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PMID: 17220175 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Ubiquitin, hormones and biotic stress in plants.

Annals of botany ·Vol. 99 ·No. 5 ·2007-05-00 ·Pages 787-822

Dreher K, Callis J

Abstract

The covalent attachment of ubiquitin to a substrate protein changes its fate. Notably, proteins typically tagged with a lysine48-linked polyubiquitin chain become substrates for degradation by the 26S proteasome. In recent years many experiments have been performed to characterize the proteins involved in the ubiquitylation process and to identify their substrates, in order to understand better the mechanisms that link specific protein degradation events to regulation of plant growth and development. This review focuses on the role that ubiquitin plays in hormone synthesis, hormonal signalling cascades and plant defence mechanisms. Several examples are given of how targeted degradation of proteins affects downstream transcriptional regulation of hormone-responsive genes in the auxin, gibberellin, abscisic acid, ethylene and jasmonate signalling pathways. Additional experiments suggest that ubiquitin-mediated proteolysis may also act upstream of the hormonal signalling cascades by regulating hormone biosynthesis, transport and perception. Moreover, several experiments demonstrate that hormonal cross-talk can occur at the level of proteolysis. The more recently established role of the ubiquitin/proteasome system (UPS) in defence against biotic threats is also reviewed. The UPS has been implicated in the regulation of almost every developmental process in plants, from embryogenesis to floral organ production probably through its central role in many hormone pathways. More recent evidence provides molecular mechanisms for hormonal cross-talk and links the UPS system to biotic defence responses.

MeSH Terms
Plant Growth Regulators/metabolism Plant Proteins/metabolism Plants/embryology,metabolism Proteasome Endopeptidase Complex/metabolism Ubiquitin/metabolism
Chemicals
Plant Growth Regulators Plant Proteins Ubiquitin Proteasome Endopeptidase Complex
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dreher Kate
Section of Molecular and Cellular Biology, Plant Biology Graduate Group Program, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA. [email protected]
Callis Judy
References (343)
343 references, click to expand
  1. Profiling ethylene-regulated gene expression in Arabidopsis thaliana by microarray analysis.
    Plant Mol Biol. 2003 Sep;53(1-2):117-31 PMID: 14756311
  2. The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.
    Dev Cell. 2003 May;4(5):699-710 PMID: 12737805
  3. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.
    Mol Cell. 2006 May 5;22(3):383-94 PMID: 16678110
  4. The AIP2 E3 ligase acts as a novel negative regulator of ABA signaling by promoting ABI3 degradation.
    Genes Dev. 2005 Jul 1;19(13):1532-43 PMID: 15998807
  5. RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis.
    Cell. 2002 Mar 22;108(6):743-54 PMID: 11955429
  6. The armadillo family of structural proteins.
    Int Rev Cytol. 1999;186:179-224 PMID: 9770300
  7. In planta protein-protein interactions assessed using a nanovirus-based replication and expression system.
    Plant J. 2002 Sep;31(6):767-75 PMID: 12220267
  8. Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4.
    Cell. 2003 Feb 7;112(3):369-77 PMID: 12581526
  9. Characterisation of BRH1, a brassinosteroid-responsive RING-H2 gene from Arabidopsis thaliana.
    Planta. 2002 May;215(1):127-33 PMID: 12012249
  10. Ethylene signal transduction.
    Ann Bot. 2005 May;95(6):901-15 PMID: 15753119
  11. CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.
    Genes Dev. 2006 Jun 1;20(11):1429-34 PMID: 16751180
  12. Protection of cullin-RING E3 ligases by CSN-UBP12.
    Trends Cell Biol. 2006 Jul;16(7):362-9 PMID: 16762551
  13. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
    Mol Cell Biol. 2005 Jan;25(1):162-71 PMID: 15601839
  14. A recessive mutation in the RUB1-conjugating enzyme, RCE1, reveals a requirement for RUB modification for control of ethylene biosynthesis and proper induction of basic chitinase and PDF1.2 in Arabidopsis.
    Plant J. 2004 May;38(4):626-38 PMID: 15125769
  15. Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules.
    EMBO J. 2006 Apr 19;25(8):1635-45 PMID: 16601694
  16. Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor.
    Cell. 2003 Dec 12;115(6):667-77 PMID: 14675532
  17. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.
    Cell. 1999 Mar 5;96(5):645-53 PMID: 10089880
  18. Intracellular trafficking and proteolysis of the Arabidopsis auxin-efflux facilitator PIN2 are involved in root gravitropism.
    Nat Cell Biol. 2006 Mar;8(3):249-56 PMID: 16489343
  19. The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex.
    J Cell Biol. 1999 May 31;145(5):933-50 PMID: 10352012
  20. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
    Cell. 1996 Jul 26;86(2):263-74 PMID: 8706131
  21. U box proteins as a new family of ubiquitin-protein ligases.
    J Biol Chem. 2001 Aug 31;276(35):33111-20 PMID: 11435423
  22. Auxin modulates the degradation rate of Aux/IAA proteins.
    Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11795-800 PMID: 11573012
  23. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response.
    Science. 2001 May 18;292(5520):1379-82 PMID: 11337587
  24. Loss-of-function mutations in chitin responsive genes show increased susceptibility to the powdery mildew pathogen Erysiphe cichoracearum.
    Plant Physiol. 2005 Jun;138(2):1027-36 PMID: 15923325
  25. Fold prediction and evolutionary analysis of the POZ domain: structural and evolutionary relationship with the potassium channel tetramerization domain.
    J Mol Biol. 1999 Jan 29;285(4):1353-61 PMID: 9917379
  26. The ubiquitin-activating enzyme (E1) gene family in Arabidopsis thaliana.
    Plant J. 1997 Feb;11(2):213-26 PMID: 9076989
  27. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.
    Mol Cell Biol. 1994 Aug;14(8):5501-9 PMID: 8035826
  28. Stability in vitro of the 69K movement protein of Turnip yellow mosaic virus is regulated by the ubiquitin-mediated proteasome pathway.
    J Gen Virol. 2002 Dec;83(Pt 12):3187-97 PMID: 12466497
  29. The jasmonate signal pathway.
    Plant Cell. 2002;14 Suppl:S153-64 PMID: 12045275
  30. Evidence for phosphorylation and ubiquitinylation of the turnip yellow mosaic virus RNA-dependent RNA polymerase domain expressed in a baculovirus-insect cell system.
    Biochem J. 2000 Jul 15;349(Pt 2):417-25 PMID: 10880340
  31. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p.
    BMC Biochem. 2001;2:7 PMID: 11504566
  32. Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
    Cell. 2006 Jan 13;124(1):105-17 PMID: 16413485
  33. Systemic acquired resistance.
    Annu Rev Phytopathol. 2004;42:185-209 PMID: 15283665
  34. DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.
    DNA Repair (Amst). 2005 May 2;4(5):537-45 PMID: 15811626
  35. Cryptogein affects expression of alpha3, alpha6 and beta1 20S proteasome subunits encoding genes in tobacco.
    J Exp Bot. 2001 Sep;52(362):1947-8 PMID: 11520884
  36. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.
