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PMID: 21984887 Published · ppublish English Journal Article

Membrane elongation factors in organelle maintenance: the case of peroxisome proliferation.

Biomolecular concepts ·Vol. 2 ·No. 5 ·2011-10-00 ·Pages 353-364

Koch J, Brocard C

Abstract

Separation of metabolic pathways in organelles is critical for eukaryotic life. Accordingly, the number, morphology and function of organelles have to be maintained through processes linked with membrane remodeling events. Despite their acknowledged significance and intense study many questions remain about the molecular mechanisms by which organellar membranes proliferate. Here, using the example of peroxisome proliferation, we give an overview of how proteins elongate membranes. Subsequent membrane fission is achieved by dynamin-related proteins shared with mitochondria. We discuss basic criteria that membranes have to fulfill for these fission factors to complete the scission. Because peroxisome elongation is always associated with unequal distribution of matrix and membrane proteins, we propose peroxisomal division to be non-stochastic and asymmetric. We further show that these organelles need not be functional to carry on membrane elongation and present the most recent findings concerning members of the Pex11 protein family as membrane elongation factors. These factors, beside known proteins such as BAR-domain proteins, represent another family of proteins containing an amphipathic α-helix with membrane bending activity.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Koch Johannes
Department of Biochemistry and Cell Biology, University of Vienna, Max F. Perutz Laboratories, Center of Molecular Biology, Dr. Bohr-Gasse 9, A-1030 Vienna, Austria.
Brocard Cécile
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Article Info
Journal
Biomolecular concepts
Abbr.
Biomol Concepts
ISSN
1868-503X
DOI
10.1515/BMC.2011.031
Published
2011-10-00
Pages
353-364
Language
English
Region
Germany
NLM ID
101518829
PMCID
PMC3186938
Grants
Austrian Science Fund FWF · P 20803 · Austria
Austrian Science Fund FWF · V 39 · Austria
External Links
PubMed source DOI: 10.1515/BMC.2011.031 PMC Full Text View journal details
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