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PMID: 8336674 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Biology of DNA restriction.

Microbiological reviews ·Vol. 57 ·No. 2 ·1993-06-00 ·Pages 434-50

Bickle TA, Krüger DH

Abstract

Our understanding of the evolution of DNA restriction and modification systems, the control of the expression of the structural genes for the enzymes, and the importance of DNA restriction in the cellular economy has advanced by leaps and bounds in recent years. This review documents these advances for the three major classes of classical restriction and modification systems, describes the discovery of a new class of restriction systems that specifically cut DNA carrying the modification signature of foreign cells, and deals with the mechanisms developed by phages to avoid the restriction systems of their hosts.

MeSH Terms
Bacteria/enzymology Bacteriophages/genetics Base Sequence Binding Sites DNA Restriction-Modification Enzymes/chemistry,genetics,metabolism DNA, Viral/chemistry,metabolism Gene Expression Regulation, Enzymologic Molecular Sequence Data Structure-Activity Relationship
Chemicals
DNA Restriction-Modification Enzymes DNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bickle T A
Department of Microbiology, Biozentrum, Basel University, Switzerland.
Krüger D H
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Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.57.2.434-450.1993
Published
1993-06-00
Pages
434-50
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC372918
Subset
IM
External Links
PubMed source DOI: 10.1128/mr.57.2.434-450.1993 PMC Full Text
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