    Mol Cell Biol. 2000 Apr;20(7):2326-33 PMID: 10713156
  37. TIP120A associates with cullins and modulates ubiquitin ligase activity.
    J Biol Chem. 2003 May 2;278(18):15905-10 PMID: 12609982
  38. Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins.
    Nature. 2001 Nov 15;414(6861):271-6 PMID: 11713520
  39. An Arabidopsis homologue of human seven-in-absentia-interacting protein is involved in pathogen resistance.
    Mol Cells. 2006 Jun 30;21(3):389-94 PMID: 16819302
  40. Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation.
    Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6803-8 PMID: 15090654
  41. Differential regulation of EIN3 stability by glucose and ethylene signalling in plants.
    Nature. 2003 Oct 2;425(6957):521-5 PMID: 14523448
  42. Arabidopsis Mutants Selected for Resistance to the Phytotoxin Coronatine Are Male Sterile, Insensitive to Methyl Jasmonate, and Resistant to a Bacterial Pathogen.
    Plant Cell. 1994 May;6(5):751-759 PMID: 12244256
  43. From the cradle to the grave: molecular chaperones that may choose between folding and degradation.
    EMBO Rep. 2001 Oct;2(10):885-90 PMID: 11600451
  44. The tobacco ubiquitin-activating enzymes NtE1A and NtE1B are induced by tobacco mosaic virus, wounding and stress hormones.
    Mol Cells. 2005 Apr 30;19(2):228-31 PMID: 15879707
  45. Mutations in an auxin receptor homolog AFB5 and in SGT1b confer resistance to synthetic picolinate auxins and not to 2,4-dichlorophenoxyacetic acid or indole-3-acetic acid in Arabidopsis.
    Plant Physiol. 2006 Oct;142(2):542-52 PMID: 16920877
  46. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
    Mol Cell. 2001 May;7(5):915-26 PMID: 11389839
  47. Flowering of the grass Lolium perenne: effects of vernalization and long days on gibberellin biosynthesis and signaling.
    Plant Physiol. 2005 Jul;138(3):1794-806 PMID: 15980191
  48. TIP120A associates with unneddylated cullin 1 and regulates its neddylation.
    FEBS Lett. 2003 Apr 24;541(1-3):102-8 PMID: 12706828
  49. Acceleration of Aux/IAA proteolysis is specific for auxin and independent of AXR1.
    Plant J. 2003 Aug;35(3):285-94 PMID: 12887580
  50. Phytochrome E controls light-induced germination of Arabidopsis.
    Plant Physiol. 2002 Jan;128(1):194-200 PMID: 11788765
  51. A DELLAcate balance: the role of gibberellin in plant morphogenesis.
    Curr Opin Plant Biol. 2005 Feb;8(1):77-85 PMID: 15653404
  52. Identification and characterization of Arabidopsis gibberellin receptors.
    Plant J. 2006 Jun;46(5):880-9 PMID: 16709201
  53. Isolation of tobacco ubiquitin-conjugating enzyme cDNA in a yeast two-hybrid system with tobacco ERF3 as bait and its characterization of specific interaction.
    J Exp Bot. 2003 Apr;54(385):1175-81 PMID: 12654868
  54. Herbivore-induced ethylene suppresses a direct defense but not a putative indirect defense against an adapted herbivore.
    Planta. 2000 Jan;210(2):336-42 PMID: 10664141
  55. AtCHIP functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatment.
    Plant J. 2006 May;46(4):649-57 PMID: 16640601
  56. Fresh insights into processes of nonhost resistance.
    Curr Opin Plant Biol. 2003 Aug;6(4):351-7 PMID: 12873530
  57. GMPOZ, a BTB/POZ domain nuclear protein, is a regulator of hormone responsive gene expression in barley aleurone.
    Plant Cell Physiol. 2004 Jul;45(7):945-50 PMID: 15295078
  58. High throughput virus-induced gene silencing implicates heat shock protein 90 in plant disease resistance.
    EMBO J. 2003 Nov 3;22(21):5690-9 PMID: 14592968
  59. Characterization of gene expression of NsERFs, transcription factors of basic PR genes from Nicotiana sylvestris.
    Plant Cell Physiol. 2000 Jun;41(6):817-24 PMID: 10945353
  60. Aux/IAA proteins contain a potent transcriptional repression domain.
    Plant Cell. 2004 Feb;16(2):533-43 PMID: 14742873
  61. N-terminal ubiquitination: more protein substrates join in.
    Trends Cell Biol. 2004 Mar;14(3):103-6 PMID: 15055197
  62. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
    Mol Cell. 2006 Sep 1;23(5):709-21 PMID: 16949367
  63. Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development.
    Plant Cell. 2006 Aug;18(8):1991-2004 PMID: 16844902
  64. slender rice, a constitutive gibberellin response mutant, is caused by a null mutation of the SLR1 gene, an ortholog of the height-regulating gene GAI/RGA/RHT/D8.
    Plant Cell. 2001 May;13(5):999-1010 PMID: 11340177
  65. A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin.
    Biochim Biophys Acta. 2004 Nov 29;1695(1-3):133-70 PMID: 15571813
  66. The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis.
    Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11519-24 PMID: 12169662
  67. HcPro, a multifunctional protein encoded by a plant RNA virus, targets the 20S proteasome and affects its enzymic activities.
    J Gen Virol. 2005 Sep;86(Pt 9):2595-603 PMID: 16099919
  68. Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes.
    Genes Dev. 2004 Sep 1;18(17):2172-81 PMID: 15342494
  69. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
    Mol Cell. 2002 Dec;10(6):1519-26 PMID: 12504026
  70. Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain.
    Cell. 2000 Jul 7;102(1):67-76 PMID: 10929714
  71. Clink, a nanovirus-encoded protein, binds both pRB and SKP1.
    J Virol. 2000 Apr;74(7):2967-72 PMID: 10708410
  72. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.
    Cell. 2001 Jul 27;106(2):145-55 PMID: 11511343
  73. Molecular mechanism of gibberellin signaling in plants.
    Annu Rev Plant Biol. 2004;55:197-223 PMID: 15377219
  74. Significance of inducible defense-related proteins in infected plants.
    Annu Rev Phytopathol. 2006;44:135-62 PMID: 16602946
  75. The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation.
    Plant Cell. 2004 Jun;16(6):1392-405 PMID: 15155881
  76. Brassinosteroids and plant steroid hormone signaling.
    Plant Cell. 2002;14 Suppl:S97-110 PMID: 12045272
  77. The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation.
    Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11416-21 PMID: 10500191
  78. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.
