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PMID: 17604854 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.

Biochimica et biophysica acta ·Vol. 1773 ·No. 8 ·2007-08-00 ·Pages 1311-40

Chen RE, Thorner J

Abstract

Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit many of the responses that are evoked in cells by changes in certain environmental conditions and upon exposure to a variety of hormonal and other stimuli. These pathways were first elucidated in the unicellular eukaryote Saccharomyces cerevisiae (budding yeast). Studies of MAPK pathways in this organism continue to be especially informative in revealing the molecular mechanisms by which MAPK cascades operate, propagate signals, modulate cellular processes, and are controlled by regulatory factors both internal to and external to the pathways. Here we highlight recent advances and new insights about MAPK-based signaling that have been made through studies in yeast, which provide lessons directly applicable to, and that enhance our understanding of, MAPK-mediated signaling in mammalian cells.

MeSH Terms
Cell Cycle Enzyme Activation MAP Kinase Signaling System/physiology Models, Biological Protein Biosynthesis Saccharomyces cerevisiae/cytology,genetics,growth & development,metabolism Transcription, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chen Raymond E
Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.
Thorner Jeremy
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbamcr.2007.05.003
Published
2007-08-00
Epub
2007-00-22
Pages
1311-40
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC2031910
Subset
IM
Grants
NIGMS NIH HHS · R01 GM021841 · United States
NIGMS NIH HHS · R01 GM021841-33 · United States
NIGMS NIH HHS · T32 GM007232 · United States
NIGMS NIH HHS · GM07232 · United States
NIGMS NIH HHS · GM21841 · United States
External Links
PubMed source DOI: 10.1016/j.bbamcr.2007.05.003 PMC Full Text
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