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PMID: 8464403 Published · ppublish English Journal Article Review

Protein secretion in Bacillus species.

Microbiological reviews ·Vol. 57 ·No. 1 ·1993-03-00 ·Pages 109-37

Simonen M, Palva I

Abstract

Bacilli secrete numerous proteins into the environment. Many of the secretory proteins, their export signals, and their processing steps during secretion have been characterized in detail. In contrast, the molecular mechanisms of protein secretion have been relatively poorly characterized. However, several components of the protein secretion machinery have been identified and cloned recently, which is likely to lead to rapid expansion of the knowledge of the protein secretion mechanism in Bacillus species. Comparison of the presently known export components of Bacillus species with those of Escherichia coli suggests that the mechanism of protein translocation across the cytoplasmic membrane is conserved among gram-negative and gram-positive bacteria differences are found in steps preceding and following the translocation process. Many of the secretory proteins of bacilli are produced industrially, but several problems have been encountered in the production of Bacillus heterologous secretory proteins. In the final section we discuss these problems and point out some possibilities to overcome them.

MeSH Terms
Amino Acid Sequence Bacillus/metabolism Bacterial Proteins/biosynthesis Biological Transport/physiology Molecular Sequence Data Protein Sorting Signals/chemistry,metabolism
Chemicals
Bacterial Proteins Protein Sorting Signals
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Simonen M
Institute of Biotechnology, University of Helsinki, Finland.
Palva I
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Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.57.1.109-137.1993
Published
1993-03-00
Pages
109-37
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC372902
Subset
IM
External Links
PubMed source DOI: 10.1128/mr.57.1.109-137.1993 PMC Full Text
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