    Science. 1989 Mar 24;243(4898):1576-83 PMID: 2538923
  79. Function and regulation of cullin-RING ubiquitin ligases.
    Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20 PMID: 15688063
  80. The brassinosteroid signal transduction pathway.
    Cell Res. 2006 May;16(5):427-34 PMID: 16699538
  81. Arabidopsis SGT1b is required for SCF(TIR1)-mediated auxin response.
    Plant Cell. 2003 Jun;15(6):1310-9 PMID: 12782725
  82. The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects.
    J Biol Chem. 2002 Dec 20;277(51):50069-80 PMID: 12381738
  83. Ubiquitin: structures, functions, mechanisms.
    Biochim Biophys Acta. 2004 Nov 29;1695(1-3):55-72 PMID: 15571809
  84. The ubiquitin ligase XBAT32 regulates lateral root development in Arabidopsis.
    Plant J. 2004 Dec;40(6):996-1006 PMID: 15584963
  85. The tomato homolog of CORONATINE-INSENSITIVE1 is required for the maternal control of seed maturation, jasmonate-signaled defense responses, and glandular trichome development.
    Plant Cell. 2004 Jan;16(1):126-43 PMID: 14688297
  86. Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.
    Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20 PMID: 16861300
  87. Early elicitor induction in members of a novel multigene family coding for highly related RING-H2 proteins in Arabidopsis thaliana.
    Plant Mol Biol. 1999 Jul;40(4):579-90 PMID: 10480382
  88. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
    Genes Dev. 2004 Dec 15;18(24):3055-65 PMID: 15601820
  89. Auxin: regulation, action, and interaction.
    Ann Bot. 2005 Apr;95(5):707-35 PMID: 15749753
  90. Gibberellin/abscisic acid antagonism in barley aleurone cells: site of action of the protein kinase PKABA1 in relation to gibberellin signaling molecules.
    Plant Cell. 2001 Mar;13(3):667-79 PMID: 11251104
  91. Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.
    Cell. 2004 Nov 12;119(4):517-28 PMID: 15537541
  92. The Arabidopsis F-box protein TIR1 is an auxin receptor.
    Nature. 2005 May 26;435(7041):446-51 PMID: 15917798
  93. The F-box protein TIR1 is an auxin receptor.
    Nature. 2005 May 26;435(7041):441-5 PMID: 15917797
  94. RAR1 positively controls steady state levels of barley MLA resistance proteins and enables sufficient MLA6 accumulation for effective resistance.
    Plant Cell. 2004 Dec;16(12):3480-95 PMID: 15548741
  95. The U-box protein CMPG1 is required for efficient activation of defense mechanisms triggered by multiple resistance genes in tobacco and tomato.
    Plant Cell. 2006 Apr;18(4):1067-83 PMID: 16531490
  96. Molecular interactions between the specialist herbivore Manduca sexta (lepidoptera, sphingidae) and its natural host Nicotiana attenuata: V. microarray analysis and further characterization of large-scale changes in herbivore-induced mRNAs.
    Plant Physiol. 2003 Apr;131(4):1877-93 PMID: 12692347
  97. HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis.
    Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11777-82 PMID: 14504384
  98. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
    Nature. 2006 Oct 5;443(7111):590-3 PMID: 16964240
  99. CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability.
    Nat Cell Biol. 2005 Apr;7(4):387-91 PMID: 15793566
  100. Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2-mediated resistance.
    Cell. 2003 Feb 7;112(3):379-89 PMID: 12581527
  101. Membrane release and destabilization of Arabidopsis RIN4 following cleavage by Pseudomonas syringae AvrRpt2.
    Mol Plant Microbe Interact. 2005 Dec;18(12):1258-68 PMID: 16478045
  102. Arabidopsis SON1 is an F-box protein that regulates a novel induced defense response independent of both salicylic acid and systemic acquired resistance.
    Plant Cell. 2002 Jul;14(7):1469-82 PMID: 12119368
  103. The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit.
    Plant Cell. 2003 Oct;15(10):2370-82 PMID: 14508008
  104. Plant sciences. Recognition at a distance.
    Science. 2005 Apr 22;308(5721):506-8 PMID: 15845841
  105. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana.
    Plant J. 2006 Aug;47(4):591-603 PMID: 16792691
  106. Structure and biochemical function of a prototypical Arabidopsis U-box domain.
    J Biol Chem. 2004 Sep 17;279(38):40053-61 PMID: 15231834
  107. Salt and drought stress signal transduction in plants.
    Annu Rev Plant Biol. 2002;53:247-73 PMID: 12221975
  108. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
    Nature. 2003 Sep 18;425(6955):316-21 PMID: 13679922
  109. Covalent modification of all members of human cullin family proteins by NEDD8.
    Oncogene. 1999 Nov 18;18(48):6829-34 PMID: 10597293
  110. Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast.
    Mol Cell Biol. 2001 May;21(9):3105-17 PMID: 11287615
  111. BIOSYNTHESIS AND ACTION OF JASMONATES IN PLANTS.
    Annu Rev Plant Physiol Plant Mol Biol. 1997 Jun;48:355-381 PMID: 15012267
  112. cDNA-AFLP reveals a striking overlap in race-specific resistance and wound response gene expression profiles.
    Plant Cell. 2000 Jun;12(6):963-77 PMID: 10852940
  113. Molecular players regulating the jasmonate signalling network.
    Curr Opin Plant Biol. 2005 Oct;8(5):532-40 PMID: 16039901
  114. Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases.
    Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18890-5 PMID: 16365295
  115. Molecular and functional characterization of Arabidopsis Cullin 3A.
    Plant J. 2005 Feb;41(3):386-99 PMID: 15659098
  116. Convergence of signaling pathways in the control of differential cell growth in Arabidopsis.
    Dev Cell. 2004 Aug;7(2):193-204 PMID: 15296716
  117. Arabidopsis NPH3: A NPH1 photoreceptor-interacting protein essential for phototropism.
    Science. 1999 Oct 29;286(5441):961-4 PMID: 10542152
  118. Biochemical identification of proteasome-associated endonuclease activity in sunflower.
    Biochim Biophys Acta. 2003 Jan 31;1645(1):30-9 PMID: 12535608
  119. Upregulation of an Arabidopsis RING-H2 gene, XERICO, confers drought tolerance through increased abscisic acid biosynthesis.
    Plant J. 2006 Aug;47(3):343-55 PMID: 16792696
  120. GID2, an F-box subunit of the SCF E3 complex, specifically interacts with phosphorylated SLR1 protein and regulates the gibberellin-dependent degradation of SLR1 in rice.
    Plant J. 2004 Feb;37(4):626-34 PMID: 14756772
  121. The eto1, eto2, and eto3 mutations and cytokinin treatment increase ethylene biosynthesis in Arabidopsis by increasing the stability of ACS protein.
