1698615
  35. Single copy sequences in galago DNA resemble a repetitive human retrotransposon-like family.
    J Mol Evol. 1990 Aug;31(2):92-100 PMID: 2170666
  36. Amplification of an ancestral mammalian L1 family of long interspersed repeated DNA occurred just before the murine radiation.
    Proc Natl Acad Sci U S A. 1990 Dec;87(23):9481-5 PMID: 2251288
  37. Sequence identification of 2,375 human brain genes.
    Nature. 1992 Feb 13;355(6361):632-4 PMID: 1538749
  38. Demonstration of retrotransposition of the Tf1 element in fission yeast.
    EMBO J. 1992 Mar;11(3):1145-53 PMID: 1312461
  39. Master genes in mammalian repetitive DNA amplification.
    Trends Genet. 1992 Sep;8(9):307-11 PMID: 1365396
  40. The human immunoglobulin C mu-C delta locus: complete nucleotide sequence and structural analysis.
    Int Immunol. 1989;1(3):296-309 PMID: 2518659
  41. Mouse retrotransposons: a cellular reservoir of long terminal repeat (LTR) elements with diverse transcriptional specificities.
    Adv Cancer Res. 1991;56:215-51 PMID: 1851374
  42. The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein.
    Mol Cell Biol. 1991 Jun;11(6):3317-25 PMID: 2038334
  43. Molecular evolution of the psi eta-globin gene locus: gibbon phylogeny and the hominoid slowdown.
    Mol Biol Evol. 1991 Mar;8(2):155-84 PMID: 2046542
  44. Synonymous nucleotide substitution rates in mammalian genes: implications for the molecular clock and the relationship of mammalian orders.
    Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5974-8 PMID: 2068073
  45. Medium reiteration frequency repetitive sequences in the human genome.
    Nucleic Acids Res. 1991 Sep 11;19(17):4731-8 PMID: 1891362
  46. Evolution of retroposons by acquisition or deletion of retrovirus-like genes.
    Mol Biol Evol. 1991 Nov;8(6):835-56 PMID: 1663570
  47. The human THE-LTR(O) and MstII interspersed repeats are subfamilies of a single widely distributed highly variable repeat family.
    Genomics. 1992 Jun;13(2):431-6 PMID: 1319393
  48. Cloning of a mu-class glutathione S-transferase gene and identification of the glucocorticoid regulatory domains in its 5' flanking sequence.
    Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6104-8 PMID: 1631097
  49. SINEs.
    Curr Opin Genet Dev. 1991 Dec;1(4):498-504 PMID: 1668310
  50. LINEs.
    Curr Opin Genet Dev. 1991 Dec;1(4):505-8 PMID: 1726579
  51. The beta globin gene cluster of the prosimian primate Galago crassicaudatus: nucleotide sequence determination of the 41-kb cluster and comparative sequence analyses.
    Genomics. 1992 Jul;13(3):741-60 PMID: 1639402
  52. A mammalian molecular clock?
    Bioessays. 1992 Jun;14(6):415-9 PMID: 1503557
  53. Structure and organization of the human S-adenosylmethionine decarboxylase gene.
    J Biol Chem. 1992 Sep 15;267(26):18915-23 PMID: 1527020
  54. The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis.
    Cell. 1992 Nov 13;71(4):663-70 PMID: 1384989
  55. The molecular clock ticks regularly in muroid rodents and hamsters.
    J Mol Evol. 1992 Nov;35(5):377-84 PMID: 1487823
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/21.8.1863
Published
1993-04-25
Pages
1863-72
Language
English
Region
England
NLM ID
0411011
PMCID
PMC309426
Subset
IM
Grants
NIA NIH HHS · AG08196 · United States
External Links
PubMed source DOI: 10.1093/nar/21.8.1863 PMC Full Text View journal details
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