    Plant Cell. 2003 Feb;15(2):545-59 PMID: 12566591
  122. The DELLA motif is essential for gibberellin-induced degradation of RGA.
    Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14162-7 PMID: 11717468
  123. Plants have a sensitive perception system for the most conserved domain of bacterial flagellin.
    Plant J. 1999 May;18(3):265-76 PMID: 10377992
  124. The ASK1 gene regulates development and interacts with the UFO gene to control floral organ identity in Arabidopsis.
    Dev Genet. 1999 Sep;25(3):209-23 PMID: 10528262
  125. A single locus determines sensitivity to bacterial flagellin in Arabidopsis thaliana.
    Plant J. 1999 May;18(3):277-84 PMID: 10377993
  126. AUX/IAA proteins are active repressors, and their stability and activity are modulated by auxin.
    Plant Cell. 2001 Dec;13(12):2809-22 PMID: 11752389
  127. Molecular mechanisms of steroid hormone signaling in plants.
    Annu Rev Cell Dev Biol. 2005;21:177-201 PMID: 16212492
  128. Progress report: ethylene signaling and responses.
    Planta. 2006 Feb;223(3):387-91 PMID: 16322985
  129. Turnover of 1-aminocyclopropane-1-carboxylic Acid synthase protein in wounded tomato fruit tissue.
    Plant Physiol. 1992 Nov;100(3):1126-31 PMID: 16653094
  130. Auxin promotes Arabidopsis root growth by modulating gibberellin response.
    Nature. 2003 Feb 13;421(6924):740-3 PMID: 12610625
  131. Plant pathogens and integrated defence responses to infection.
    Nature. 2001 Jun 14;411(6839):826-33 PMID: 11459065
  132. EL5, a rice N-acetylchitooligosaccharide elicitor-responsive RING-H2 finger protein, is a ubiquitin ligase which functions in vitro in co-operation with an elicitor-responsive ubiquitin-conjugating enzyme, OsUBC5b.
    Plant J. 2002 May;30(4):447-55 PMID: 12028574
  133. Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens.
    Plant Cell. 2002 May;14(5):979-92 PMID: 12034891
  134. An Arabidopsis mutant defective in jasmonate response is allelic to the auxin-signaling mutant axr1.
    Plant Physiol. 2002 Oct;130(2):887-94 PMID: 12376653
  135. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.
    Nature. 2002 Apr 11;416(6881):648-53 PMID: 11923872
  136. The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase.
    Plant Cell. 2003 May;15(5):1120-30 PMID: 12724538
  137. The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis.
    Plant Cell. 2002 Aug;14(8):1919-35 PMID: 12172031
  138. Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.
    Plant Cell. 2002 Sep;14(9):2137-44 PMID: 12215511
  139. Interaction of the tobacco mosaic virus replicase protein with the Aux/IAA protein PAP1/IAA26 is associated with disease development.
    J Virol. 2005 Feb;79(4):2549-58 PMID: 15681455
  140. Characterization of a novel temperature-sensitive allele of the CUL1/AXR6 subunit of SCF ubiquitin-ligases.
    Plant J. 2005 Aug;43(3):371-83 PMID: 16045473
  141. Identification of a new motif for CDPK phosphorylation in vitro that suggests ACC synthase may be a CDPK substrate.
    Arch Biochem Biophys. 2004 Aug 1;428(1):81-91 PMID: 15234272
  142. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.
    Nat Cell Biol. 2004 Oct;6(10):1003-9 PMID: 15448697
  143. The ubiquitin-proteasome pathway and plant development.
    Plant Cell. 2004 Dec;16(12):3181-95 PMID: 15579807
  144. NPR1, all things considered.
    Curr Opin Plant Biol. 2004 Oct;7(5):547-52 PMID: 15337097
  145. A new class of ubiquitin extension proteins secreted by the dorsal pharyngeal gland in plant parasitic cyst nematodes.
    Mol Plant Microbe Interact. 2004 Aug;17(8):846-52 PMID: 15305605
  146. RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed.
    Plant Cell. 2002 May;14(5):1005-15 PMID: 12034893
  147. Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis.
    Plant Cell. 2001 Jul;13(7):1555-66 PMID: 11449051
  148. The Induction of Seed Germination in Arabidopsis thaliana Is Regulated Principally by Phytochrome B and Secondarily by Phytochrome A.
    Plant Physiol. 1994 Feb;104(2):363-371 PMID: 12232088
  149. AFP is a novel negative regulator of ABA signaling that promotes ABI5 protein degradation.
    Genes Dev. 2003 Feb 1;17(3):410-8 PMID: 12569131
  150. RPT2 is a signal transducer involved in phototropic response and stomatal opening by association with phototropin 1 in Arabidopsis thaliana.
    Plant Cell. 2004 Apr;16(4):887-96 PMID: 15031408
  151. Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY.
    Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12771-6 PMID: 15308775
  152. The Arabidopsis HOBBIT gene encodes a CDC27 homolog that links the plant cell cycle to progression of cell differentiation.
    Genes Dev. 2002 Oct 1;16(19):2566-75 PMID: 12368267
  153. Phosphorylation of tomato 1-aminocyclopropane-1-carboxylic acid synthase, LE-ACS2, at the C-terminal region.
    J Biol Chem. 2001 Jul 27;276(30):28051-7 PMID: 11375393
  154. Regulation of transcriptional activation domain function by ubiquitin.
    Science. 2001 Aug 31;293(5535):1651-3 PMID: 11463878
  155. Related to ubiquitin 1 and 2 are redundant and essential and regulate vegetative growth, auxin signaling, and ethylene production in Arabidopsis.
    Plant Cell. 2004 Sep;16(9):2418-32 PMID: 15319484
  156. Functional genomic analysis of the AUXIN RESPONSE FACTOR gene family members in Arabidopsis thaliana: unique and overlapping functions of ARF7 and ARF19.
    Plant Cell. 2005 Feb;17(2):444-63 PMID: 15659631
  157. Members of the Arabidopsis-SKP1-like gene family exhibit a variety of expression patterns and may play diverse roles in Arabidopsis.
    Plant Physiol. 2003 Sep;133(1):203-17 PMID: 12970487
  158. Activation of a stress-responsive mitogen-activated protein kinase cascade induces the biosynthesis of ethylene in plants.
    Plant Cell. 2003 Nov;15(11):2707-18 PMID: 14555690
  159. Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis.
    Plant J. 2003 Jun;34(6):753-67 PMID: 12795696
  160. Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis.
    Plant Physiol. 2005 Jan;137(1):13-30 PMID: 15644464
  161. ORE9, an F-box protein that regulates leaf senescence in Arabidopsis.
    Plant Cell. 2001 Aug;13(8):1779-90 PMID: 11487692
  162. The ubiquitin 26S proteasome proteolytic pathway.
    Annu Rev Plant Biol. 2004;55:555-90 PMID: 15377232
  163. Differential regulation of TGA transcription factors by post-transcriptional control.
    Plant J. 2002 Dec;32(5):641-53 PMID: 12472682
  164. The Tobacco mosaic virus replicase protein disrupts the localization and function of interacting Aux/IAA proteins.
    Mol Plant Microbe Interact. 2006 Aug;19(8):864-73 PMID: 16903352
  165. The parasitome of the phytonematode Heterodera glycines.
    Mol Plant Microbe Interact. 2003 Aug;16(8):720-6 PMID: 12906116
  166. The E3 ubiquitin ligase activity of arabidopsis PLANT U-BOX17 and its functional tobacco homolog ACRE276 are required for cell death and defense.
    Plant Cell. 2006 Apr;18(4):1084-98 PMID: 16531496
  167. Basal defenses induced in pepper by lipopolysaccharides are suppressed by Xanthomonas campestris pv. vesicatoria.
    Mol Plant Microbe Interact. 2004 Jul;17(7):805-15 PMID: 15242175
  168. Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1.
    Genes Dev. 1998 Dec 1;12(23):3703-14 PMID: 9851977
  169. CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
    Mol Cell Biol. 2006 Feb;26(4):1235-44 PMID: 16449638
  170. Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis.
    Genes Dev. 2004 Feb 15;18(4):448-60 PMID: 14977918
  171. Perturbation of the ubiquitin system causes leaf curling, vascular tissue alterations and necrotic lesions in a higher plant.
    EMBO J. 1990 Dec;9(13):4543-9 PMID: 2176155
  172. A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase.
    Science. 2006 Jan 13;311(5758):222-6 PMID: 16373536
  173. BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation.
    Cell. 2002 Apr 19;109(2):181-91 PMID: 12007405
  174. Nar-1 and Nar-2, Two Loci Required for Mla12-Specified Race-Specific Resistance to Powdery Mildew in Barley.
    Plant Cell. 1994 Jul;6(7):983-994 PMID: 12244263
  175. Innate immunity in plants and animals: striking similarities and obvious differences.
    Immunol Rev. 2004 Apr;198:249-66 PMID: 15199967
  176. Arabidopsis anaphase-promoting complexes: multiple activators and wide range of substrates might keep APC perpetually busy.
    Cell Cycle. 2005 Aug;4(8):1084-92 PMID: 15970679
  177. The HECT ubiquitin-protein ligase (UPL) family in Arabidopsis: UPL3 has a specific role in trichome development.
    Plant J. 2003 Sep;35(6):729-42 PMID: 12969426
  178. SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals.
    Nature. 2002 Sep 12;419(6903):167-70 PMID: 12226665
  179. Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana.
    Genes Dev. 1999 Jul 1;13(13):1678-91 PMID: 10398681
  180. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.
    Science. 2002 Oct 18;298(5593):608-11 PMID: 12183637
  181. Regulation of ethylene gas biosynthesis by the Arabidopsis ETO1 protein.
    Nature. 2004 Apr 29;428(6986):945-50 PMID: 15118728
  182. A large complement of the predicted Arabidopsis ARM repeat proteins are members of the U-box E3 ubiquitin ligase family.
    Plant Physiol. 2004 Jan;134(1):59-66 PMID: 14657406
  183. The ethylene signaling pathway.
    Science. 2004 Nov 26;306(5701):1513-5 PMID: 15567852
  184. The BTB/POZ domain of the regulatory proteins Bric à brac 1 (BAB1) and Bric à brac 2 (BAB2) interacts with the novel Drosophila TAF(II) factor BIP2/dTAF(II)155.
    Dev Biol. 2001 Sep 15;237(2):368-80 PMID: 11543621
  185. Two Pseudomonas syringae type III effectors inhibit RIN4-regulated basal defense in Arabidopsis.
    Cell. 2005 Jun 3;121(5):749-59 PMID: 15935761
  186. The role of GA-mediated signalling in the control of seed germination.
    Curr Opin Plant Biol. 2002 Oct;5(5):376-81 PMID: 12183174
  187. Ethylene signal transduction. Moving beyond Arabidopsis.
    Plant Physiol. 2004 Jun;135(2):660-7 PMID: 15208412
  188. Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.
    Plant Cell. 2004 Jul;16(7):1870-82 PMID: 15208391
  189. Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.
    Science. 2005 Jul 1;309(5731):127-30 PMID: 15994556
  190. Tobacco mosaic virus induced alterations in the gene expression profile of Arabidopsis thaliana.
    Mol Plant Microbe Interact. 2003 Aug;16(8):681-8 PMID: 12906112
  191. Two immediate-early pathogen-responsive members of the AtCMPG gene family in Arabidopsis thaliana and the W-box-containing elicitor-response element of AtCMPG1.
    Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9049-54 PMID: 12084942
  192. Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.
    EMBO J. 2005 Nov 16;24(22):3940-51 PMID: 16252005
  193. The ANK repeat: a ubiquitous motif involved in macromolecular recognition.
    Trends Cell Biol. 1992 May;2(5):127-9 PMID: 14731966
  194. H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response.
    Cell. 1994 Nov 18;79(4):583-93 PMID: 7954825
  195. Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis.
    Plant Physiol. 2005 Jun;138(2):1046-57 PMID: 15908606
  196. Effect of ethylene pathway mutations upon expression of the ethylene receptor ETR1 from Arabidopsis.
    Plant Physiol. 2002 Dec;130(4):1983-91 PMID: 12481081
  197. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans.
    Curr Biol. 2003 May 27;13(11):911-21 PMID: 12781129
  198. Structure of the Arabidopsis RPM1 gene enabling dual specificity disease resistance.
    Science. 1995 Aug 11;269(5225):843-6 PMID: 7638602
  199. The Arabidopsis cullin AtCUL1 is modified by the ubiquitin-related protein RUB1.
    Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15342-7 PMID: 10611386
  200. Post-translational regulation in plants employing a diverse set of polypeptide tags.
    Biochem Soc Trans. 2005 Apr;33(Pt 2):393-9 PMID: 15787614
  201. The transcriptional innate immune response to flg22. Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis.
    Plant Physiol. 2004 Jun;135(2):1113-28 PMID: 15181213
  202. Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis.
    Plant Cell. 2004 Dec;16(12):3386-99 PMID: 15539472
  203. Auxin receptors: a new role for F-box proteins.
    Curr Opin Cell Biol. 2006 Apr;18(2):152-6 PMID: 16488128
  204. Plant CULLIN-based E3s: phytohormones come first.
    FEBS Lett. 2005 Jun 13;579(15):3239-45 PMID: 15943967
  205. A role for the ubiquitin-26S-proteasome pathway in gibberellin signaling.
    Trends Plant Sci. 2003 Oct;8(10):492-7 PMID: 14557046
  206. ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate pathways in plant defense.
    Plant Cell. 2003 Jan;15(1):165-78 PMID: 12509529
  207. An auxin-inducible F-box protein CEGENDUO negatively regulates auxin-mediated lateral root formation in Arabidopsis.
    Plant Mol Biol. 2006 Mar;60(4):599-615 PMID: 16525894
  208. Gibberellin-regulated expression of a myb gene in barley aleurone cells: evidence for Myb transactivation of a high-pI alpha-amylase gene promoter.
    Plant Cell. 1995 Nov;7(11):1879-91 PMID: 8535141
  209. MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway.
    Proc Natl Acad Sci U S A. 1998 May 12;95(10):5678-83 PMID: 9576943
  210. Auxin-induced SCFTIR1-Aux/IAA interaction involves stable modification of the SCFTIR1 complex.
    Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12381-6 PMID: 15295098
  211. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
    Nature. 2005 Jun 30;435(7046):1257-61 PMID: 15988528
  212. The AUXIN RESPONSE FACTOR 2 gene of Arabidopsis links auxin signalling, cell division, and the size of seeds and other organs.
    Development. 2006 Jan;133(2):251-61 PMID: 16339187
  213. Arabidopsis NAC1 transduces auxin signal downstream of TIR1 to promote lateral root development.
    Genes Dev. 2000 Dec 1;14(23):3024-36 PMID: 11114891
  214. Ethylene: a gaseous signal molecule in plants.
    Annu Rev Cell Dev Biol. 2000;16:1-18 PMID: 11031228
  215. FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis.
    Science. 2005 Jul 8;309(5732):293-7 PMID: 16002617
  216. EIN3-dependent regulation of plant ethylene hormone signaling by two arabidopsis F box proteins: EBF1 and EBF2.
    Cell. 2003 Dec 12;115(6):679-89 PMID: 14675533
  217. The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p.
    Genes Dev. 1998 Jan 15;12(2):198-207 PMID: 9436980
  218. Gibberellins signal nuclear import of PHOR1, a photoperiod-responsive protein with homology to Drosophila armadillo.
    Cell. 2001 Aug 10;106(3):343-54 PMID: 11509183
  219. Regulated proteolysis and plant development.
    Plant Cell Rep. 2004 Nov;23(6):353-64 PMID: 15365760
  220. Recognition of the polyubiquitin proteolytic signal.
    EMBO J. 2000 Jan 4;19(1):94-102 PMID: 10619848
  221. The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses.
    Plant Cell. 2003 May;15(5):1083-94 PMID: 12724535
  222. The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division.
    Plant Cell. 2005 Sep;17(9):2527-41 PMID: 16055635
  223. Degradation of tobacco mosaic virus movement protein by the 26S proteasome.
    J Virol. 2000 Apr;74(7):3330-7 PMID: 10708450
  224. COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis.
    Plant J. 2002 Nov;32(4):457-66 PMID: 12445118
  225. Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
    Cell. 2000 Aug 18;102(4):533-9 PMID: 10966114
  226. Ubiquitin recognition by the human TSG101 protein.
    Mol Cell. 2004 Mar 26;13(6):783-9 PMID: 15053872
  227. Applications of network BLAST server.
    Methods Enzymol. 1996;266:131-41 PMID: 8743682
  228. In vitro assembly and recognition of Lys-63 polyubiquitin chains.
    J Biol Chem. 2001 Jul 27;276(30):27936-43 PMID: 11369780
  229. The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis.
    Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10185-90 PMID: 12114546
  230. RAC GTPases in tobacco and Arabidopsis mediate auxin-induced formation of proteolytically active nuclear protein bodies that contain AUX/IAA proteins.
    Plant Cell. 2005 Aug;17(8):2369-83 PMID: 15994909
  231. Integration of plant responses to environmentally activated phytohormonal signals.
    Science. 2006 Jan 6;311(5757):91-4 PMID: 16400150
  232. Ethylene regulates arabidopsis development via the modulation of DELLA protein growth repressor function.
    Plant Cell. 2003 Dec;15(12):2816-25 PMID: 14615596
  233. SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase.
    EMBO J. 2001 Jun 1;20(11):2742-56 PMID: 11387208
  234. ARIA, an Arabidopsis arm repeat protein interacting with a transcriptional regulator of abscisic acid-responsive gene expression, is a novel abscisic acid signaling component.
    Plant Physiol. 2004 Nov;136(3):3639-48 PMID: 15516505
  235. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.
    Mol Cell. 1999 Jul;4(1):21-33 PMID: 10445024
  236. Classification and expression analysis of Arabidopsis F-box-containing protein genes.
    Plant Cell Physiol. 2002 Oct;43(10):1073-85 PMID: 12407186
  237. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.
    Cell. 1999 Nov 12;99(4):355-66 PMID: 10571178
  238. The rub family of ubiquitin-like proteins. Crystal structure of Arabidopsis rub1 and expression of multiple rubs in Arabidopsis.
    J Biol Chem. 1998 Dec 25;273(52):34976-82 PMID: 9857029
  239. Ubiquitination-mediated protein degradation and modification: an emerging theme in plant-microbe interactions.
    Cell Res. 2006 May;16(5):413-26 PMID: 16699537
  240. Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing.
    Plant J. 2004 Oct;40(2):291-301 PMID: 15447654
  241. HOOKLESS1, an ethylene response gene, is required for differential cell elongation in the Arabidopsis hypocotyl.
    Cell. 1996 Apr 19;85(2):183-94 PMID: 8612271
  242. Functional analysis of Avr9/Cf-9 rapidly elicited genes identifies a protein kinase, ACIK1, that is essential for full Cf-9-dependent disease resistance in tomato.
    Plant Cell. 2005 Jan;17(1):295-310 PMID: 15598806
  243. Gibberellin signaling in barley aleurone cells. Control of SLN1 and GAMYB expression.
    Plant Physiol. 2002 May;129(1):191-200 PMID: 12011350
  244. The ATL gene family from Arabidopsis thaliana and Oryza sativa comprises a large number of putative ubiquitin ligases of the RING-H2 type.
    J Mol Evol. 2006 Apr;62(4):434-45 PMID: 16557337
  245. JASMONATE-INSENSITIVE1 encodes a MYC transcription factor essential to discriminate between different jasmonate-regulated defense responses in Arabidopsis.
    Plant Cell. 2004 Jul;16(7):1938-50 PMID: 15208388
  246. Non-traditional functions of ubiquitin and ubiquitin-binding proteins.
    J Biol Chem. 2003 Sep 19;278(38):35857-60 PMID: 12860974
  247. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases.
    Mol Cell. 1998 Nov;2(5):571-80 PMID: 9844630
  248. Wnt signaling: complexity at the surface.
    J Cell Sci. 2006 Feb 1;119(Pt 3):395-402 PMID: 16443747
  249. The ARF family of transcription factors and their role in plant hormone-responsive transcription.
    Cell Mol Life Sci. 1998 Jul;54(7):619-27 PMID: 9711229
  250. Targeted destabilization of HY5 during light-regulated development of Arabidopsis.
    Nature. 2000 May 25;405(6785):462-6 PMID: 10839542
  251. AtCAND1, a HEAT-repeat protein that participates in auxin signaling in Arabidopsis.
    Plant Physiol. 2004 Jun;135(2):1020-6 PMID: 15181201
  252. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.
    Science. 2004 Feb 27;303(5662):1371-4 PMID: 14739464
  253. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins.
    Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11324-9 PMID: 9736735
  254. Downstream nuclear events in brassinosteroid signalling.
    Nature. 2006 May 4;441(7089):96-100 PMID: 16672972
  255. ABA depolarizes guard cells in intact plants, through a transient activation of R- and S-type anion channels.
    Plant J. 2004 Feb;37(4):578-88 PMID: 14756768
  256. The Arabidopsis mutant sleepy1gar2-1 protein promotes plant growth by increasing the affinity of the SCFSLY1 E3 ubiquitin ligase for DELLA protein substrates.
    Plant Cell. 2004 Jun;16(6):1406-18 PMID: 15161962
  257. The BTB protein MEL-26 promotes cytokinesis in C. elegans by a CUL-3-independent mechanism.
    Curr Biol. 2005 Sep 20;15(18):1605-15 PMID: 16169482
  258. Molecular analyses of the Arabidopsis TUBBY-like protein gene family.
    Plant Physiol. 2004 Apr;134(4):1586-97 PMID: 15064372
  259. PIN proteins perform a rate-limiting function in cellular auxin efflux.
    Science. 2006 May 12;312(5775):914-8 PMID: 16601150
  260. A highly specific pathogen-responsive promoter element from the immediate-early activated CMPG1 gene in Petroselinum crispum.
    Plant J. 2001 Apr;26(2):217-27 PMID: 11389762
  261. HISTONE DEACETYLASE19 is involved in jasmonic acid and ethylene signaling of pathogen response in Arabidopsis.
    Plant Cell. 2005 Apr;17(4):1196-204 PMID: 15749761
  262. The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem.
    Plant J. 1999 Nov;20(4):433-45 PMID: 10607296
  263. Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo.
    Plant Cell. 2005 Apr;17(4):1180-95 PMID: 15772280
  264. Role of SGT1 in resistance protein accumulation in plant immunity.
    EMBO J. 2006 May 3;25(9):2007-16 PMID: 16619029
  265. A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response.
    Plant J. 2005 Oct;44(2):258-70 PMID: 16212605
  266. Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to Tobacco mosaic virus.
    Plant Cell. 2002 Jul;14(7):1483-96 PMID: 12119369
  267. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.
    Mol Cell Biol. 2001 Oct;21(20):6782-95 PMID: 11564863
  268. Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase.
    J Biol Chem. 2004 Feb 6;279(6):3916-24 PMID: 14638690
  269. PEST sequences and regulation by proteolysis.
    Trends Biochem Sci. 1996 Jul;21(7):267-71 PMID: 8755249
  270. F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function.
    Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1994-9 PMID: 16446454
  271. A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants.
    Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8577-82 PMID: 12817082
  272. The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance.
    Science. 2002 Mar 15;295(5562):2073-6 PMID: 11847307
  273. NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
    Mol Cell. 2002 Dec;10(6):1511-8 PMID: 12504025
  274. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding.
    Cell. 2001 Oct 5;107(1):55-65 PMID: 11595185
  275. The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1.
    Plant Cell. 2003 Sep;15(9):2181-91 PMID: 12953119
  276. GIBBERELLIN INSENSITIVE DWARF1 encodes a soluble receptor for gibberellin.
    Nature. 2005 Sep 29;437(7059):693-8 PMID: 16193045
  277. Aux/IAA proteins repress expression of reporter genes containing natural and highly active synthetic auxin response elements.
    Plant Cell. 1997 Nov;9(11):1963-71 PMID: 9401121
  278. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
    Nature. 2003 Sep 18;425(6955):311-6 PMID: 13679921
  279. Arabidopsis SGT1b is required for defense signaling conferred by several downy mildew resistance genes.
    Plant Cell. 2002 May;14(5):993-1003 PMID: 12034892
  280. The ethylene signaling pathway: new insights.
    Curr Opin Plant Biol. 2004 Feb;7(1):40-9 PMID: 14732440
  281. Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1.
    Cell Cycle. 2005 Jan;4(1):27-9 PMID: 15655366
  282. The pleiotropic role of the 26S proteasome subunit RPN10 in Arabidopsis growth and development supports a substrate-specific function in abscisic acid signaling.
    Plant Cell. 2003 Apr;15(4):965-80 PMID: 12671091
  283. Light activates the degradation of PIL5 protein to promote seed germination through gibberellin in Arabidopsis.
    Plant J. 2006 Jul;47(1):124-39 PMID: 16740147
  284. Tall tales from sly dwarves: novel functions of gibberellins in plant development.
    Trends Plant Sci. 2005 Mar;10(3):123-9 PMID: 15749470
  285. The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation.
    Proc Natl Acad Sci U S A. 2005 May 3;102(18):6496-501 PMID: 15845764
  286. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
    Cell. 2003 May 2;113(3):357-67 PMID: 12732143
  287. Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH protein family.
    Plant Physiol. 2005 Jan;137(1):83-93 PMID: 15618422
  288. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.
    Mol Cell Biol. 2003 Oct;23(19):6790-7 PMID: 12972599
  289. BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
    Hum Mol Genet. 2004 Apr 15;13(8):807-17 PMID: 14976165
  290. Infectivity of nanovirus DNAs: induction of disease by cloned genome components of Faba bean necrotic yellows virus.
    J Gen Virol. 2006 Jun;87(Pt 6):1735-43 PMID: 16690940
  291. Antagonistic control of disease resistance protein stability in the plant immune system.
    Science. 2005 Aug 5;309(5736):929-32 PMID: 15976272
  292. Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis.
    Genetics. 1999 May;152(1):401-12 PMID: 10224270
  293. Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis.
    J Biol Chem. 2005 May 13;280(19):18810-21 PMID: 15749712
  294. cop1: a regulatory locus involved in light-controlled development and gene expression in Arabidopsis.
    Genes Dev. 1991 Jul;5(7):1172-82 PMID: 2065972
  295. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.
    Science. 2001 May 18;292(5520):1382-5 PMID: 11337588
  296. Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis.
    Plant Physiol. 2005 Dec;139(4):1597-611 PMID: 16339806
  297. A proteomics approach to understanding protein ubiquitination.
    Nat Biotechnol. 2003 Aug;21(8):921-6 PMID: 12872131
  298. Plant development is regulated by a family of auxin receptor F box proteins.
    Dev Cell. 2005 Jul;9(1):109-19 PMID: 15992545
  299. Auxin signaling.
    J Cell Sci. 2006 Apr 1;119(Pt 7):1199-202 PMID: 16554435
  300. Interplay of signaling pathways in plant disease resistance.
    Trends Genet. 2000 Oct;16(10):449-55 PMID: 11050331
  301. Structural insights into the U-box, a domain associated with multi-ubiquitination.
    Nat Struct Biol. 2003 Apr;10(4):250-5 PMID: 12627222
  302. Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization.
    J Biol Chem. 2000 Oct 13;275(41):32317-24 PMID: 10921923
  303. A postgermination developmental arrest checkpoint is mediated by abscisic acid and requires the ABI5 transcription factor in Arabidopsis.
    Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4782-7 PMID: 11287670
  304. The role of ethylene in host-pathogen interactions.
    Annu Rev Phytopathol. 2006;44:393-416 PMID: 16602950
  305. Molecular genetic evidence for the role of SGT1 in the intramolecular complementation of Bs2 protein activity in Nicotiana benthamiana.
    Plant Cell. 2005 Apr;17(4):1268-78 PMID: 15749757
  306. Ubiquitinated conjugates are found in preparations of several plant viruses.
    Virology. 1990 Jul;177(1):352-6 PMID: 2162109
  307. Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein.
    EMBO J. 2003 Nov 3;22(21):5679-89 PMID: 14592967
  308. Characterization of an Arabidopsis Mutant That Is Nonresponsive to Inducers of Systemic Acquired Resistance.
    Plant Cell. 1994 Nov;6(11):1583-1592 PMID: 12244227
  309. Rapid degradation of auxin/indoleacetic acid proteins requires conserved amino acids of domain II and is proteasome dependent.
    Plant Cell. 2001 Oct;13(10):2349-60 PMID: 11595806
  310. Red light-induced formation of ubiquitin-phytochrome conjugates: Identification of possible intermediates of phytochrome degradation.
    Proc Natl Acad Sci U S A. 1987 Jan;84(2):359-63 PMID: 16593800
  311. The N-end rule and regulation of apoptosis.
    Nat Cell Biol. 2003 May;5(5):373-6 PMID: 12724766
  312. Plant Rac-like GTPases are activated by auxin and mediate auxin-responsive gene expression.
    Plant Cell. 2002 Nov;14(11):2745-60 PMID: 12417698
  313. Arabidopsis RGL1 encodes a negative regulator of gibberellin responses.
    Plant Cell. 2002 Jan;14(1):87-100 PMID: 11826301
  314. Regulatory role of SGT1 in early R gene-mediated plant defenses.
    Science. 2002 Mar 15;295(5562):2077-80 PMID: 11847308
  315. Null mutation of AtCUL1 causes arrest in early embryogenesis in Arabidopsis.
    Mol Biol Cell. 2002 Jun;13(6):1916-28 PMID: 12058059
  316. Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms.
    Genes Dev. 2003 May 1;17(9):1130-40 PMID: 12695334
  317. Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5.
    J Biol Chem. 1996 Feb 2;271(5):2823-31 PMID: 8576261
  318. Regulated proteolysis in light signaling.
    Curr Opin Plant Biol. 2005 Oct;8(5):469-76 PMID: 16039154
  319. Suppression of Bean Defense Responses by Pseudomonas syringae.
    Plant Cell. 1993 Jan;5(1):57-63 PMID: 12271016
  320. Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis.
    Dev Cell. 2002 Apr;2(4):505-13 PMID: 11970900
  321. Update on gibberellin signaling. A tale of the tall and the short.
    Plant Physiol. 2004 Jun;135(2):668-76 PMID: 15208413
  322. The HVE/CAND1 gene is required for the early patterning of leaf venation in Arabidopsis.
    Development. 2006 Oct;133(19):3755-66 PMID: 16943276
  323. Phytochrome regulation and differential expression of gibberellin 3beta-hydroxylase genes in germinating Arabidopsis seeds.
    Plant Cell. 1998 Dec;10(12):2115-26 PMID: 9836749
  324. Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis.
    EMBO J. 2003 Jul 1;22(13):3314-25 PMID: 12839993
  325. Post-transcriptional control of the Arabidopsis auxin efflux carrier EIR1 requires AXR1.
    Curr Biol. 2000 Dec 14-28;10(24):1595-8 PMID: 11137012
  326. EID1, an F-box protein involved in phytochrome A-specific light signaling.
    Genes Dev. 2001 Apr 15;15(8):939-44 PMID: 11316788
  327. Relay and control of abscisic acid signaling.
    Curr Opin Plant Biol. 2003 Oct;6(5):470-9 PMID: 12972048
  328. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology.
    Nat Cell Biol. 2006 Jul;8(7):700-10 PMID: 16799550
  329. Plant disease-resistance proteins and the gene-for-gene concept.
    Trends Biochem Sci. 1998 Dec;23(12):454-6 PMID: 9868361
  330. A plant miRNA contributes to antibacterial resistance by repressing auxin signaling.
    Science. 2006 Apr 21;312(5772):436-9 PMID: 16627744
  331. The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response.
    Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15849-54 PMID: 9861059
  332. Spotted leaf11, a negative regulator of plant cell death and defense, encodes a U-box/armadillo repeat protein endowed with E3 ubiquitin ligase activity.
    Plant Cell. 2004 Oct;16(10):2795-808 PMID: 15377756
  333. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family.
    Cell. 1996 Apr 19;85(2):281-90 PMID: 8612280
  334. Expression and interaction analysis of Arabidopsis Skp1-related genes.
    Plant Cell Physiol. 2004 Jan;45(1):83-91 PMID: 14749489
  335. The ASK1 and ASK2 genes are essential for Arabidopsis early development.
    Plant Cell. 2004 Jan;16(1):5-20 PMID: 14688296
  336. Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium.
    Nature. 2004 Sep 2;431(7004):87-92 PMID: 15343337
  337. Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase.
    Plant Cell. 2004 Jul;16(7):1883-97 PMID: 15208392
  338. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.
    Mol Cell Biol. 1998 Jan;18(1):576-89 PMID: 9418904
  339. Recessive and dominant mutations in the ethylene biosynthetic gene ACS5 of Arabidopsis confer cytokinin insensitivity and ethylene overproduction, respectively.
    Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4766-71 PMID: 9539813
  340. Roles and activities of Aux/IAA proteins in Arabidopsis.
    Trends Plant Sci. 2001 Sep;6(9):420-5 PMID: 11544131
  341. The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.
    Curr Biol. 2002 Apr 16;12(8):667-72 PMID: 11967155
  342. Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity.
    Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2851-6 PMID: 16477026
  343. Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation.
    Cell. 1997 Nov 14;91(4):491-500 PMID: 9390558
Article Info
Journal
Annals of botany
Abbr.
Ann Bot
ISSN
0305-7364
DOI
10.1093/aob/mcl255
Email
[email protected]
Published
2007-05-00
Epub
2007-00-12
Pages
787-822
Language
English
Region
England
NLM ID
0372347
PMCID
PMC2802907
Subset
IM
Grants
NIGMS NIH HHS · T32 GM007377 · United States
NIGMS NIH HHS · GM-0007377-27 · United States
External Links
PubMed source DOI: 10.1093/aob/mcl255 PMC Full Text View journal details
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